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Ngày xuất bản:
25/07/2024
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25/07/2024
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Ngô, H. T., & Trần, K. S. (2024). VAI TRÒ CỦA ĐA HÌNH MICRORNA-146A TRONG TIÊN LƯỢNG NHỒI MÁU CƠ TIM CẤP. Tạp chí Y Dược học Cần Thơ, 76, 224-232. https://doi.org/10.58490/ctump.2024i76.2812
VAI TRÒ CỦA ĐA HÌNH MICRORNA-146A TRONG TIÊN LƯỢNG NHỒI MÁU CƠ TIM CẤP
Nội dung chính của bài viết
Tóm tắt
Nhồi máu cơ tim cấp là một bệnh lý nguy hiểm với tỷ lệ tử vong cao, bệnh nhân sống sót sau nhồi máu cơ tim vẫn phải chịu những hậu quả nặng nề từ các biến cố tim mạch. Do đó, việc tiên lượng sớm và chuẩn xác các đối tượng nguy cơ cao là việc làm hết sức quan trọng. Hiện nay, dựa trên việc cá thể hóa người bệnh đã hướng đến một cách tiếp cận mới trong tiên lượng dựa trên khảo sát các đặc điểm đa hình gen của từng bệnh nhân, qua đó cung cấp nhiều thông tin quan trọng trong tiên lượng bệnh. Gần đây, một đa hình của microRNA-146a là rs2910164 (G/C) được phát hiện có khả năng tiên lượng biến cố tim mạch chính ở bệnh nhân nhồi máu cơ tim cấp, qua đó mở ra hướng tiếp cận mới của các đa hình miRNA trong tiên lượng bệnh ngay từ cấp độ phân tử.
Chi tiết bài viết
Từ khóa
nhồi máu cơ tim cấp, microRNA-146a, đa hình gen, tiên lượng
Tài liệu tham khảo
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11. Tang Y, Luo X, Cui H, Ni X, Yuan M et al. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum. 2009. 60(4), 1065-1075, doi: 10.1002/art.24436.
12. Li X, Liao J, Su X, Li W, Bi Z et al. Human urine-derived stem cells protect against renal ischemia/reperfusion injury in a rat model via exosomal miR-146a-5p which targets IRAK1. Theranostics. 2020. 10(21), 9561, doi: 10.7150/thno.42153.
13. Wang XP, Luoreng ZM, Zan LS, Li F, Li N. Bovine miR-146a regulates inflammatory cytokines of bovine mammary epithelial cells via targeting the TRAF6 gene. Journal of Dairy Science. 2017. 100(9), 7648-7658, doi: 10.3168/jds.2017-12630.
14. Zhang X, Guo Y, Xu X, Tang T, Sun L et al. miR-146a promotes Borna disease virus 1 replication through IRAK1/TRAF6/NF-κB signaling pathway. Virus research. 2019. 271(1), 197671, doi: 10.1016/j.virusres.2019.197671.
15. Quinn EM, Wang JH. MicroRNA-146a is upregulated by and negatively regulates TLR2 signaling. PLoS One. 2013. 8(4), e62232, doi: 10.1371/journal.pone.0062232..
16. Yang L, Boldin MP, Yu Y, Liu CS, Ea CK et al. miR-146a controls the resolution of T cell responses in mice. J Exp Med. 2012. 209(9),1655-70, doi: 10.1084/jem.20112218.
17. Hsu YR, Chang SW, Lin YC, Yang CH. MicroRNA-146a Alleviates Experimental Autoimmune Anterior Uveitis in the Eyes of Lewis Rats. Mediators Inflamm. 2017, 9601349, doi: 10.1155/2017/9601349.
18. He X, Tang R. MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis. EBioMedicine. 2016. 13(1), 339-47, doi: 10.1016/j.ebiom.2016.10.024.
19. Lu LF, Boldin MP, Chaudhry A, Lin LL, Taganov KD et al. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 2010. 142(6), 914-29, doi: 10.1016/j.cell.2010.08.012.
20. Chen Y, Wang JJ, Li J, Hosoya KI, Ratan R et al. Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes. Diabetologia. 2012. 55(9), 2533-45, doi: 10.1007/s00125-012-2594-1.
21. Shirai T, Nazarewicz RR. The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease. Journal of Experimental Medicine. 2016. 213(3), 33754, doi: 10.1084/jem.20150900.
22. Ye EA, Steinle JJ. miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high glucose conditions. Vision Res. 2017. 139(1),15-22, doi: 10.1016/j.visres.2017.03.009.
23. Guo H, Zhang Y, Liao Z, Zhan W, Wang Y et al. MiR-146a upregulates FOXP3 and suppresses inflammation by targeting HIPK3/STAT3 in allergic conjunctivitis. Ann Transl Med. 2022. 10(6), 344, doi: 10.21037/atm-22-982.
24. Ferrer-Marín F. miR-146a rs2431697 identifies myeloproliferative neoplasm patients with higher secondary myelofibrosis progression risk. Leukemia. 2020. 34(10), 2648-2659, doi:
10.1038/s41375-020-0767-3.
