KHẢO SÁT MỐI TƯƠNG QUAN GIỮA CÁC CÔNG THỨC ƯỚC ĐOÁN ĐỘ LỌC CẦU THẬN VỚI ĐỘ THANH THẢI CREATININE 24 GIỜ CỦA SINH VIÊN Y KHOA TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ

Abstract

Background: Glomerular filtration rate is an important indicator to evaluate kidney function. From the estimation formulas Cockroft - Gault, MDRD and CKD - EPI creatinine 2021 choose the best formula for routine assessment of kidney function in young subjects. Objectives: 1) To describe estimated glomerular filtration rate characteristics according to age, sex, and anthropometric characteristics of medical students of Can Tho University of Medicine and Pharmacy; 2) Determine the correlation between estimated glomerular filtration rate equations and 24-hour creatinine clearance of medical students of Can Tho University of Medicine and Pharmacy. Materials and methods: A descriptive cross-sectional study was conducted on a total of 110 medical students of Can Tho University of Medicine and Pharmacy from 18 to 29 years old,  from June 2021 to June 2022. Results: The mean age of the subjects was 23.3 ± 3.1  years; 47.3% male students. The mean glomerular filtration rate in total was 119.1 ± 5.9 (mL/min/1.73m²). When dividing groups by age, gender, or anthropometric indexes, the formula CKD - ​​EPI creatinine 2021 has the closest correlation with 24-hour creatinine clearance. The CKD – EPI creatinine 2021, MDRD and Cockroft – Gault equations correlated with 24-hour creatinine clearance, and the correlation coefficients were 0.819; 0.386; -0.315; respectively. Conclusions: For routine assessment of glomerular filtration rate in young people, we found that CDK – EPI creatinine 2021 equation had better results than MDRD and Cockroft – Gault equations.