ĐẶC ĐIỂM LÂM SÀNG, HÌNH ẢNH NÃO VÀ KẾT QUẢ ĐIỀU TRỊ HỖ TRỢ CỦA CEREBROLYSIN TRÊN BỆNH NHÂN NHỒI MÁU NÃO CẤP

Abstract

Background: Acute ischemic stroke is the most common subtype of stroke and a leading cause of long-term neurological disability. Identifying clinical and neuroimaging characteristics associated with treatment outcomes is essential for prognosis and patient management. Objective: To describe the clinical characteristics, neuroimaging features, and to analyze factors associated with treatment outcomes in patients with acute ischemic stroke. Materials and methods: A nonrandomized controlled clinical intervention study was conducted on 140 patients diagnosed with acute ischemic stroke according to the World Health Organization (WHO) criteria and treated at Can Tho Central General Hospital from June 2024 to March 2026. Clinical characteristics, neuroimaging findings, and treatment outcomes were evaluated and analyzed after 30 days of follow-up. Results: The mean age of the patients was 63.61 ± 11.5 years, and 68.6% were aged ≥60 years. The most common clinical manifestations were hemiparesis/hemiplegia (97.9%), dysarthria (90.7%), and central facial palsy (82.9%). Most patients had a moderate stroke severity according to the National Institutes of Health Stroke Scale (NIHSS) (92.1%). Lesions were predominantly located within the middle cerebral artery territory (70.7%), most commonly involving the cerebral hemisphere (57.9%). The improvement rate was significantly higher in the Cerebrolysin group than in the control group (92.9% vs. 54.3%, OR = 10.95, 95% CI: 3.93–30.48; p < 0.001). The rates of hemorrhagic transformation and adverse events were higher in the Cerebrolysin group than in the control group (4.3% vs. 1.4%); however, the differences were not statistically significant (p > 0.05). Conclusions: After 30 days of follow-up, both the Cerebrolysin and control groups demonstrated significant improvements in NIHSS and modified Rankin Scale (mRS) scores.