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CLINICAL, SUBCLINICAL AND SHORT-TERM MORTALITY PROGNOSTIC VALUE OF HYPONATREMIA IN PATIENTS WITH HEART FAILURE REDUCED EJECTION FRACTION AT CAN THO CENTRAL GENERAL HOSPITAL 2022-2023
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Abstract
Background: Heart failure is one of the most common major diagnoses and places a great burden for health care systems. Hyponatremia is an independent predictor of mortality for patients with heart failure, especially in group with reduced ejection fraction. Objectives: To describe clinical, subclinical features and survey the prognostic value of mortality within 60 days after discharge of hyponatremia in patients with heart failure with reduced ejection fraction at Can Tho Central General Hospital 2022-2023. Materials and methods: A cross-sectional with a follow-up study was carried out on 108 patients with heart failure with reduced ejection fraction at Cardiovascular Center – Can Tho Central General Hospital. Results: The median blood sodium concentration was 136 mmol/L, the minimum value was 104 mmol/L and the maximum value was 145 mmol/L. The value of serum sodium concentration in the prognosis of 60-day mortality in patients with heart failure reduced ejection fraction at the cut-off point 130 mmol/L had a sensitivity of 97.8%, a specificity of 61.1%, AUC of 0.855. Conclusions: Hyponatremia has the potential to predict mortality within 60 days after discharge in patients with heart failure reduced ejection fraction.
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Keywords
Heart failure, hyponatremia, prognosis
References
2. Aliyeva F., Belkin M. and Wussler D. Prevalence, patient characteristics and outcome of hyponatremia in acute heart failure. European Heart Journal. 2022. 43, 1072.
3. Ishikawa S. Hyponatremia Associated with Congestive Heart Failure: Involvement of Vasopressin and Efficacy of Vasopressin Receptor Antagonists. J Clin. 2023. 12, 1482, doi: 10.3390/jcm12041482.
4. Klein L., O’Connor CM. and Leimberger JD. Lower Serum Sodium Is Associated With Increased Short-Term Mortality in Hospitalized Patients With Worsening Heart Failure Results From the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) Study. American Heart Association Journals. 2005. 111, 2454-2460. doi: 10.1161/01.CIR.0000165065.82609.3D.
Teerapat Y., Tao-Cheng W. and Dong-jung C. Economic Burden of Heart Failure in Asian Countries with Different Healthcare Systems. Korean Circ J. 2021. 51, 581-593, doi: 10.4070/kcj.2021.0029.
2. Aliyeva F., Belkin M. and Wussler D. Prevalence, patient characteristics and outcome of hyponatremia in acute heart failure. European Heart Journal. 2022. 43, 1072.
3. Ishikawa S. Hyponatremia Associated with Congestive Heart Failure: Involvement of Vasopressin and Efficacy of Vasopressin Receptor Antagonists. J Clin. 2023. 12, 1482, doi: 10.3390/jcm12041482.
4. Klein L., O’Connor CM. and Leimberger JD. Lower Serum Sodium Is Associated With Increased Short-Term Mortality in Hospitalized Patients With Worsening Heart Failure Results From the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) Study. American Heart Association Journals. 2005. 111, 2454-2460. doi: 10.1161/01.CIR.0000165065.82609.3D.
5. Gheorghiade M., Rossi J. and Cotts W. Characterization and Prognostic Value of Persistent Hyponatremia in Patients With Severe Heart Failure in the ESCAPE Trial. ARCH INTERN MEDICAL. 2007. 167, 1998-2005. doi: 10.1001/archinte.167.18.1998.
6. European Society of Cardiology. Guidelines for the diagnosis and treatment of acute and chronic heart failure. European Heart Journal. 2021. 42, 3599-3726.
7. Đỗ Thị Nam Phương, Nguyễn Anh Duy Tùng. Khảo sát các yếu tố tiên lượng tử vong trên bệnh nhân suy tim phân suất tống máu giảm nhập viện tại Viện tim Thành phố Hồ Chí Minh. Đại Học Y Dược Thành Phố Hồ Chí Minh. 2019. 105.
8. Saepudin H., Patrick A. and Morrissey H. Hyponatremia during hospitalization and in-hospital mortality in patients hospitalized from heart failure. BMC Cardiovascular Disorders. 2015. 15, 88.
9. Grey C. The Acute Decompensated Heart Failure National Registry (ADHERE): opportunities to improve care of patients hospitalized with acute decompensated heart failure. Rev Cardiovasc Med. 2003. 7, 21-30, doi: 10.1186/s12872-015-0082-5.
10. Yang S., Mengqiu M. and Hengbin Z. Prognostic value of serum hyponatremia for outcomes in patients with heart failure with preserved and reduced ejection fraction: An observational cohort study. Experimental and Therapeutic Medicine. 2020. 20(5), 1792-1801, doi: 10.3892/etm.2020.9231.
11. Alexandru C., Stela I. and Andrea M. Hyponatremia and Renal Venous Congestion in Heart Failure Patients. Dis Markers. 2021. 2021, 9, doi: 10.1155/2021/6499346.
12. Nikolaidou T., Samuel N. and Marincowitz C. Electrocardiographic characteristics in patients with heart failure and normal ejection fraction: A systematic review and meta‐analysis. Ann Noninvasive Electrocardiol. 2019. 25, 127.
13. Jones NR., Roalfe AK. and Adoki I. Survival of patients with chronic heart failure in the community: a systematic review and meta-analysis. European journal of heart failure. 2019. 21,1306-1325, doi: 10.1111/anec.12710.
14. Triệu Khánh Vinh. Các yếu tố tiên lượng tử vong hoặc tái nhập viện trong vòng 30 ngày sau xuất viện trên bệnh nhân suy tim. Tạp Chí Y học Việt Nam. 2022. 520, 114-119.
15. Abebe B., Gebreyohannes E. and Tefera Y. The prognosis of heart failure patients: Does sodium level play a significant role? PLoS One. 2019. 13(11), 14, doi: 10.1371/journal.pone.0207242.
16. Nam-Kyoo L., Sang Eun L. and Haeyoung L. Risk prediction for 30-day heart failure-specific readmission or death after discharge: Data from the Korean Acute Heart Failure (KorAHF) registry. J Cardiol. 2019. 73, 108-113, doi: 10.1016/j.jjcc.2018.07.009.