NGHIÊN CỨU TÌNH HÌNH SỬ DỤNG KHÁNG SINH TRONG ĐIỀU TRỊ NGOẠI TRÚ Ở MỘT BỆNH VIỆN TẠI THÀNH PHỐ CẦN THƠ

Abstract

Background: Problems that emerged from the inappropriate use of antibiotics of outpatients can affect the safety and effectiveness of treatment, especially increasing bacterial resistance. Objectives: To determine the characteristics of antibiotic use and to evaluate the appropriateness in outpatient treatment. Materials and  methods: A cross-sectional study was conducted on 420 outpatient prescriptions with antibiotics at an examination department of a hospital in Can Tho city (from August 1, 2019 to January 31, 2020). We evaluated the appropriateness of antibiotics use according to leaflets of medications, Vietnamese National Drug Formulary, and the current antimicrobial guidelines issued by the Ministry of Health. Results: Penicillins were the most commonly used antibiotic group, accounting for 49.2%, followed by .cephalosporins 33.1%, the lowest was cyclin with 3.6%. The number of antibiotics prescribed in a treatment course is mostly one with 97.1%. Among the indicators of  antibiotic use, accounting for the highest inappropriate proportion was the timing of administration (68.1%), followed by dosage frequency (11.0%), and dosage (9.5%). Serious interactions between antibiotics and other drug groups were recorded in 13 cases (3.1%). The most common serious drug interaction was the one between levofloxacin and tramadol. Conclusions: The rate of inappropriate timing of antibiotic administration was still high. Clinical significance evaluation and appropriate interventions should be assessed to ensure safe, effective, and economical use of antibiotics.