NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ BỆNH MÀNG TRONG BẰNG BƠM SURFACTANT Ở TRẺ SƠ SINH NON THÁNG TẠI BỆNH VIỆN SẢN NHI AN GIANG 2019-2020

Abstract

Background: Hyaline Membrane Disease is a respiratory distress syndrome in premature infants commonly.  The treatment of using surfactant therapy have positive results for preterm neonate. Objectives: This study aims to describe clinical and subclinical features and treatment of hyaline mambrane disease among preterm neonate at the An Giang hospital of obstetrics, gynecology and pediatrics. Material and methods: A cross-sectional study was conducted on 164 premature infants at the An Giang hospital of Obstretrics, Gynecology and Pediatrics from 3/2019 – 5/2020. Results: 59.8% male was higher than 40.2% female. The average gestational age was 30.7 ± 2.4 weeks and the infant birth weight was 1557.9 ±456.1g. There were 36% patients having severe level of respiratory failure (Silverman score) and 48.8% grade III based on X-ray image. Timely using surfactant has significantly improved the clinical status of respiratory failure, arterial blood gas and grade of hyaline membrane disease based on X-ray (p<0.05). However, the rate of mortality was 52.5% with the highest prevelance of 75% due to sepsis. There were significantly relationship between failure treatment and gestration age of under 28 weeks, birth weight of under 1000g, infants having Silverman score of over 5  and disease grade III and IV based on X-ray. Conclusions: The treatment of hyaline membrane disease using surfactant for preterm neonate showed the positive results and should be implemented to save premature infant lives.