RESEARCH OF BLOOD URIC ACID AND LDH IN PREECLAMPSIA WOMEN IN KIEN GIANG OBSTETRICS AND CHILDREN’S HOSPITAL

My Linh Duong 1,, Thi Thuy Phuong Dang 2
1 Can Tho University of Medicine and Pharmacy
2 Kien Giang Obstetrics and Children's Hospital

Main Article Content

Abstract

Background: Preeclampsia is a common condition in pregnancy with incidence of 2-10%. The disease causes multi-organ damage to pregnant women and seriously affects the fetus. Changes in blood uric acid and LDH in pregnant women can be an early manifestation of preeclampsi. Objective: To determinate serum uric acid and LDH values in pregnant women with pre-eclampsia at Kien Giang Obstetrics and Children's Hospital. Materials and methods: A cross sectional descriptive study in over 143 preeclamptic pregnancies admited in San Nhi Kien Giang hospital from 5/2021 to 6/2022. Results: The mean value of blood uric acid in the group with mild preeclampsia was 367.1 ± 93 µmol/l, in the group with severe preeclampsia 458.3 ± 115 µmol/l. In which, the uric acid value increased > 360 µmol/l, accounting for 41% in the group of mild preeclampsia. Gestational age from 34-<37 weeks with uric acid value >360 µmol/l was 72.7%. The mean value of blood LDH in the mild preeclampsia group was 197,7 ± 61,5 9 u/l; group with severe preeclampsia was 283.7 ± 117.1 u/l; 11.6% of severe preeclampsia, the LDH value is >400u/l. Conclusion: Serum uric acid and LDH levels vary widely with gestational age and severity of preeclampsia.

Article Details

References

1. Cao Ngọc Anh, Trần Mạnh Linh, Võ Văn Đức. Nồng độ Lactate dehydrogenase huyết thanh ở thai phụ tiền sản giật - sản giật và mối liên quan với mức độ nặng của bệnh, kết quả thai kỳ. Tạp chí phụ sản. 2017. 15 (3), 54-60.
2. Bệnh viện Từ Dũ. Tăng huyết áp trong thai kỳ. Phác đồ điều trị sản phụ khoa 2019, Bệnh viện Từ Dũ, Sở Y Tế TP. Hồ Chí Minh. 2019. 79-88.
3. Bộ Y Tế. Tiền sản giật - Sản giật. Hướng dẫn chẩn đoán và điều trị các bệnh Sản phụ khoa. 2015. 29-34.
4. Afroz R., Akhter Q.S., Sadia H. et al. Serum Lactate Dehydrogenase (LDH) Level in Severe Preeclampsia. J. Bangladesh Soc, Physio. 2016. 10(2), pp 71-75.
5. Cunningham FG L. K., et al. Hypertensive Disorders. Williams Obstetrics 24th, 2014. 728-779.
6. Dave A. et al. LDH (Lactate Dehydrogenase): A Biochemical Marker for the Prediction of Adverse Outcomes in Pre-eclampsia and Eclampsia. J Obstet Gynaecol India. 2016. 66 (1), 23-29.
7. Kumar N. et al. Maternal Serum Uric Acid as a Predictor of Severity of Hypertensive Disorders of Pregnancy: A Prospective Cohort Study. Curr Hypertens Rev. 2019. 15 (2), 154-160.
8. Munde S.M, Hazari N.R., Thorat A.P. et al. Gamma Glutamyl Transferase and Lactate Dehydrogenaseas Biochemical Markers of Severity of Preeclampsia. Platelets. 2014. 5, 6.
9. Thangaratinam S, Ismail KM, et al. Tests in Prediction of Pre-eclampsia Severity review group. Accuracy of serum uric acid in predicting complications of pre-eclampsia: a systematic review. BJOG. 2006. 113(4), 369-78. doi: 10.1111/j.1471-0528.2006.00908 PMID: 16553648.
10. Umasatyasri Y., Vani I., Shamita P. Role of LDH (Lactate dehydrogenase) in preeclampsia - eclampsia as a prognostic marker: An observational study. International Archives of Integrated Medicine, 2015. 88.
11. Williams KP, Galerneau F. The role of serum uric acid as a prognostic indicator of the severity of maternal and fetal complications in hypertensive pregnancies. J Obstet Gynaecol Can. 2002. 24(8):628-32. doi: 10.1016/s1701-2163(16)30193-1. PMID: 12196841.