TƯƠNG TÁC THUỐC TRÊN BỆNH NHÂN CAO TUỔI ĐIỀU TRỊ NỘI TRÚ TẠI KHOA NỘI TIM MẠCH - LÃO HỌC BỆNH VIỆN ĐA KHOA THÀNH PHỐ CẦN THƠ NĂM 2022

Abstract

Background: Drug interactions have significant importance in treatment. The consequences of drug interactions are changes in the drugs effects or toxicity when used simultaneously with other drugs, herbs, foods, drinks, or other chemicals, and are one of the causes of adverse drug reactions, including toxicity or harmful reactions during use, treatment failure, and even death. Objectives: (1) Determine the characteristics of drug use in elderly inpatients treated at the Cardiology-Geriatrics Department of Can Tho City General Hospital; (2) Determine the proportion and severity of drug interactions in the medication orders. Materials and methods: A cross-sectional descriptive study was conducted on 382 medical records from the CardiologyGeriatrics Department of Can Tho City General Hospital from June 1, 2022, to December 31, 2022. The website www.medscape.com was used to check drug interactions. Results: 144 medical records had drug interactions with 80 pairs and 391 interactions identified. The highest proportion was moderate interactions at 73.8% followed by severe interactions at 20.0% mild interactions at 5.0%, and contraindicated interactions at 1.2%. The highest proportion of drug interaction pairs is accounted for by pharmacokinetic mechanisms at 65.0% (52 pairs), followed by pharmacodynamic drug interactions at 26.2% (21 pairs), and a portion of pairs with an undetermined mechanism constituting 8.8% (7 pairs). Conclusions: The research results will serve as a foundation to help healthcare personnel have a more comprehensive view of drug use, strengthen pharmacotherapy practice at the hospital, reduce the risk of unwanted effects from drug interactions, ensure prescription efficacy and treatment outcomes at the hospital.