VITAMIN D DEFICIENCY IN PNEUMONIA CHILDREN FROM 2 MONTHS TO 5 YEARS OLD AT CAN THO CHILDREN HOSPITAL IN 2019-2020

Duc Tri Nguyen 1,, Minh Phuong Nguyen 2
1 Can Tho Children Hospital
2 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Severe deficiency of vitamin D causes rickets and hypocalcemia in infants, children, and osteoporosis in adults and adolescents. Objectives: 1) determine vitamin D deficiency and its related factors; 2) identify clinical, subclinical characteristics; and 3) evaluate the treatment outcomes in children with pneumonia from 2 months to 5 years old at Can Tho City Pediatric Hospital, in 2019-2020. Subjects and methods: A cross-sectional study was conducted in 188 childrens from 2 months to 5 years old with pneumonia being treatment at Can Tho Children Hospital, in 2019-2020. Results: The proportion of children with reduced vitamin D, and vitamin D deficiency accounted for 22.3%, 11.7%, respectively. Factors including: exclusively breastfed and exposed to the sun every day showed statistically association with Vitamin D deficiency in children. Subclinical and clinical symptoms: Anemia, wheezing, receding chest, long days of illness, history of pneumonia appear with high frequency in children with reduced vitamin D. Children with reduced vitamin D need more respiratory support, there was significantly more treatment failure in children with very severe pneumonia who had vitamin D deficiency as compared to children without vitamin D deficiency. Conclusions: Vitamin D supplementation for mothers during pregnancy, for infants in the first 6 months, daily sun exposure help reduce the risk of vitamin D deficiency in children, contributing to reducing clinical and subclinical symptoms when pneumonia disease.  

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References

1. Nguyễn Quang Dũng (2014), Thực trạng thiếu vitamin D và các yếu tố liên quan ở trẻ 3-5 tuổi, Tạp chí nghiên cứu y học, 86(1), tr. 73-79.
2. Dusso Adriana S., et al (2005), Vitamin D, Am J Physiol Renal Physiol, 289, p. 8-28.
3. Holick Michael F. (2007), Vitamin D Deficiency, The New England Journal of Medicine, 357, p. 266-281.
4. Hollis B.W. (2005), Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D, J Nutr, 135(2), p. 317-322.
5. Jat Kana Ram (2017), Vitamin D deficiency and lower respiratory tract infections in children: a systematic review and meta-analysis of observational studies, Tropical Doctor, 47(1), p. 77–p84.
6. Jia Kun-Peng, et al (2017), Lower level of vitamin D3 is associated with susceptibility toacute lower respiratory tract infection (ALRTI) and severity: a hospital based study in Chinese infants, Int J Clin Exp Med, 10(5), p. 7997-8003.
7. Kochupillai N. (2008), The physiology of vitamin D: Current concepts, Indian J Med Res, p. 256-262.
8. Laaksi Ilkka, et al (2010), Vitamin D Supplementation for the Prevention of Acute Respiratory Tract Infection: A Randomized, Double-Blinded Trial among Young Finnish Men, The Journal of Infectious Diseases, 202(5), p. 809-814.
9. Martineau Adrian R, et al (2017), Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ, 356.
10. Misra M, et al (2008), Vitamin D deficiency in children and its management: review of current knowledge and recommendations, Pediatrics, 122(2), p. 398-417.
11. Mohamed Wahab W.A, Al-Shehri M.A. (2012), Cord blood 25-hydroxyvitamin D levels and the risk of acute lower respiratory tract infection in early childhood, Journal of Tropical Pediatrics, 59(1), p. 29-35.
12. Nguyen Minh Phuong, et al (2020), Vitamin D and bone mineral density status, and their correlation with bone turnover markers in healthy children aged 6–14 in Vietnam, Curr Pediatr Res, 24(3), p. 203-208.
13. Oduwole A.O., et al (2010), Relationship between Vitamin D Levels and Outcome ofPneumonia in Children, West African Journal of Medicine, 29(6), p. 373-378.
14. Prentice Ann (2016), Vitamin D and Health, Scientific Advisory Committee on Nutrition.