TÌNH HÌNH SỬ DỤNG THUỐC KHÁNG SINH VÀ YẾU TỐ LIÊN QUAN TẠI KHOA NGOẠI - BỆNH VIỆN ĐA KHOA TỈNH TRÀ VINH, NĂM 2019

Abstract

Background: Incorrect use and abuse of antibiotics are a major threat to public health, increasing drug resistance and increasing healthcare costs. Objectives: Characteristics and some factors related to antibiotic use at Surgery Department, Tra Vinh General Hospital. Subjects and methods: Retrospective cross-sectional study of 400 medical records using antibiotics for ≥ 3 days at the surgical department of Tra Vinh General Hospital. Results: Having performed surgery 87.8% and 54.8% using prophylactic antibiotics. The most commonly used antibiotics are Beta-lactam, the two most commonly used families are the narrow and medium penicillins, accounting for 35.4% and the 1.2 generation Cephalosporins, accounting for 78.5%. In addition, some other groups of antibiotics are used quite commonly in the Surgery Department of the hospital such as Aminoglycoside 55.25% and 5-nitroimidazole 37.25%. Average number of drugs: 2.7 ± 1.1. The average time of antibiotic use in hospital: 6.38 ± 3.1. The route used most often is a combination of injection - infusion and oral form, accounting for 37.8%. Factors related to the number of antibiotic use (p < 0.05): sex (OR = 2.3; 95%CI: 1.5 - 3.5), infection status (OR = 4.9; 95%CI: 3.1 - 7.7), surgery (OR = 6.2; 95%CI: 2.9 - 13.3). Factors related to the duration of antibiotic use (p < 0.05): sex (OR = 1.8; 95%CI: 1.1 - 3.1), occupation (OR = 12.5; 95%CI: 1.7 - 91.9), length of hospital stay (OR = 29.9; 95%CI: 12.5 - 71.1), surgery (OR = 3.2; 95%CI: 1.7 - 6.2), using prophylactic antibiotics (OR = 2.3; 95%CI: 1.2 - 4.3). Conclusion: Gender, occupation and condition factors increase the number and duration of antibiotic use.