AN EVALUATION OF HYPOALBUMINEMIA AND IRON DEFICIENCY ANEMIA IN CHILDREN AGED FROM 2 MONTHS TO UNDER 5 YEARS OLD WITH PNEUMONIA

Tran Thi Nhu Y1, Ly Quoc Trung2, Nguyen Hong Ngan3, Le Thi Nhan Duyen3, To Thi Yen Nhi3, Trinh Ngoc Khoa3, Ha Thi Thao Mai3,
1 Ca Mau Obstetrics and Pediatrics Hospital
2 Soc Trang Community College
3 Can Tho University of Medicine and Pharmacy

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Tóm tắt

Background: Pneumonia is a potentially fatal disease that greatly compromises the health of children. Utilizing laboratory tests is extremely beneficial in the diagnosis, monitoring, and prognosis determination of the condition. In the realm of pediatric pneumonia, effective diagnostic procedures include assessments for albumin levels and iron deficiency anemia. Objectives: (1) Determine the proportions of hypoalbuminemia and iron deficiency anemia in children aged from 2 months to under 5 years old with pneumonia at Ca Mau Obstetrics and Pediatrics Hospital in 2022-2023 (2) Evaluate the association between hypoalbuminemia, iron deficiency anemia and pneumonia in children aged from 2 months to under 5 years old at Ca Mau Obstetrics and Pediatrics Hospital in 2022-2023. Materials and methods: a cross-sectional descriptive study on 177 pediatric patients from 2 months to under 5 years old who were diagnosed with pneumonia and received inpatient treatment at Ca Mau Obstetrics and Pediatrics Hospital during the research period. Results: The percentage of patients aged 2 months to 2 years was 59.9%, which was more than the percentage of patients aged 2 years to 5 years, which was 40.1%. The average age was 22.5±15.82 months old. The male patients constituted 56.5% of the total, whilst the female patients with pneumonia accounted for 43.5%. Children with pneumonia made  up 88.1% of the patient population; children with severe pneumonia made up 11.9% of the patient population. The average albumin concentration was 38.47±2.39g/L. The proportion of hypoalbuminemia was 26% and the proportion of iron deficiency anemia was 41.8%. Children with iron deficiency anemia had a higher rate of severe pneumonia (20.3%) than those without (5.8%). Compared to 2.9% of children without iron deficiency anemia, 12.2% of those with the condition required more than two antibiotics to treat pneumonia. Conclusion: When hypoalbuminemia is present, the severity of pneumonia is significantly increased. Inadequate iron levels cause anemia, which worsens pediatric pneumonia and necessitates supplementary antibiotic therapy.

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Tài liệu tham khảo

1. Solomon Y, Kofole Z, Fantaye T, Ejigu S. Prevalence of pneumonia and its determinant factors among under-five children in Gamo Zone, southern Ethiopia, 2021. Front Pediatr.
2022;10:1017386. Published 2022 Dec 22. doi:10.3389/fped.2022.1017386
2. Soeters PB, Wolfe RR, Shenkin A. Hypoalbuminemia: Pathogenesis and Clinical Significance. JPEN J Parenter Enteral Nutr. 2019;43(2):181-193. doi:10.1002/jpen.1451.
3. Chen L, Miao C, Chen Y, et al. Age-specific risk factors of severe pneumonia among pediatric patients hospitalized with community-acquired pneumonia. Ital J Pediatr. 2021;47(1):100. Published 2021 Apr 23. doi:10.1186/s13052-021-01042-3.
4. Hiroyuki Miyazaki. Comprehensive analysis of prognostic factors in hospitalized patients with pneumonia occurring outside the hospital: serum albumin is not less important than pneumonia severity assessment scale, J Journal of infection chemotherapy, 2018;24(8):602-609.
5. Chisti MJ, Kawser CA, Rahman ASMMH, et al. Prevalence and outcome of anemia among children hospitalized for pneumonia and their risk of mortality in a developing country. Sci Rep. 2022;12(1):10741. Published 2022 Jun 24. doi:10.1038/s41598-022-14818-2.
6. Revised WHO Classification and Treatment of Pneumonia in Children at Health Facilities: Evidence Summaries. Geneva: World Health Organization; 2014. Available from: https://www.ncbi.nlm.nih.gov/books/NBK264162/.
7. María Elena Álvarez Andrade et al. Hipoalbuminemia en niños con neumonía grave adquirida en la comunidad, Revista Cubana de Medicina Intensiva y Emergencias. 2019;18(3): e594.
8. Nguyen Thi Hong Nhan, Nguyen Van Long. The relationship between iron deficiency anemia and pneumonia in children under 5 years old examined and treated at Saint Paul General Hospital in 2017, Journal of Pediatrics Research and Practice. 2019; 2:37-47.
9. Nguyen Duc Tri, Nguyen Minh Phuong. Vitamin D deficiency in children with pneumonia from 2 months to 5 years old at Can Tho City Children's Hospital, 2019-2020. CJUMP. 2023;(30):145152. https://tapchi.ctump.edu.vn/index.php/ctump/article/view/1554.
10. Nguyen Thi Ha et al. Clinical characteristics and bacterial etiology of community-acquired pneumonia in children at the International Department of National Children's Hospital, Journal of Medical Research. 2020;131(7):67-73.
11. Otal Y, Avcıoglu G, Haydar FG. A new biomarker in severe pneumonia associated with coronavirus disease 2019: hypoalbuminemia. A prospective study. Sao Paulo Med J. 2022;140(3):378-383. doi:10.1590/1516-3180.2021.0066.R2.16082021.
12. Nguyen Dinh Chung. Nutritional status and iron deficiency anemia in children with pneumonia from 1-24 months old at the National Children's Hospital. Thesis. 2019. Hanoi Medical University.
13. Lee JH, Kim J, Kim K, et al. Albumin and C-reactive protein have prognostic significance in patients with community-acquired pneumonia. J Crit Care. 2011;26(3):287-294. doi:10.1016/j.jcrc.2010.10.007.
14. P M, Awasthi S. Predicting Complicated Parapneumonic Effusion in Community Acquired Pneumonia: Hospital Based Case-Control Study. Indian J Pediatr. 2019;86(2):140-147. doi:10.1007/s12098-018-2769-y.
15. Chang IF, Shih WL, Liu YC, et al. The association of anemia with the clinical outcomes of community-acquired pneumonia in children. Pediatr Pulmonol. 2022;57(6):1416-1424. doi:10.1002/ppul.25892.