NGHIÊN CỨU TỶ LỆ, ĐẶC ĐIỂM ĐA HÌNH GEN MTHFR C677T VÀ NỒNG ĐỘ CYSTATIN C HUYẾT THANH Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TUÝP 2 CÓ BỆNH THẬN MẠN TẠI BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ

Abstract

Background: The Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism was associated with diabetic nephropathy, besides serum cystatin C was currently considered a biomarker to help detect early decline in glomerular filtration rate. Objectives: To determine the rate, characteristics of the MTHFR C677T gene polymorphism and serum cystatin C concentration in type 2 diabetes patients with chronic kidney disease at Can Tho University of Medicine and Pharmacy Hospital in 2023-2024. Materials and method: A cross-sectional descriptive study on a total of 60 patients with diabetic nephropathy hospitalized at Can Tho University of Medicine and Pharmacy Hospital. Results: The rate of CC genotype accounted for 63.3%, followed by CT accounted for 36.7%, TT genotype was not been recorded. The rate of carrying the T allele was 18.3%. The average level of serum cystatin C in patients with kidney damage, creatinine-based estimated GFR <60 mL/min/1.73m² was 1.73 ± 0.89 mg/L higher than the kidney damage group with creatinine-based estimated GFR ≥60 mL/min/1.73 m² (0.93 ± 0.13; 1 ± 0.17 mg/L), with p < 0.05. The proportion of patients assessed for kidney failure with serum cystatin C–based estimated GFR was greater than that with serum creatinine-based estimated GFR. Conclusion: The rate of MTHFR 677CT genotype was 36.7%, TT genotype has not been recorded. The rate of carrying the T allele was 18.3%. Serum cystatin C helped to detect patients with kidney failure that had not been detected based on serum creatinine, so it should be used to evaluate kidney function.