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Date Published: 26/02/2024
Online Published: 26/02/2024
Abstract Views: 139
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DOI: https://doi.org/10.58490/ctump.2024i71.2311
Issue
No. 71 (2024)
Section
Article
How to Cite
Truong, T. T. T., Dam, N. B., Le, M. K., Le, H. H. Q., Dang, T. H., Truong, T. L. N., Nguyen, H. T., & Tran, T. T. T. (2024). MICE MODEL OF CISPLATIN–INDUCED ACUTE KIDNEY INJURY. Cantho Journal of Medicine and Pharmacy, 71, 96-102. https://doi.org/10.58490/ctump.2024i71.2311

MICE MODEL OF CISPLATIN–INDUCED ACUTE KIDNEY INJURY

Tran Thuc Tran Truong1, Ngoc Bich Dam1, Minh Khoa Le1, Huynh Hoang Quan Le1, Thi Hang Dang1, Thai Lam Nguyen Truong1, Hoang Tin Nguyen1, Thai Thanh Tam Tran1,
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Nowadays, acute kidney injury (AKI) has become more serious, notably in developing countries. The common causes of AKI are often due to the prerenal mechanism of acute kidney injury relating to drug toxicity. Among them, Cisplatin is a drug widely used to treat cancer today, causing one of the most notable adverse drug reactions: acute kidney injury that affects the treatment process and prognosis. Therefore, modeling is necessary to understand the mechanisms and biochemical indicator changes involved in acute kidney injury. Objectives: To determine the characteristics of kidney function in a group of male mice with different doses of Cisplatin intervention and compare with the control group of mice. Materials and methods: Experimental study on male mice, randomly divided into 8 mice/group, including physiological mice and 3 groups of mice with intervention doses of Cisplatin of 10mg/kg, 15mg/kg, and 20mg/kg via intravenous injection, respectively. mouse tail, quantification of blood creatinine and BUN levels after 72 hours. Results: The 15mg/kg intervention group recorded blood creatinine and BUN concentrations 2.59 and 5.07 times higher (p<0.001), 100% of mice suffered acute kidney injury; The 20mg/kg intervention group recorded blood creatinine and BUN concentrations 3.04 and 7.3 times higher (p<0.001), 50% of mice had acute kidney injury, 50% of mice had acute kidney failure. Conclusion: The model of acute kidney injury in mice using Cisplatin has been successfully built at doses of 15mg/kg and 20mg/kg. 

Article Details

Keywords

Cisplatin, acute kidney injury, creatinine, BUN

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