MOTOR COMPLICATIONS AND ASSOCIATED FACTORS IN PARKINSON’S DISEASE PATIENTS IN CAN THO CITY
Main Article Content
Abstract
Background: Parkinson's disease is a progressive neurodegenerative disorder in which motor complications frequently develop and significantly impair patients’ quality of life. Objective: To determine the prevalence of motor complications and identify associated factors in patients with Parkinson’s disease. Materials and methods: A cross-sectional descriptive study was conducted on 90 patients diagnosed according to the criteria of the International Parkinson and Movement Disorder Society at Can Tho Central General Hospital from July 2024 to February 2026. Results: Among 90 patients, 60% were female. The mean age was 72.7 ± 11.7 years, mean age at onset 64.6
± 9.8 years, and mean disease duration 8.0 ± 4.2 years. The prevalence of motor complications was 73.3%. Wearing-off was the most common (28.8%), on–off phenomenon (20%), followed by delayed-on (15,6%), and dyskinesia (8.8%). The mean MDS-UPDRS III score was significantly higher in patients with motor complications (39.9 ± 7.4) compared to those without (p < 0.001). Motor complications were associated with longer disease duration, prolonged levodopa use, higher levodopa dose, and advanced disease stage. Conclusion: Motor complications are common in Parkinson’s disease, with motor fluctuations occurring more frequently than dyskinesia. Wearingoff was the predominant pattern. Longer disease duration, extended levodopa exposure, higher dosage, and advanced stage were strongly associated with motor complications.
Keywords
Motor fluctuations, Dyskinesia, Parkinson’s disease
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
2. Thanvi B, Lo N, Robinson T. Levodopa-induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment. Postgrad Med J. 2007. 83(980), 384-8. https://doi.org/10.1136/pgmj.2006.054759.
3. Espay AJ, Morgante F, Merola A, et al. Levodopa-induced dyskinesia in Parkinson disease: Current and evolving concepts. Ann Neurol. 2018. 84(6), 797-811. https://doi.org/10.1002/ana.25364.
4. Stocchi F, Antonini A, Barone P, et al. Early Detection of wearing off in Parkinson disease: the DEEP study. Parkinsonism Relat Disord. 2014. 20(2), 204-11. https://doi.org/10.1016/j.parkreldis.2013.10.027.
5. Tran TN, Vo TNN, Frei K, Truong DD. Levodopa-induced dyskinesia: clinical features, incidence, and risk factors. J Neural Transm (Vienna). 2018. 125(8), 1109-1117. https://doi.org/10.1007/s00702-018-1900-6.
6. Chen W, Xiao Q, Shao M, et al. Prevalence of wearing-off and dyskinesia among the patients with Parkinson's disease on levodopa therapy: a multi-center registry survey in mainland China. Transl Neurodegener. 2014. 3(1), 26. https://doi.org/10.1186/2047-9158-3-26.
7. Bjornestad A, Forsaa EB, Pedersen KF, Tysnes OB, Larsen JP, Alves G. Risk and course of motor complications in a population-based incident Parkinson's disease cohort. Parkinsonism Relat Disord. 2016, 22, 48-53. https://doi.org/10.1016/j.parkreldis.2015.11.007.
8. Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord. 2015. 30(12), 1591-601. https://doi.org/10.1002/mds.26424.
9. Thanh Hùng T, Anh Nhị V, Xuân Cảnh N. Mối liên quan giữa biến chứng vận động và tình trạng chậm làm trống dạ dày trong bệnh Parkinson. Tạp chí Y học Việt Nam. 2021. 503(2). https://doi.org/10.51298/vmj.v503i2.764.
10. Sun B, Wang T, Li N, Qiao J. Analysis of Motor Complication and Relative Factors in a Cohort of Chinese Patients with Parkinson's Disease. Parkinsons Dis. 2020. 8692509. https://doi.org/10.1155/2020/8692509.
11. Gandhi SE, Zerenner T, Nodehi A, et al. Motor Complications in Parkinson's Disease: Results from 3343 Patients Followed for up to 12 Years. Mov Disord Clin Pract. 2024. 11(6), 686-697. https://doi.org/10.1002/mdc3.14044.