CHARACTERISTICS AND TREATMENT OUTCOMES OF CHILDREN WITH DIABETES AT CAN THO CHILDREN’S HOSPITAL

Thi Kim Thu Le1,, Cong Ly Tran1, Phuoc Sang Nguyen1, Duc Long Tran1, Van Khoa Le1
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Diabetes mellitus is one of the most common endocrine disorders in children. Objective: To describe the clinical characteristics and evaluate the treatment outcomes of diabetes in children. Materials and Methods: This analytic cross-sectional study was conducted on children diagnosed with diabetes who were admitted to Can Tho Children's Hospital during the research period. Results: In our study, 56.3% of the children were over 10 years old, and 56.3% were female. 91.7% had no family history of diabetes. Common symptoms included significant weight loss (62.5%), polydipsia, polyuria (52.1%), and appetite (35.4%). Other symptoms included nausea/vomiting (35.4%) and abdominal pain (8.3%). Dehydration was present in 20.8% of cases, rapid respiratory rate in 31.3%, and Kussmaul breathing in 25%. Rapid capillary refill time (22.9%), weak pulse, and hypotension (6.3%) were also observed. There is a correlation between the degree of dehydration and the level of ketosis (Spearman ρ=0.579, p=0.019). The median hospitalization duration was 7.9 days, with fluctuations ranging from 5.3 to 12 days. Conclusion: The symptoms of increased appetite, excessive thirst, frequent urination, and weight loss are fully present in pediatric patients with diabetes. It is essential to pay attention to other functional symptoms and signs in children to detect early cases of diabetic ketoacidosis.

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References

1. David R. Weber and Nicholas Jospe. Diabetes Mellitus in Children. In: Nelson Textbook of Pediatrics. Vol 306. ; 2020:3019-3050.
2. Standards of Medical Care in Diabetes—2020 Abridged for Primary Care Providers Clinical Diabetes, American Diabetes Association. Accessed February 25, 2024.
https://diabetesjournals.org/clinical/article/38/1/10/32237/Standards-of-Medical-Care-inDiabetes-2020
3. Magliano DJ, Boyko EJ. IDF Diabetes Atlas. 10th ed. Belgium: International Diabetes Federation; 2022.
4. Libman I, Haynes A, Lyons S, Pradeep P, Rwagasor E, et al. ISPAD Clinical Practice Consensus Guidelines 2022: Definition, epidemiology, and classification of diabetes in children and adolescents. Pediatr Diabetes. 2022. 23(8), 1160-1174, doi:10.1111/pedi.13454
5. Segerer H, Wurm M, Grimsmann JM, Karges B, Neu A, et al. Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence—Incidence and Risk Factors. Dtsch Arztebl Int. 2021. 118(22), 367-372, doi:10.3238/arztebl.m2021.0133.
6. Weissbach A, Zur N, Kaplan E, Kadmon G, Gendler Y, et al. Acute Kidney Injury in Critically Ill Children Admitted to the PICU for Diabetic Ketoacidosis. A Retrospective Study. Pediatr Crit Care Med J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc. 2019. 20(1), e10-e14. doi:10.1097/PCC.0000000000001758.
7. Geme JWS. Nelson Textbook of Pediatrics. Elsevier. 2020.
8. Organization WH. The Treatment of Diarrhoea: A Manual for Physicians and Other Senior Health Workers. World Health Organization; 2005. Accessed April 17, 2024. https://iris.who.int/handle/10665/43209
9. Emmanouilidou E, Galli-Tsinopoulou A, Karavatos A, Nousia-Arvanitakis S. Quality of life of children and adolescents with diabetes of Northern Greek origin. Hippokratia. 2008. 12(3), 168-175.
10. Lawrence JM, Divers J, Isom S, Saydah S, Imperatore G, et al. Trends in Prevalence of Type 1 and Type 2 Diabetes in Children and Adolescents in the US, 2001-2017. JAMA. 2021. 326(8), 717-727, doi:10.1001/jama.2021.11165.
11. Odeh R, Alassaf A, Ajlouni K. Clinical and biochemical features at diagnosis of type 1 diabetes in patients between 0 and 18 years of age from Jordan. Pediatr Diabetes. 2018. 19(4), 707-712, doi:10.1111/pedi.12625.
12. Trần Quang Thanh. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng đái tháo đường type 1 ở trẻ em và kết quả điều trị biến chứng toan ceton tại Bệnh viện Nhi Trung Ương. Đại học Y Hà Nội; 2020.
13. Knowler WC, Pettitt DJ, Savage PJ, Bennett PH. Diabetes incidence in Pima indians:
contributions of obesity and parental diabetes. Am J Epidemiol. 1981. 113(2), 144-156. doi:10.1093/oxfordjournals.aje.a113079.
14. Võ Thị Mỹ Thịnh. Đặc điểm dịch tễ học, lâm sàng, cận lâm sàng điều trị nhiễm toan ceton do đái tháo đường type 1 tại Bệnh viện Nhi Đồng 1. Đại học Y Dược Thành phố Hồ Chí Minh; 2018.
15. Nguyễn Thị Thu Nga. Nghiên cứu một số đặc điểm dịch tễ học lâm sàng, cận lâm sàng và nhận xét kết quả điều trị nhiễm toan ceton ở trẻ đái tháo đường. Luận văn Bác sĩ nội trú. Trường đại học Y Hà Nội; 2012.
16. Rosenbauer J, Icks A, Giani G. Clinical characteristics and predictors of severe ketoacidosis at onset of type 1 diabetes mellitus in children in a North Rhine-Westphalian region, Germany. J Pediatr Endocrinol Metab. 2002. 15(8), 1137-1145, doi:10.1515/jpem.2002.15.8.1137.