SUY GIÁP THAI KỲ Ở PHỤ NỮ MANG THAI 3 THÁNG ĐẦU TẠI TRUNG TÂM XÉT NGHIỆM Y KHOA YESLAB

Abstract

Background: Pregnancy with endocrine disorders like hypothyroidism can have negative effects on both mother and fetus. In Vietnam, the prevalence of hypothyroidism in the first trimester ranges from 10.9% to 16.3%, resulting in fetal brain damage and potential impact on intellectual development. Objectives: To determine the prevalence of hypothyroidism in pregnant women during the first trimester at Yeslab Medical Testing Center and associated factors. Comparison prevalency of hypothyroidism between the TSH concentration reference range of TOSOH companies and ATA 2017. Materials and methods: Retrospectively reviewed records of 119 pregnant women during first trimester examined at Yeslab Medical Testing Center from September 2022 to May 2023 and had quantitative test results for TSH concentrations. The prevalence of hypothyroidism was determined based on the TSH median in 2 reference ranges: (1) TOSOH company (for Asians) and (2) ATA 2017 guidelines (for first trimester pregnant). Results: Prevalence hypothyroidism according to the two reference ranges TOSOH and ATA 2017 at Yeslab center is 4.2% and 5.9%. Comparing the rate of hypothyroidism in pregnancy between the reference ranges of TOSOH and ATA 2017 recorded in pregnant women aged 30 years and above, the prevalence of hypothyroidism according to TOSOH and ATA 2017 is 2.5%, 0.8% and no difference (p>0.05). For pregnant women under 8 weeks old, the rate of hypothyroidism according to ATA 2017 is higher than TOSOH (5.0%, 3.4%), the difference is statistically significant (p<0.05). TSH concentrations are associated with gestational age but not associated with maternal age. Conclusions: The ATA 2017 guidelines can be used when screening for hypothyroidism. Periodic screening should be performed early to detect thyroid abnormalities and receive timely treatment.