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Date Published: 12/05/2022
Online Published: 12/09/2022
Abstract Views: 295
Views PDF: 103
DOI: https://doi.org/10.58490/ctump.2022i47.21
Issue
No. 47 (2022)
Section
Article
How to Cite
Huynh , T. M. D., & Le , T. M. N. (2022). Research to improve disolution of celecoxib. Cantho Journal of Medicine and Pharmacy, 47, 65-72. https://doi.org/10.58490/ctump.2022i47.21

Research to improve disolution of celecoxib

Huynh Thi My Duyen1,, Le Thi Minh Ngoc 1
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain. However, celecoxib is poorly soluble in water, so the drug solubility in the stomach is poor and the oral bioavailability is low (about 22-40%). Objectives: Study on the preparation of the solid dispersion of celecoxib with different carrier ratios and analyze the mechanism to improve the solubility of the solid dispersion. Materials and Methods: Celecoxib, excipients used in the preparation of solid dispersions, experimental studies by solvent evaporation, Infrared spectroscopy (FTIR) and Differential scanning calorimetry (DSC) methods to analyze the mechanism of increase the solubility of solid dispersions containing celecoxib. Results: Found the best carrier to improve the solubility of celecoxib and analyzed the mechanism to improve the solubility of solid dispersions.


Conclusions: Celecoxib solid dispersion system using PVP K30 (1:5) carrier system with 2% sodium laurylsulphate, which improves the solubility by 9.1 times, the solubility improvement mechanism is proved by modern analytical methods.

Article Details

Keywords

Celecoxib, β-cyclodextrin, PVP K30, solid dispersion

References

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