STUDY ON TREATMENT OUTCOMES AND PROGNOSTIC VALUE OF SII AND PLR IN PATIENTS WITH ACUTE PANCREATITIS
Main Article Content
Abstract
Background: Acute pancreatitis (AP) is a common medical emergency, with approximately 20% of cases progressing to severe disease and associated with high mortality. Systemic inflammatory markers such as the Systemic Immune-Inflammation Index (SII) and Platelet-toLymphocyte Ratio (PLR) have been studied for early prediction of disease severity and mortality. Objectives: To evaluate the treatment outcomes of AP and determine the prognostic value of SII and PLR for disease severity. Materials and methods: A cross-sectional descriptive study with an analysis of 120 patients diagnosed with AP admitted to Can Tho Central General Hospital from June 2024 to November 2025. Data were analyzed using SPSS 27 software, utilizing ROC curves to determine prognostic value. Results: Male patients accounted for 63.3%, and the age group ≤ 55 accounted for 65%. The rate of severe AP was 27.5%. The median SII and PLR values in the severe AP group were significantly higher than in the non-severe group (p < 0.05). At a cut-off of SII ≥ 2767 (AUC 0.71) and PLR ≥ 216 (AUC 0.66), both indices were valuable for predicting severity; notably, SII, especially when combined with PLR, showed superior predictive value. Regarding treatment outcomes, 84.2% of patients recovered and were discharged, while the rate of mortality or discharge against medical advice due to severe condition was 15.8%. The treatment failure group had significantly higher SII and PLR indices compared to the successful treatment group (p<0.05). Conclusions: SII and PLR are valuable markers for predicting severity and treatment outcomes in patients with acute pancreatitis. SII, particularly when combined with PLR, demonstrates superior prognostic capability.
Keywords
Acute pancreatitis, SII, PLR, severity prediction, treatment outcomes
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