Hair growth promoting effect of essential oil from grapefruit peel (citrus grandis) combine dried gleditsia sinensis's extract powder on a shaved white mice model

Nguyen Pham Hong Thanh1,, Nguyen Ngoc Quynh2, Le Ngoc Lan Vi 2, Tran Thi Ngoc Tran 2
1 Can Tho Medical College
2 Can Tho University of Medicine and Pharmacy

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Abstract

Background: Many people are experiencing hair loss problems such as excessive hair loss, thinning hair and especially baldness. There are many ways to overcome this, one of which is to use hair care products that help stimulate hair growth, reduce hair loss and make hair stronger.


Objectives: To evaluate the hair growth promoting effect of Grapefruit essential oil product containing Citrus grandis peel essential oil combined with dried Gleditsia sinensis’s extract powder on a shaved white mice model. Materials and methods: 07-week-old male white mice were marked with dorsal skin and hair removed with a specialized hair removal tool. Grapefruit peel is extracted by steam distillation and is used to prepare grapefruit peel essential oil product. Minoxidil 5% and physiological saline were used as controls. Grapefruit essential oil product, minoxidil and physiological saline are applied daily on the shaved back skin after bathing with clean water.


Results: Research show that the hair growth in mice using Grapefruit essential oil product is faster than that in mice without using, p<0.05. Hair length was also significantly improved in mice after using Grapefruit essential oil product (25% of the batch). With a significance level of 91%, it was found that using Grapefruit essential oil product or minoxidil increased the number of hairs significantly. Conclusions: The use of Grapefruit essential oil product on mice shows that Grapefruit essential oil product has the ability to improve hair condition, helping hair grow faster, more and longer.

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References

1. Trần Trường Giang, Huỳnh Ngọc Trinh (2019), “Khảo sát tác dụng kích thích mọc lông của kem từ cao lá tía tô trên mô hình chuột nhắt rụng lông gây bởi cyclophosphamid”, Tạp chí Y Dược học Cần Thơ, tr.22-25.
2. Geun-Shik Lee, Eui-Ju Hong, Ki-Seob Gwak, Mi-Jin Park, et al. (2010), “The essential oils of Chamaecyparis obtusa promote hair growth through the induction of vascular endothelial growth factor gene”, Fitoterapia, 81, pp.17-24.
3. Guang-Ri Jin, Yi-Lin Zhang, Jonathan Yap, William A. Boisvert, BogHieu Lee (2020), “Hair growth potential of Salvia plebeia extract and its associated mechanisms”, Pharmaceutical Biology, 58(1), pp.400-409.
4. Ma J, et al. (2018), “In vivo evaluation of insect wax for hair growth potential”, PLoS One, 13(2).
5. Poh-Ching Tan, et al. (2020), “Autologous Concentrated Growth Factors Combined with Topical Minoxidil for the Treatment of Male Androgenetic Alopecia: A Randomized Controlled Clinical Tria”, Facial Plastic Surgery & Aesthetic Medicine, 23(3).
6. Rambwawasvika H, Dzomba P, Gwatidzo L. (2019), “Hair Growth Promoting Effect of Dicerocaryum senecioides Phytochemicals”, Int J Med Chem.
7. Suchonwanit P, Srisuwanwattana P, Chalermroj N, Khunkhet S (2018), “A randomized, double-blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil vs. 3% minoxidil solution in the treatment of male androgenetic alopecia.”, J Eur Acad Dermatol Venereol , 32(12), pp.2257-2263.
8. Van-Long Truong, Min Ji Bak, Changook Lee, Mira Jun, Woo-Sik Jeong (2017), “Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone- Induced Delay of Anagen Entry in C57BL/6 Mice”, Molecules, 22(1505).