25. Li T, Li M. miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6. Oncol Rep. 2019. 41(5), 2897-2908. doi: 10.3892/or.2019.7046.
26. Morishita Y, Imai T, Yoshizawa H, Watanabe M, Ishibashi K et al. Delivery of microRNA-146a with polyethylenimine nanoparticles inhibits renal fibrosis in vivo. Int J Nanomedicine. 2015. 10(1), 3475-88, doi: 10.2147/IJN.S82587.
27. Zou Y, Cai Y, Lu D, Zhou Y, Yao Q et al. MicroRNA-146a-5p attenuates liver fibrosis by suppressing profibrogenic effects of TGFβ1 and lipopolysaccharide. Cell Signal. 2017. 39(1), 1-8, doi: 10.1016/j.cellsig.2017.07.016.
28. Raitoharju E. miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study. Atherosclerosis. 2011. 219(1), 211-7, doi: 10.1016/j.atherosclerosis.2011.07.020.
29. Takahashi Y, Satoh M, Minami Y, Tabuchi T, Itoh T et al. Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of reninangiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels. Clin Sci. 2010. 119(9), 395-405, doi: 10.1042/CS20100003.
30. Oerlemans MI, Mosterd A, Dekker MS, de Vrey EA, van Mil A et al. Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs. EMBO Mol Med. 2012. 4(11), 1176-85, doi: 10.1002/emmm.201201749.
31. Xiao S, Xue T, Pan Q, Hu Y, Wu Q et al. MicroRNA-146a Serves as a Biomarker for Adverse Prognosis of ST-Segment Elevation Myocardial Infarction. Cardiovasc Ther. 2021, 2923441, doi: 10.1155/2021/2923441.
32. Al-Koofee DA, Mubarak SM. Genetic polymorphisms. The Recent Topics in Genetic Polymorphisms. 2019, doi: 10.5772/intechopen.88063.
33. Bao MH, Xiao Y, Zhang QS, Luo HQ, Luo J et al. Meta-Analysis of miR-146a Polymorphisms Association with Coronary Artery Diseases and Ischemic Stroke. Int J Mol Sci. 2015. 16(7), 14305-17, doi: 10.3390/ijms160714305.
34. Qiao XR, Zheng T, Xie Y, Yao X, Yuan Z et al. MiR-146a rs2910164 (G/C) polymorphism is associated with the development and prognosis of acute coronary syndromes: an observational study including case control and validation cohort. J Transl Med. 2023. 21(1), 325, doi: 10.1186/s12967-023-04140-4.
35. Tongneng X. Correlation of miRNA-146a SNP and its expression with the diagnosis and prognosis of patients with acute STEMI. J Clin Cardiol. 2021. 37(11), 1002-1007, doi: 10.13201/j.issn.1001-1439.2021.11.007.
36. Shi B, Wang X, Xue T, Liu J, Wu W et al. Expression level of miR-146a correlates with the coronary lesion severity and clinical prognosis in UA patients. Research square. 2023, doi: 10.21203/rs.3.rs-3140515/v1.
37. Huang S. A Genetic Variant in Pre-miR-146a (rs2910164 C>G) Is Associated with the Decreased Risk of Acute Coronary Syndrome in a Chinese Population. Tohoku J Exp Med. 2015. 237(3), 227-33, doi: 10.1620/tjem.237.227.
2. Leitão AL, Enguita FJ. A Structural View of miRNA Biogenesis and Function. Noncoding RNA. 2022. 8(1), 1-10, doi: 10.3390/ncrna8010010.
3. Çakmak HA, Demir M. MicroRNA and Cardiovascular Diseases. Balkan Med Journal. 2020.
37(2), 60-71, doi: 10.4274/balkanmedj.galenos.2020.2020.1.94.
4. Yang Z, Liu Z. The emerging role of microRNAs in breast cancer. Journal of Oncology. 2020.
(1), doi: 10.1155.2020.9160905.
5. Lu TX, Rothenberg ME. MicroRNA. Journal of allergy and clinical immunology. 2018. 141(4), 1202-1207, doi: 10.1016/j.jaci.2017.08.034.
6. Nitschke L, Tewari A, Coffin SL, Xhako E, Pang K et al. miR760 regulates ATXN1 levels via interaction with its 5' untranslated region. Genes & Development. 2020. 34(17-18), 1147-1160, doi: 10.1101/gad.339317.120.
7. O'Brien J. Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation. Frontiers in endocrinology. 2018. 9(1), 402, doi: 10.3389/fendo.2018.00402.
8. Liao Z, Zheng R, Shao G. Mechanisms and application strategies of miRNA‑146a regulating inflammation and fibrosis at molecular and cellular levels. International journal of molecular medicine. 2023. 51(1), 1-16, doi: 10.3892/ijmm.2022.5210.
9. Paterson MR, Kriegel AJ. MiR-146a/b: a family with shared seeds and different roots. Physiol Genomics. 2017. 49(4), 243-252, doi: 10.1152/physiolgenomics.00133.2016.
