RESEARCH ON CLINICAL FEATURES, IMAGING AND THE RELATIONSHIP TO THE SEVERITY OF PATIENTS WITH CEREBRAL INFARCTION AND EXTRACRANIAL CAROTID ARTERY STENOSIS AT S.I.S CAN THO INTERNATIONAL GENERAL HOSPITAL IN 2022-2023

Quang Triet Luong 1, , Chi Cuong Tran 2, Van Tuan Nguyen1
1 Can Tho University of Medicine and Pharmacy
2 S.I.S Can Tho International General Hospital

Main Article Content

Abstract

Background: Cerebral infarction has become a significant medical issue worldwide. However, a group of patients with extracranial carotid artery stenosis has not yet been thoroughly studied, despite its substantial prevalence. Objectives: To describe the clinical features, imaging and investigate the relationship with the severity of cerebral infarction patients with extracranial carotid artery stenosis. Materials and method: A cross-sectional descriptive study was conducted on 30 cerebral infarction patients with extracranial carotid artery stenosis over 18 years of age, who hospitalized and treated at S.I.S Can Tho International General Hospital. Results: The mean age of the study subjects was 64.4 ± 16.1, men accounted for 56.7%. History of hypertension was the major risk factor with 96.3%. All symptoms appear suddenly (100%), of which the most common are hemiparesis (80%) and speech disorders (73.3%). Only 13.3% of patients had old infarcts on CT film, most of them had middle cerebral artery lesions (43.3%) and multiple infarcts (90%). The patients were classified based on the NIHSS, the majority falling into the moderate category (46.7%) followed by severe (36.7%). There was a relationship between outcomes according to mRS and NIHSS subgroup at admission, the difference was statistically significant (p=0.002). Conclusion: Patients with cerebral infarction and extracranial carotid artery stenosis had typical features such as sudden onset, hemiparesis and speech disorders. The image on computed tomography was mainly the first infarction, in many locations from a main cerebral artery branch. Evaluation using NIHSS indicates that most patients have moderate to severe levels of impairment. There was a relationship between severity according to NIHSS scale at admission and outcome according to mRS.

Article Details

References

1. Bộ Y tế. Quyết định số 5331/QĐ-BYT về việc ban hành tài liệu chuyên môn Hướng dẫn chẩn đoán và xử trí đột quỵ não. Văn phòng Bộ Y tế, Hà Nội. 2020.
2. Haverich A., Boyle E.C. Atherosclerosis Risk Factors. Atherosclerosis Pathogenesis and Microvascular Dysfunction. Springer. 2019. 9-45.
3. Murphy S.J., Werring D.J. Stroke: causes and clinical features. Medicine (Abingdon). 2020. 48(9), 561-566. https://doi.org/10.1016/j.mpmed.2020.06.002
4. Chung J.W., Park S.H., Kim N., Kim W.J., Park J.H., et al. Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification and vascular territory of ischemic stroke lesions diagnosed by diffusion-weighted imaging. J Am Heart Assoc. 2014. 3(4):e001119, 1-8. https://doi.org/10.1161/JAHA.114.001119
5. Nguyễn Công Hoan. Nghiên cứu đặc điểm lâm sàng, hình ảnh học của nhồi máu não do xơ vữa hệ động mạch cảnh. Tạp chí Thần kinh học Việt Nam. 2014. 8, 17-22.
6. Nguyễn Bá Thắng, Lê Văn Thành. Đặc điểm hình ảnh học nhu mô não trên 121 bệnh nhân nhồi máu não tắc động mạch cảnh trong. Tạp chí Y Học Thành phố Hồ Chí Minh. 2014. 18(4), 120124. 7. Nguyễn Hạnh Ngân, Nguyễn Trọng Hưng. Lâm sàng, cận lâm sàng và một số yếu tố nguy cơ ở bệnh nhân nhồi máu não cấp có hẹp động mạch cảnh trong đoạn ngoài sọ. Tạp chí Y học Việt Nam. 2023. 522(1), 37-41.
8. Lyden P. Using the National Institutes of Health Stroke Scale: A Cautionary Tale. Stroke. 2017. 48(2), 513-519. https://doi.org/10.1161/STROKEAHA.116.015434
9. Boehme A.K., Esenwa C., Elkind M.S. Stroke Risk Factors, Genetics, and Prevention. Circ
Res. 2017. 120(3), 472-495. https://doi.org/10.1161/CIRCRESAHA.116.308398
10. Fekadu G., Chelkeba L., Kebede A. Risk factors, clinical presentations and predictors of stroke among adult patients admitted to stroke unit of Jimma university medical center, south west Ethiopia: prospective observational study. BMC Neurol. 2019. 19(1):187, 1-11. https://doi.org/10.1186/s12883-019-1409-0
11. Sun W., Li G., Zeng X., Lai Z., Wang M., et al. Clinical and Imaging Characteristics of Cerebral Infarction in Patients with Nonvalvular Atrial Fibrillation Combined with Cerebral Artery Stenosis. J Atheroscler Thromb. 2018. 25(8), 720-732. https://doi.org/10.5551/jat.43240
12. Musuka T.D., Wilton S.B., Traboulsi M., Hill M.D. Diagnosis and management of acute ischemic stroke: speed is critical. CMAJ. 2015. 187(12), 887-93. https://doi.org/10.1503/cmaj.140355
13. Nguyễn Thị Vân Anh, Nguyễn Văn Đàn. Đặc điểm hình ảnh tổn thương động mạch cảnh trong và hệ động mạch sống nền trên cắt lớp vi tính 64 dãy ở bệnh nhân đột quỵ nhồi máu não. Tạp chí Y học Việt Nam. 2022. 517(2), 140-144.
14. Nguyễn Bá Thắng, Vũ Anh Nhị. Tiên đoán hồi phục chức năng trong nhồi máu động mạch não giữa: khảo sát tiền cứu 149 trường hợp. Tạp chí Y học Thành phố Hồ Chí Minh. 2007. 11(1), 314-319.
15. Adams H.P. Jr, Davis P.H., Leira E.C., Chang K.C., Bendixen B.H., et al. Baseline NIH Stroke
Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Neurology. 1999. 53(1), 126-131. https://doi.org/10.1212/wnl.53.1.126.