KHẢO SÁT ĐẶC ĐIỂM RỐI LOẠN ĐÔNG CẦM MÁU TRÊN BỆNH NHÂN XƠ GAN TẠI BỆNH VIỆN ĐA KHOA ĐỒNG THÁP

Abstract

Background: All three phases of hemostasis—primary hemostasis, plasma coagulation, and fibrinolysis—experience complicated alterations due to cirrhosis. Objectives: To determine the correlation between the degree of cirrhosis and upper gastrointestinal bleeding from ruptured varices of the esophageal and the features of hemostatic diseases. Materials and methods: The case series study describes 100 cirrhotic from April 2023 to January 2024. Results: There were 68% of patients with decreased platelet count. About 80% had abnormal PT, INR, and PT%, 71% had prolonged APTT and 57% had decreased fibrinogen. Patients with more severe cirrhosis have more prolonged APTT, PT, and INR. In cases of severe decrease in fibrinogen, most patients were Child C (85.7%). All patients with gastrointestinal bleeding due to ruptured esophageal varices had abnormal PT, PT%, and INR. Patients with a more severe decrease in fibrinogen were correlated with a higher rate of upper gastrointestinal bleeding (p < 0.05). Conclusions: Abnormal coagulation disorders were related to the degree of cirrhosis and complications of upper gastrointestinal bleeding due to ruptured esophageal varices.