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Date Published: 12/06/2023
Online Published: 12/06/2023
Abstract Views: 62
Views PDF: 56
Issue
No. 28 (2020)
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Article
How to Cite
Le , N. T. N., Nguyen , T. T., Dang, T. T., Nguyen , Q. L., Tran , V. K., Tran , H. T., Ta, T. V., & Nguyen , V. T. (2023). ASSOCIATION BETWEEN XRCC3 GENE POLYMORPHISM RS1799796 AND OVARIAN CANCER RISK. Cantho Journal of Medicine and Pharmacy, 28, 16-23. https://tapchi.ctump.edu.vn/index.php/ctump/article/view/1612

ASSOCIATION BETWEEN XRCC3 GENE POLYMORPHISM RS1799796 AND OVARIAN CANCER RISK

Nguyen Trong Nhan Le 1,, Thu Thuy Nguyen 1, Thuy Trang Dang2, Quy Linh Nguyen 1, Van Khanh Tran 1, Huy Thinh Tran 1, Thanh Van Ta1, Viet Tien Nguyen 1
1 Hanoi Medical University
2 Camau General Hospital

Main Article Content

Abstract

Background: Ovarian cancer is one of the most common types of gynecological malignancies. The gene XRCC3 involves in HRR (homologous recombinational repair) for DNA damages, which increases the risk of cancer. The gene XRCC3’s polymorphisms and mutations may associate with cancer risk. Objectives: To define the XRCC3 polymorphism rs1799796’s frequencies and its association with ovarian cancer risk. Materials and methods: We performed a case-control study, genotyping of XRCC3 polymorphism rs1799796 in 380 ovarian cancer patients and 380 agematched controls, then analyzed the distributions of the genotypic or allelic frequencies and their association with ovarian cancer risk. Results: The distributions of genotype AA, AG and GG are 34.5%, 49.7%, 15.8% for the patients group and 33.4%, 43.2%, 23.4% for the control group, respectively (p=0.024). There were statistically significant differences between the two research groups when comparing genotypes, and analysis of homozygous and dominant genetic models (p<0.05). Conclusion: The XRCC3 rs1799796 polymorphism was associated with risk of ovarian cancer in Vietnamese females. 

Article Details

Keywords

Ovarian cancer, XRCC3 gene, rs1799796, A17893G, polymorphism

References

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