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STUDY OF EPIDEMIOLOGICAL VARIABLES, CLINICAL AND PARACLINICAL FEATURES OF PATIENTS WITH RIFAMPICINRESISTANT PULMONARY TUBERCULOSIS AT CAN THO TUBERCULOSIS AND LUNG DISEASES HOSPITAL
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Abstract
Background: With tuberculosis rising to become the second major cause of mortality and the 13th leading cause of death overall, multidrug-resistant tuberculosis has become a concerning public health issue due to its rapid spread. to infection-related mortality following COVID-19... Objectives: To characterize the Clinical, paraclinical, analyze of a number of factors related to the Rifampicin resistance rate and epidemiological features of patients with pulmonary tuberculosis at Can Tho Tuberculosis and Lung Disease Hospital who are resistant to Rifampicin. Materials and methods: A cross-sectional survey was conducted among 70 Rifampicin-resistant pulmonary tuberculosis patients treated at Can Tho Tuberculosis and Lung Disease Hospital between May 2022 and June 2023. Results: Males made up 87% of the patient population. The majority age group was 40–60 years old (46%). Alcohol and tobacco addiction rates among patients were 34.3% and 63.4%, respectively. Most of the patients had diabetes (30%), with stomach ulcers (20%). The rate of comorbid diabetes in the new Rifampicin-resistant tuberculosis group was 34.4% and the Rifampicin-resistant re-treated tuberculosis group was 26.8%, the difference was not statistically significant (p=0.491). Most patients (95.7%) report having a cough. Tuberculosis cavernous lesions in monoresistant (5.88%) and multiresistant phenotypes (35.8%) were associated with (OR=8.941; CI=1.098-72.784) and (p=0.028). The number of tuberculosis treatments 1 time was 70.5% in mono-resistant cases and 62.2% in multi-resistant cases. There was no statistically significant association between the number of treatments and the tuberculosis resistance phenotype (OR=1.445; CI=0.466-4.743) and (p=0.533). Conclusion: Propaganda and education regarding the risks, signs, and preventative measures for tuberculosis as well as thorough Rifampicin drug resistance must be the main priorities.
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Keywords
Tuberculosis, Rifampicin resistant, G xpert, MTB/RIF
References
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