NGHIÊN CỨU ĐẶC ĐIỂM PHÂN NHÓM PHÂN TỬ UNG THƯ BIỂU MÔ TUYẾN VÚ BẰNG KỸ THUẬT HÓA MÔ MIỄN DỊCH TRÊN BỆNH NHÂN UNG THU BIỂU MÔ TUYẾN VÚ XÂM LẤN TẠI BỆNH VIỆN UNG BƯỚU THÀNH PHỐ CẦN THƠ NĂM 2021-2022

Abstract

Background: Female breast cancer is currently the leading cause of global cancer incidence in 2020. The classification of breast cancer is based on the biological and immunohistochemical properties of tumor cells in order to provide clinical oncology with accurate information, which is the basis for the selection of treatment regimens and disease prognosis. Objectives: To survey on histopathology and rate of molecular subtypes in patients with invasive breast carcinoma at Can Tho City Oncology Hospital in 2021-2022. Materials and methods: Cross-sectional description. Female breast cancer patients with a pathological diagnosis of invasive carcinoma were treated at Can Tho City Oncology Hospital. Results: Through the study of 211 cases of breast carcinoma at Can Tho City Oncology Hospital from August 2021, we have some comments as follows: tubular subgroup A accounts for 39.3%, The Tam Yin subgroup accounted for 24.6%, the HER2 subgroup accounted for 18.5% and the Tubular B subgroup accounted for 17.5%. Molecular subgroup characteristics were statistically significant with histological grade (p=0.041), mitotic index Ki-67 (p<0.001). No association between molecular subtypes with age, cancer stage has been recorded. Conclusion: Luminal A accounts for 39.3%, followed by Triple Negative with 24.6%, followed by HER2 accounting for 18.5% and the lowest Luminal B accounting for 17.5%.