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Date Published: 12/07/2023
Online Published: 17/07/2023
Abstract Views: 303
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DOI: https://doi.org/10.58490/ctump.2023i61.1265
Issue
No. 61 (2023): HỘI NGHỊ THƯỜNG NIÊN HỌC VIÊN – SINH VIÊN NGHIÊN CỨU KHOA HỌC NĂM 2023
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Article
How to Cite
Dinh, V. T., Ho, L. H., Pham, V. L., Lam, H. H., Lu, H. P., & Dang, Q. T. (2023). RADIOFREQUENCY ABLATION OF HEPATOCELLULAR CARCINOMA AT CAN THO IN 2021-2023. Cantho Journal of Medicine and Pharmacy, 61, 155-162. https://doi.org/10.58490/ctump.2023i61.1265

RADIOFREQUENCY ABLATION OF HEPATOCELLULAR CARCINOMA AT CAN THO IN 2021-2023

Van Thai Dinh1,, Ho Long Hien2, Pham Van Linh3, Lam Hoang Huan4, Lu Hoang Phi5, Dang Quang Tung2
1 Can Tho University of Medicine and Pharmacy
2 Can Tho Oncology Hospital
3 Hong Bang International University
4 Can Tho University of Medicine and Pharmacy Hospital
5 Can Tho Central General Hospital

Main Article Content

Abstract

Background: Radiofrequency ablation is one of the radical treatments for early-stage hepatocellular carcinoma. In Can Tho, radiofrequency ablation has been implemented in several hospitals, however there are not many studies that fully evaluate the treatment results. Objectives: 1) To determine clinical and subclinical features of hepatocellular carcinoma; 2) To evaluate the treatment results for hepatocellular carcinoma by radiofrequency ablation at Can Tho Central General Hospital, Can Tho Oncology Hospital and Can Tho University of Medicine and Pharmacy Hospital. Materials and methods: This was a prospective, cross-sectional study on 42 patients with hepatocellular carcinoma who were treated with radiofrequency ablation. Results: The mean age of the patients: 63 ± 10 years old. Male/female: 2.5/1. Median of AFP: 8.49 ng/mL. The mean tumor size: 2.75 ± 0.96 cm. Mean number of ablations for each tumor: 1.7 ± 1.3 times. Mean time of ablation for each tumor: 24.8 ± 14.5 minutes. Overall complication was 4.8%. The mean duration of hospital stays: 1.5 ± 0.9 days. The rate of complete necrosis of the tumor after 1 month was 85.1%. The complete response after ablation at 1 month, 3 months, 6 months and 12 months was 83.3%, 80.5%, 80.6% and 68.2%, respectively. The 1-year survival rate was 87.5%. Conclusion: Radiofrequency ablation of hepatocellular carcinoma is safe and effective.

Article Details

Keywords

hepatocellular carcinoma, radiofrequency ablation, radical treatment

References

1. Llovet J. M., Kelley R. K., Villanueva A., Singal A. G., Pikarsky E., et al. Hepatocellular carcinoma. Nature Review. 2021. 7(1), 6, doi: 10.1038/s41572-020-00240-3.
2. Đào Việt Hằng. Đánh giá kết quả điều trị ung thư biểu mô tế bào gan bằng đốt nhiệt sóng cao tần với các loại kim được lựa chọn theo kích thước khối u. Trường Đại học Y Hà Nội. 2016. 81.
3. Bộ Y tế. Hướng dẫn chẩn đoán và điều trị ung thư biểu mô tế bào gan. 2020. 11.
4. Sangiovanni A., Colombo M. Treatment of hepatocellular carcinoma: beyond international guidelines. Liver Int. 2016. 36, 124-129, doi: 10.1111/liv.13028.
5. Võ Hội Trung Trực, Nguyễn Đình Song Huy, Võ Duy Thuần. Nghiên cứu phương pháp phá hủy bằng sóng radio ung thư biểu mô tế bào gan có kích thước không quá 5 cm. Tạp chí Y Học Thành phố Hồ Chí Minh. 2013. 17, 358-362.
6. Nguyễn Cao Cương, Trần Vĩnh Hưng, Võ Thiện Lai, Phạm Vinh Quang. Nghiên cứu kết quả sớm điều trị ung thư biểu mô tế bào gan bằng sóng cao tần. Hội Gan Mật Việt Nam. 2018.
7. Bale R., Schullian P., Eberle G., Putzer D., Zoller H., et al. Stereotactic radiofrequency ablation of hepatocellular carcinoma: a histopathological study in explanted livers. Hepatology. 2019. 70(3), 840-850, doi: 10.1002/hep.30406.
8. Hoàng Ngọc Tấn, Vũ Hồng Thăng, Nguyễn Thị Thu Huyền. Kết quả sớm điều trị ung thư biểu mô tế bào gan bằng đốt nhiệt sóng cao tần. Tạp chí Y học Việt Nam. 2022. 515 (1), 53-58, doi: 10.51298/vmj.v515i1.2673.
9. Takayama T., Hasegawa K., Izumi N., Kudo M., Shimada M., et al. Surgery versus radiofrequency ablation for small hepatocellular carcinoma: A randomized controlled trial (SURF Trial). Liver Cancer. 2022. 11(3), 209-218, https://doi.org/10.1159/000521665.
10. Lee M. W., Kang D., Lim H. K., Cho J., Sinn D. H., et al. Updated 10-year outcomes of percutaneous radiofrequency ablation as first-line therapy for single hepatocellular carcinoma < 3 cm: emphasis on association of local tumor progression and overall survival. European Radiology. 2020. 30, 2391-2400, doi: 10.1007/s00330-019-06575-0.
11. Lee D. H., Lee M. W., Kim P. N., Lee Y. J., Park H. S., et al. Outcome of no-touch radiofrequency ablation for small hepatocellular carcinoma: a multicenter clinical trial. Radiology. 2021. 301(1), 229-236, doi: 10.1148/radiol.2021210309.
12. Phạm Xuân Đông, Phan Hải Thanh, Nguyễn Thanh Xuân. Đánh giá kết quả điều trị ung thư biểu mô tế bào gan không có khả năng cắt bỏ bằng đốt sóng cao tần có gây mê dưới hướng dẫn của siêu âm. Tạp chí Y Dược lâm sàng 108. 2022. 17, 198-207, doi: 10.52389/ydls.v17iDB.1286.
13. Kim W., Cho S., Shin S. W., Hyun D., Lee M. W. et al. Combination therapy of transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for small hepatocellular carcinoma: comparison with TACE or RFA monotherapy. Abdominal Radiology. 2019. 44, 2283-2292, doi: 10.1007/s00261-019-01952-1.