NGHIÊN CỨU GIÁ TRỊ CỦA SIÊU ÂM ĐÁNH DẤU MÔ CƠ TIM TRONG DỰ BÁO RỐI LOẠN CHỨC NĂNG TÂM THU THẤT TRÁI DO ANTHRACYCLINES TRÊN BỆNH NHÂN UNG THƯ

Abstract

Background: Cardiac dysfunction is recognized as a side effect of chemotherapy. Early detection of heart dysfunction helps doctors minimize heart complications for patients.  Objectives:  Research on the value of speckle tracking echocardiography in predicting left ventricular systolic dysfunction caused by anthracyclines in cancer patients. Materials and methods: Patients diagnosed with cancer using chemotherapy regimens containing anthracyclines had three echocardiograms to assess the value of left ventricular global longitudinal strain and find out the relationship with toxicity chemotherapy drugs on the heart. Results: 60 patients were involved in the research, in which the age median was 54.03 ± 10.26, and 86,7% were female. Results for the average LVGLS at time T0: -18.46 ± 2.79, decreased at time T1: -15.90 ± 3.11, increased at time T2: -17.13 ± 4.51.  LVEF median was 60.03 ± 6.42 at time T0, 58.26 ± 7.30 at time T1, 57.48 ± 8.13 at time T2. There was a relationship between Left Ventricular Global Longitudinal Strain  (LVGLS) and chemotherapy - induced cardiotoxicity, and LVGLS was an early predictor of cardiotoxicity with a relative reduction cut off 17.78%, sensitivity 66.7%, specificity 77.1%, the area under the curve AUC = 0.72 (95% CI 0.555 – 0.886), p = 0.019. At time T2, the area under the curve AUC = 0.693 (95% CI 0.540 – 0.845), the cut-off point for a relative reduction in LVGLS 4.71%, sensitivity 83.3%, specificity 58,3%, p = 0.04. There was a correlation between the relative decrease in EF T2 and the relative decrease in LVGLS T2 with r=0.409, p=0.013. Conclusion: LVGLS decreased during anthracycline chemotherapy was a predictive factor for the occurrence of chemotherapyinduced cardiotoxicity in those patients.