NGHIÊN CỨU TÁC DỤNG BẢO VỆ GAN CỦA CAO CHIẾT NẤM VÂN CHI ĐỎ (PYCNOPORUS SANGUINEUS) BẰNG MÔ HÌNH GÂY TỔN THƯƠNG GAN IN VIVO

Abstract

Background: Medicinal mushrooms of the Pycnoporus sanguineus with very high medicinal properties are one of the 25 main species of mushrooms in the world that are widely used by many people. The fungus is rich in biologically active substances such as flavonoids, polyphenols, saponins. However, at present, there are not many pharmacological studies of this mushroom. Objective: To study the hepatoprotective effect of the extract of the Pycnoporus sanguineus with a carbon tetrachloride-induced liver injury model. Materials and methods: Extract of the fruit body of the Pycnoporus sanguineus MH225776. Investigation of hepatoprotective pharmacological effects on a mouse liver injury model using CCl₄. Results: In an experimental model, the extract of Ganoderma lucidum was effective in protecting the liver from chronic toxicity by CCl₄. Conclusion: At doses of 500mg/kg and 1000mg/kg, Pycnoporus sanguineus extract had hepatoprotective effects in a chronic toxicity model by CCl₄ in white mice.