EVALUATION OF TREATMENT OUTCOMES AND THE PROGNOSTIC VALUE OF SERUM PROCALCITONIN, CRP AND D-DIMER LEVELS IN PATIENTS WITH ACUTE PANCREATITIS AT VINH LONG GENERAL HOSPITAL
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Abstract
Background: Acute pancreatitis (AP) represents a critical medico-surgical emergency featuring rapid onset and intricate disease trajectories that significantly jeopardize patient outcomes. Emerging evidence highlights the prognostic utility of serum Procalcitonin, C-reactive protein (CRP), and D-dimer in forecasting AP progression early. Objectives: To assess clinical outcomes and determine the predictive performance of serum Procalcitonin, CRP, and D-dimer levels in AP patients managed at Vinh Long General Hospital. Materials and methods: A crosssectional analytical study was carried out on 40 AP patients admitted to the Department of Gastroenterology, Vinh Long General Hospital, between September 2025 and January 2026. Results: The mean patient age was 45.2 ± 20.3 years (range: 18–87), with a male predominance of 72.5%. Moderately severe and severe AP cases constituted 70% of the cohort. The average length of stay was 8.2 ± 3.0 days, with zero overall mortality. In predicting severe AP, CRP yielded an AUC of 0.790 (sensitivity 64%, specificity 66%, 95% CI: 0.051–0.870); Procalcitonin demonstrated an AUC of 0.704 (sensitivity 67%, specificity 83%, 95% CI: 0.052–0.880); and D-dimer achieved the highest discriminative power with an AUC of 0.804 (sensitivity 92%, specificity 50%, 95% CI: 0.650–0.950). Conclusion: Serum procalcitonin, CRP and D-dimer levels possess high clinical value in predicting the prognosis of moderately severe and severe acute pancreatitis.
Keywords
Procalcitonin, CRP, D-dimer, acute pancreatitis
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