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Date Published: 12/06/2023
Abstract Views: 501
Views PDF: 268
Issue
No. 26 (2020)
Section
Article
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Doan, D. N., & Ngo, V. T. (2023). SERUM CORTISOL AND OUTCOME IN PATIENTS WITH SEPTIC SHOCK RELATED TO RELATIVE ADRENAL INSSUFICIENCY TREATED BY GLUCOCORTICOID AT ICU DEPARTMENT AT CAN THO CENTRAL GENERAL HOSITAL. Cantho Journal of Medicine and Pharmacy, 26, 75-82. https://tapchi.ctump.edu.vn/index.php/ctump/article/view/1702

SERUM CORTISOL AND OUTCOME IN PATIENTS WITH SEPTIC SHOCK RELATED TO RELATIVE ADRENAL INSSUFICIENCY TREATED BY GLUCOCORTICOID AT ICU DEPARTMENT AT CAN THO CENTRAL GENERAL HOSITAL

Duc Nhan Doan1, , Van Truyen Ngo1
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Septic shock is a critical condition which may threaten life. In case of relative adrenal insufficiency (RAI), treatment would be more complicated. Diagnosing of RAI and interventing opportune with glucocorticoid may occupies an imperative task during treatment. Objectives: To investigate the correlation between serum cortisol and the severity levels on SOFA, APACHE II scale in patients with septic shock related to RAI. To evaluate the outcome of whom were treated by hydrocortisone. Materials and methods: A cross-sectional descriptive study in 86 patients diagnosed of septic shock related to RAI and treated with hydrocortisone at ICU Department in Can Tho Central General Hospital. Results: The ratio of female/male was 1.1/1. Mean age was 67.50 ± 13.94. Mean serum cortisol was 13.63 ± 12.62µg/dl. Patients with serum cortisol <15µg/dl was 57% and ones with that ≥15µg/dl was 43%. There was no significant difference in serum cortisol related by sex (p=0.854) and age (p=0.296). This study has shown the positive significant correlations between serum cortisol and SOFA scale (r=0.369 and p<0.001). Serum cortisol did not correlate with APACHE II scale (p=0.072). Patients with severe status after treated by hydrocortison was 73.3%. Serum cortisol of the improved group and severe one was not significantly different (p=0.674). The severity status significantly correlated with SOFA and APACHE II (p=0.000). Conclusion: Serum cortisol correlated with SOFA scale. Patients who developed worse after treated with hydrocortisone occupied a considerable proportion. Serum cortisol did not make an impact on the outcome.

Keywords

septic shock, relative adrenal insufficiency (RAI), hydrocortisone

Article Details

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