ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ MỘT SỐ YẾU TỐ LIÊN QUAN BỆNH NHÂN UNG THƯ VÚ TÁI PHÁT, DI CĂN CÓ THỤ THỂ NỘI TIẾT DƯƠNG TÍNH

Abstract

Background: Breast cancer is the most common malignancy and one of the leading causes of cancer-related mortality among women worldwide. Approximately 70–80% of cases are hormone receptor–positive, and endocrine therapy remains the cornerstone of treatment for recurrent and metastatic hormone receptor–positive breast cancer. Objectives: To describe the clinical and paraclinical features and identify selected associated factors in patients with recurrent and metastatic hormone receptor–positive breast cancer. Materials and methods: A case series of 22 patients diagnosed  with recurrent and metastatic hormone receptor–positive breast cancer at Can Tho Oncology Hospital from July 2024 to January 2026. Results: The mean age was 51.86 ± 10.80 years, with the majority of patients aged <60 years (77.3%). A family history of breast cancer was reported in 18.2% of patients. The most common reasons for admission were breast mass (40.9%), pain (36.4%), and dyspnea (22.7%). Most patients had elevated CA 15 – 3 levels (95.5%). The Ki-67 index >15% was observed in 90.9% of cases. Patients aged < 60 years had a higher rate of visceral metastasis than those aged ≥ 60 years (88.2% vs. 20.0%), with a statistically significant association (OR = 10.67, 95% CI: 1.472–77.277; p = 0.009). Conclusions: Most patients with recurrent and metastatic hormone receptor–positive breast cancer had elevated CA 15 – 3 levels, suggesting high tumor biological activity, and age under 60  years may be associated with an increased risk of visceral metastasis.