NGHIÊN CỨU BÀO CHẾ VIÊN NANG CHỨA CAO CHIẾT NGHỆ VÀNG, TIÊU ĐEN VÀ GỪNG CÓ TÁC DỤNG KHÁNG VIÊM

Abstract

Background: Osteoarthropathy has become increasingly prevalent, especially among young people. The use of drugs with analgesic and anti-inflammatory effects in the NSAIDs or corticosteroids group can cause various side effects for patients. Therefore, there is a great concern in finding nature-derived products that can help improve disease conditions and limit side effects for patients. Many studies have shown that Curcuma longa, Piper nigrum, and Zingiber officinale Roscoe have anti-inflammatory effects. Objectives: The study aimed to explore the proportion of fillers to ensure good absorption and minimize the content of excipients. This would increase the extract content so that capsules with a small size could still have anti-inflammatory effects, and patients could take fewer capsules at a time. Additionally, the study evaluated the anti-inflammatory effects on a rat paw edema model using a 1% solution of carrageenan. Materials and methods: Curcuma longa, Piper nigrum, and Zingiber officinale Roscoe were extracted by using a suitable method and then evaporated to reduce moisture content as much as possible. A survey was conducted on the amount and types of excipients that could function as fillers and absorb moisture to facilitate the filling of granules into the hard capsules. The anti-inflammatory effects of the hard capsules prepared were evaluated on a rat paw edema model and compared with a control drug containing diclofenac. Results: A hard capsule containing Curcuma longa, Piper nigrum, and Zingiber officinale Roscoe was prepared, consisting of 448 mg of dried nuggets of extracts, 52.7 mg of lactose, 5.5 mg of talc, and 5.5 mg of magnesium stearate. The paw edema test on mice injected at a dose of 70.6 mg/kg showed results of anti-inflammatory effects equivalent to that of the control drug Voltaren® with a dose of 15 mg/kg (p > 0.05). Conclusions: The research has proven that hard capsules containing extracts of Curcuma longa, Piper nigrum, and Zingiber officinale Roscoe have significant anti-inflammatory effects.