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THE CHARACTERISTICS OF THE MTHFR C677T GENE POLYMORPHISM, BLOOD HOMOCYSTEINE LEVELS AND THEIR RELATIONSHIP WITH SOME CARDIOVASCULAR RISK FACTORS IN TYPE 2 DIABETES PATIENTS
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Abstract
Background: The MTHFR C677T polymorphism leads to a decrease in MTHFR concentration, thereby increasing the blood levels of Homocysteine (Hcy). Elevated Hcy levels predict the risk of mortality or cardiovascular events in type 2 diabetes mellitus (T2DM) patients. Significantly higher levels of Hcy were observed in individuals carrying the MTHFR C677T gene polymorphism. Objectives: To investigate the characteristics of the MTHFR C677T polymorphism, Homocysteine levels, and their correlation with some cardiovascular risk factors in type 2 diabetes mellitus patients. Materials and method: A cross-sectional descriptive study conducted on 89 type
2 diabetes mellitus patients at Can Tho University of Medicine and Pharmacy Hospital. Results:
The frequency of the 677CC, 677CT, and 677TT genotypes in the type 2 diabetes mellitus patients was 66.3%, 28.1%, and 5.6%, respectively. The frequency of the T allele was 19.7%. The average blood Hcy concentration in type 2 diabetes mellitus patients with the TT genotype were significantly higher at 21.1 ± 30.2 µmol/L compared to those with the CC genotype at 8.12 ± 4.56 µmol/L and CT genotype at 8.91 ± 2.72 µmol/L (p < 0.05). The duration of type 2 diabetes mellitus and the TT genotype were independent factors significantly influencing blood Hcy levels. Conclusion: The CC genotype of the MTHFR C677T polymorphism has the highest prevalence, followed by CT and TT genotypes. The frequency of the C allele was higher than that of the T allele. Blood Hcy levels were significantly higher in type 2 diabetes mellitus patients with the TT genotype compared to those with CC and CT genotypes. Patients with type 2 diabetes mellitus with a longer duration of the disease and the TT genotype have an increased risk of elevated blood Hcy levels.
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Keywords
MTHFR C677T, Homocysteine, diabetes type 2
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