PREVALENCE OF SARCOPENIA AND ASSOCIATED FACTORS IN NON-DIALYSIS CHRONIC KIDNEY DISEASE PATIENTS
Main Article Content
Abstract
Background: Sarcopenia is a prevalent complication among non-dialysis chronic kidney disease patients, tending to deteriorate with disease progression, thereby increasing mortality risk and impairing quality of life. Objectives: To determine the prevalence and factors associated with sarcopenia in non-dialysis chronic kidney disease patients. Materials and methods: A crosssectional descriptive study was conducted on 84 patients with chronic kidney disease not yet on regular dialysis at Can Tho University of Medicine and Pharmacy Hospital during the period 2024– 2026. Characteristics related to sarcopenia and chronic kidney disease were analyzed to determine the prevalence of sarcopenia and factors associated with sarcopenia in chronic kidney disease patients. Data were processed using SPSS Statistics 27, with p < 0.05 considered statistically significant. Results: The prevalence of sarcopenia was 35.7%, of which 9.5% had severe sarcopenia. The prevalence of sarcopenia across CKD stages 3a, 3b, 4, and 5 was 28.6%, 44.4%, 66.7%, and 75.0%, respectively (p < 0.001). CKD stage, BMI, and sex were independent factors associated with sarcopenia. Conclusion: The prevalence of sarcopenia was 35.7%. CKD stage, BMI, and sex were independently associated with sarcopenia after adjustment. Screening for sarcopenia should be performed in CKD patients, particularly in those with advanced stages.
Keywords
Chronic kidney disease, sarcopenia, non-dialysis patients
Article Details
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References
2. Stevens PE, Ahmed SB, Carrero JJ, Foster B, Francis A, et al. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International. 2024. 105(4), S117-S314, https://doi.org/10.1016/j.kint.2023.10.018.
3. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing. 2019. 48(1), 16-31, https://doi.org/10.1093/ageing/afy169.
4. Souza VA, Oliveira D, Barbosa SR, Corrêa JOA, Colugnati FAB, et al. Sarcopenia in patients with chronic kidney disease not yet on dialysis: analysis of the prevalence and associated factors. PLOS ONE. 2017. 12(4), e0176230, https://doi.org/10.1371/journal.pone.0176230.
5. de Amorim GJ, Calado CKM, Souza de Oliveira BC, Araujo RPO, Filgueira TO, et al. Sarcopenia in non-dialysis chronic kidney disease patients: Prevalence and associated factors. Frontiers in Medicine. 2022. 9, 854410, https://doi.org/10.3389/fmed.2022.854410.
6. Nguyễn Bá Ngọc Sơn, Đặng Thị Việt Hà, Phạm Hoài Thu. Sarcopenia và một số yếu tố liên quan ở người bệnh thận mạn chưa điều trị thay thế thận. Tạp chí Y học Việt Nam. 2024. 534(2), https://doi.org/10.51298/vmj.v534i2.8159.
7. Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, et al. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. Journal of the American Medical Directors Association. 2020. 21(3), 300-307.e2, https://doi.org/10.1016/j.jamda.2019.12.012.
8. St-Onge MP, Wang Z, Horlick M, Wang J, Heymsfield SB. Dual-energy X-ray absorptiometry lean soft tissue hydration: independent contributions of intra- and extracellular water. American Journal of Physiology-Endocrinology and Metabolism. 2004. 287(5), E842-E847, https://doi.org/10.1152/ajpendo.00361.2003.
9. Aiello F, Dueñas EP, Musso CG. Senescent nephropathy: the new renal syndrome. Healthcare. 2017. 5(4), 81, https://doi.org/10.3390/healthcare5040081.
10. Chu Thị Ngọc Hà, Nguyễn Ngọc Tâm, Đỗ Gia Tuyển, Đặng Thị Việt Hà, Nguyễn Hữu Dũng. Thực trạng bệnh thận mạn tính ở người cao tuổi tại Bệnh viện Bạch Mai. Tạp chí Y học Việt Nam. 2023. 532(2), https://doi.org/10.51298/vmj.v532i2.7638.
11. Nguyễn Lê Thanh Trúc, Đỗ Nhật Phương, Huỳnh Thị Hồng Nhung, Ngô Nguyễn Tường Vi, Hồ Thị Anh Thư. Tình trạng suy dinh dưỡng và một số yếu tố liên quan ở người bệnh thận mạn đang điều trị nội trú tại Khoa Nội Tổng hợp Bệnh viện Đa khoa tỉnh Trà Vinh. Tạp chí Y học Việt Nam. 2024. 540(1), https://doi.org/10.51298/vmj.v540i1.10262.
12. Zhang X, Bansal N, Go AS, Hsu CY. Gastrointestinal symptoms, inflammation and hypoalbuminemia in chronic kidney disease patients: A cross-sectional study. BMC Nephrology. 2015. 16, 211, https://doi.org/10.1186/s12882-015-0209-z.
13. Thang LV, Nguyen TK, Nguyen VH, Truong QK, Nguyen HD, et al. Serum total iron-binding capacity and iron status in patients with non-dialysis-dependent chronic kidney disease: a crosssectional study in Vietnam. Asia Pacific Journal of Clinical Nutrition. 2020. 29(1), 48-54, https://doi.org/10.6133/apjcn.202003_29(1).0007.
14. Oh KH, Park SK, Park HC, Chin HJ, Chae DW, et al. KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease): design and methods. BMC Nephrology. 2014. 15, 80, https://doi.org/10.1186/1471-2369-15-80.
15. Jin K, Li X, Ma Y, Yang D, Tan X, et al. Risk Factors Associated With Sarcopenia in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Journal of Cachexia, Sarcopenia and Muscle. 2026. 17(1), e70166, https://doi.org/10.1002/jcsm.70166.
16. Kruse NT, Buzkova P, Barzilay JI, Valderrabano RJ, Robbins JA, et al. Association of skeletal muscle mass, kidney disease and mortality in older men and women: the cardiovascular health study. Aging. 2020. 12(21), 21023-21036, https://doi.org/10.18632/aging.202135.