INVESTIGATION ON ANTIBIOTICS USED IN THE TREATMENT OF COMMUNITY-ACQUIRED PNEUMONIA AT A PUBLIC HOSPITAL IN HO CHI MINH CITY
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Abstract
Background: The appropriate use of antibiotics in the treatment of community pneumonia (CAP) plays a very important role in the disease control. Objectives: (1) To investigate the pattern and appropriateness of antibiotics used in the treatment of community-acquired pneumonia and treatment outcomes, and (2) to determine factors associated with the appropriateness of antibiotics used. Materials and methods: A cross-sectional study was conducted to collect medical records of inpatients with CAP aged 18 or older and treated with antibiotics for at least 3 days at the respiratory ward of a public hospital in Ho Chi Minh city, between 1st November 2018 and 29th April 2019. Data collected was patients’ characteristics, antibiotics used and treatment outcomes. The appropriateness of antibiotics used was evaluated using standard guidelines. Logistic regression analysis was used to determine factors associated with the appropriateness of antibiotics used. Results: There were 235 patients (138 males and 97 females) included in the study. Majority of patients were older than 65 years old (median age was 70). Almost all patients had at least one comorbidity. The most common comorbidity was hypertension (63.0%). In 98 (41.7%) patients, antibiotics were indicated in accordance with standard guidelines. -lactam alone or in combination with fluoroquinolone were the most commonly used regimens. The severity of CAP was associated with appropriateness of antibiotics indication. Patients with moderate or severe CAP were more likely to be indicated proper antibiotics regimens than patients with mild CAP (p < 0.05). Conclusions: The appropriateness of antibiotics used in the treatment of CAP in the study hospital was suboptimal. Proper interventions are needed to improve appropriateness of antibiotics used.
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Keywords
antibiotic(s), community-acquired pneumonia (CAP)
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