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A QUANTITATIVE ASSAY OF G6PD DEFICIENCY IN NEONATAL SCREENING AND DIAGNOSTIC PROGRAM AT CAN THO GYNECOLOGY & OBSTETRICS HOSPITAL FROM 2017 TO 2020
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Abstract
Background: Neonatal screening and diagnosis for Glucose-6-phosphate dehydrogenase (G6PD) deficiency help affected children approach early and appropriate treatments, which can lead them to have normal and healthy life in the future. Objective: To investigate the prevalence of G6PD deficiency and some associated factors among newborns. Subjects and methods: A crosssectional, retrospective descriptive study on 165,964 newborns in the neonatal screening and diagnostic program for 12 provinces of Mekong Delta at Can Tho Gynecology Obstetrics Hospital in the period from 2017 to 2020. Results: The prevalence of confirmed G6PD deficiency cases was 1.02%. Tra Vinh and Soc Trang are two provinces with the highest prevalence. The proportion of boys with the disease was 4 times higher than that of girls (OR= 4.93, p<0.001). Among the three major ethnicities of this region (Kinh, Khmer and Hoa), the Khmer and the Hoa have the highest proportions of the disease at 3.8% and 1.7%, respectively. The difference in ethnicity was statistically significant (p<0.001). When using G6PD deficiency classification based on enzyme activity as the assessment criteria, the study found that there was a difference in the distribution of groups in boys and girls (p<0.001). Conclusion: The proportion of G6PD deficiency in neonates undergoing newborn screening and diagnosis at Can Tho City Obstetrics and Gynecology Hospital was 1.02%. There is a relationship between G6PD deficiency and gender (more affected boys than girls), ethnicity (more affected Khmer and Hoa than Kinh). There is an association between gender and the levels of G6PD activity.
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Keywords
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, newborns, screening
References
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