ĐÁNH GIÁ ĐỘC TÍNH CẤP, BÁN TRƯỜNG DIỄN CỦA CAO LỎNG QUYÊN TÝ THANG GIA QUẾ CHI, TẠO GIÁC THÍCH TRÊN CHUỘT NHẮT TRẮNG

Abstract

Background: Quyen ty thang increase Cinnamomum, Spina gleditsciae is a remedy which is used in the treatment of musculoskeletal diseases. However, to test a new drug or product on humans, it is necessary to have previous studies confirming its safety and effectiveness on experimental animals. Objectives: To evaluate of acute (LD₅₀) and subchronic oral toxicity of “Quyen ty thang increase Cinnamomum, Spina gleditsciae” in mice. Materials and methods: The experiment procedures were conducted according to recent toxicity evaluation guidelines. Results: LD₅₀ was not found in the oral administration of Quyen ty thang increase Cinnamomum, Spina gleditsciae in mice with the highest oral dose of 225 g/kg. In a semi-chronic study with 2 doses of 21.4g/kg/24h và 64.2g/kg/24h, the preparation did not affect the general condition, body weight of rats, the blood indices, biochemical indices, function, and histopathology of liver, kidney. Conclusions: Quyen ty thang increase Cinnamomum, Spina gleditsciae did not cause acute toxicity in mice with the highest oral dose of 225 g/kg and did not produce any significant toxicity with 2 doses of  21.4g/kg/24h và 64.2g/kg/24h after 90 days.