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Date Published: 27/05/2024
Online Published: 27/05/2024
Abstract Views: 107
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DOI: https://doi.org/10.58490/ctump.2024i74.2423
Issue
No. 74 (2024)
Section
Article
How to Cite
Thai, N. D., & Nguyen, N. R. (2024). EFFICACY OF LACTOSE-FREE MILK IN TREATING ROTAVIRUS-INDUCED ACUTE GASTROENTERITIS IN INFANTS. Cantho Journal of Medicine and Pharmacy, 74, 73-79. https://doi.org/10.58490/ctump.2024i74.2423

EFFICACY OF LACTOSE-FREE MILK IN TREATING ROTAVIRUS-INDUCED ACUTE GASTROENTERITIS IN INFANTS

Ngoc Diep Thai1,, Ngoc Rang Nguyen2
1 Can Tho University of Medicine and Pharmacy
2 1Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Backgroud: Rotavirus is the leading cause of acute diarrhea and secondary lactose intolerance in infants. The practice of refeeding lactose-free formula to reduce the duration of diarrhea has not been recommended and remains controversial. In Vietnam, there has been no research on this issue. Objectives: To evaluate the efficacy of lactose-free formula in children aged 2-24 months, had  with acute gastroenteritis caused by Rotavirus at Can Tho Children's Hospital. Materials and methods: A randomized control trial was performed on 46 infants from 2 to 24 months of age with induced-Rotavirus acute gastroenteritis at the Gastroenterology ward of Can Tho Children’s Hospital, excluding children on breastfeeding. Results: A total of 46 children participated in this trial, with a median age was 14 ± 4.9 months, and 28 paticipants (60.9%) were male. There were no significant differences between the lactose-free group and the placebo group in the duration of diarrhea (128.9 ± 19.8 hours and 124.7 ± 25.3 hours, respectively; p = 0.532), the duration of vomiting (47.0 ± 19.5 hours versus 44.2 ± 24.7 hours; p = 0.679), the days of hospitalization (6.8 ± 1.8 versus 8.0 ± 3.9; p = 0.391), and the total score of Vesikari (14.2 ± 2.4 versus 13.7 ± 2.6; p = 0.525) also did not differ between the two groups. Conclusion: Lactose-free formula does not reduce diarrhea duration in children under 24 months with Rotavirus-induced gastroenteritis.

Article Details

Keywords

Lactose-free milk, Rotavirus, gastroenteritis

References

1. Global Burden of Disease Collaborative Network. Cause of death or injury. 2019. https://vizhub.healthdata.org/gbd-results/.
2. World Health Organization. The immunological basis for immunization series: Module 21: Rotavirus vaccines. 2020.
3. Hu Y., Gui L., Chang J., Liu J., Xu S., et al. The incidence of infants with Rotavirus enteritis combined with lactose intolerance. Pakistan journal of pharmaceutical sciences. 2016. 29(1), 321-323.
4. Vesikari T., Hemming-Halo M. Feigin and Cherry’s Textbook of Pediatric Infectious Diseases. Elsevier. 2019. 1592-1601.
5. Vorobiova N., Usachova E. Influence of carbohydrate malabsorption syndrome on the clinical course of Rotavirus infection in children at an early age. Georgian Med News. 2021. (311), 120-125.
6. Tan M.L. N., Muhardi L., Osatakul S., Hegar B., Vandenplas Y., et al. An Electronic Questionnaire Survey Evaluating the Perceived Prevalence and Practices of Lactose Intolerance in 1 to 5 Year Old Children in South East Asia. Pediatric gastroenterology, hepatology & nutrition. 2018. 21(3), 170-175, doi: 10.5223/pghn.2018.21.3.170.
7. MacGillivray S., Fahey T., McGuire W. Lactose avoidance for young children with acute diarrhoea. The Cochrane database of systematic reviews. 2013. (10), doi: 10.1002/14651858.CD005433.pub2.
8. Noreen A., Jalal A., Qudsia. Comparison of Lactose Free With Lactose Containing Formula Milk in the Management of Acute Watery Diarrhoea in Infants. Pakistan Journal Of Medical & Health Sciences. 2016. 10(4), 1337-1339.
9. Dalgic N., Sancar M., Bayraktar B., Pullu M., Hasim O. Probiotic, zinc and lactose-free formula in children with rotavirus diarrhea: are they effective? Pediatrics international : official journal of the Japan Pediatric Society. 2011. 53(5), 677-682, doi: 10.1111/j.1442-200X.2011.03325.x.
10. Lestari S., Firmansyah A., Munasir Z. Double blind clinical trial on a lactose-free and a lactosecontaining formula in the treatment of acute diarrhea in children. Paediatrica Indonesiana. 2006. 46(6), 271-275.
11. World Health Organization. Pocket book of primary health care for children and adolescents:
guidelines for health promotion, disease prevention and management from the newborn period to adolescence. Copenhagen: WHO Regional Office for Europe. 2022.271-299.
12. Al-Dulaimy Z., Al-Sabeea K., Muneam A., Al-Ani K. Lactose Free-Milk for Young Children with Acute Diarrhea, Western of Iraq. Al- Anbar Medical Journal. 2022. 17(2), 68-71.
13. World Health Organization. Pocket book of primary health care for children and adolescents:
guidelines for health promotion, disease prevention and management from the newborn period to adolescence. Copenhagen: WHO Regional Office for Europe. 2022. 511-523.
14. Ruuska T., Vesikari T. Rotavirus Disease in Finnish Children: Use of Numerical Scores for Clinical Severity of Diarrhoeal Episodes. Scandinavian Journal of Infectious Diseases. 1990. 22(3), 259-267, doi: 10.3109/00365549009027046.
15. Hartawan I. N. B., Soenarto S. Y., Suandi I. K. G. Effectiveness of lactose-free formula in management of acute Rotavirus diarrhea. Paediatrica Indonesiana. 2009. 49(5), 299-303.
16. Abdulrazzaq S., Jaafar F. A., Mohammed Z. A. Lactose versus Lactose Free Regimen in Children with Acute Diarrhea. Open Access Macedonian Journal of Medical Sciences. 2021. 9(B), 1279-1282, doi: 10.3889/oamjms.2021.6733.