10. He L, Wang Z, Zhou R, Xiong W, Yang Y et al. Dexmedetomidine exerts cardioprotective effect through miR-146a-3p targeting IRAK1 and TRAF6 via inhibition of the NF-κB pathway. Biomedicine & Pharmacotherapy. 2021. 133(1), 110993, doi: 10.1016/j.biopha.2020.110993.
11. Tang Y, Luo X, Cui H, Ni X, Yuan M et al. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum. 2009. 60(4), 1065-1075, doi: 10.1002/art.24436.
12. Li X, Liao J, Su X, Li W, Bi Z et al. Human urine-derived stem cells protect against renal ischemia/reperfusion injury in a rat model via exosomal miR-146a-5p which targets IRAK1. Theranostics. 2020. 10(21), 9561, doi: 10.7150/thno.42153.
13. Wang XP, Luoreng ZM, Zan LS, Li F, Li N. Bovine miR-146a regulates inflammatory cytokines of bovine mammary epithelial cells via targeting the TRAF6 gene. Journal of Dairy Science. 2017. 100(9), 7648-7658, doi: 10.3168/jds.2017-12630.
14. Zhang X, Guo Y, Xu X, Tang T, Sun L et al. miR-146a promotes Borna disease virus 1 replication through IRAK1/TRAF6/NF-κB signaling pathway. Virus research. 2019. 271(1), 197671, doi: 10.1016/j.virusres.2019.197671.
15. Quinn EM, Wang JH. MicroRNA-146a is upregulated by and negatively regulates TLR2 signaling. PLoS One. 2013. 8(4), e62232, doi: 10.1371/journal.pone.0062232..
16. Yang L, Boldin MP, Yu Y, Liu CS, Ea CK et al. miR-146a controls the resolution of T cell responses in mice. J Exp Med. 2012. 209(9),1655-70, doi: 10.1084/jem.20112218.
17. Hsu YR, Chang SW, Lin YC, Yang CH. MicroRNA-146a Alleviates Experimental Autoimmune Anterior Uveitis in the Eyes of Lewis Rats. Mediators Inflamm. 2017, 9601349, doi: 10.1155/2017/9601349.
18. He X, Tang R. MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis. EBioMedicine. 2016. 13(1), 339-47, doi: 10.1016/j.ebiom.2016.10.024.
19. Lu LF, Boldin MP, Chaudhry A, Lin LL, Taganov KD et al. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 2010. 142(6), 914-29, doi: 10.1016/j.cell.2010.08.012.
20. Chen Y, Wang JJ, Li J, Hosoya KI, Ratan R et al. Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes. Diabetologia. 2012. 55(9), 2533-45, doi: 10.1007/s00125-012-2594-1.
21. Shirai T, Nazarewicz RR. The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease. Journal of Experimental Medicine. 2016. 213(3), 33754, doi: 10.1084/jem.20150900.
22. Ye EA, Steinle JJ. miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high glucose conditions. Vision Res. 2017. 139(1),15-22, doi: 10.1016/j.visres.2017.03.009.
23. Guo H, Zhang Y, Liao Z, Zhan W, Wang Y et al. MiR-146a upregulates FOXP3 and suppresses inflammation by targeting HIPK3/STAT3 in allergic conjunctivitis. Ann Transl Med. 2022. 10(6), 344, doi: 10.21037/atm-22-982.
24. Ferrer-Marín F. miR-146a rs2431697 identifies myeloproliferative neoplasm patients with higher secondary myelofibrosis progression risk. Leukemia. 2020. 34(10), 2648-2659, doi:
10.1038/s41375-020-0767-3.
25. Li T, Li M. miR‑146a regulates the function of Th17 cell differentiation to modulate cervical cancer cell growth and apoptosis through NF‑κB signaling by targeting TRAF6. Oncol Rep. 2019. 41(5), 2897-2908. doi: 10.3892/or.2019.7046.
26. Morishita Y, Imai T, Yoshizawa H, Watanabe M, Ishibashi K et al. Delivery of microRNA-146a with polyethylenimine nanoparticles inhibits renal fibrosis in vivo. Int J Nanomedicine. 2015. 10(1), 3475-88, doi: 10.2147/IJN.S82587.
27. Zou Y, Cai Y, Lu D, Zhou Y, Yao Q et al. MicroRNA-146a-5p attenuates liver fibrosis by suppressing profibrogenic effects of TGFβ1 and lipopolysaccharide. Cell Signal. 2017. 39(1), 1-8, doi: 10.1016/j.cellsig.2017.07.016.
28. Raitoharju E. miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study. Atherosclerosis. 2011. 219(1), 211-7, doi: 10.1016/j.atherosclerosis.2011.07.020.
29. Takahashi Y, Satoh M, Minami Y, Tabuchi T, Itoh T et al. Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of reninangiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels. Clin Sci. 2010. 119(9), 395-405, doi: 10.1042/CS20100003.
30. Oerlemans MI, Mosterd A, Dekker MS, de Vrey EA, van Mil A et al. Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs. EMBO Mol Med. 2012. 4(11), 1176-85, doi: 10.1002/emmm.201201749.
31. Xiao S, Xue T, Pan Q, Hu Y, Wu Q et al. MicroRNA-146a Serves as a Biomarker for Adverse Prognosis of ST-Segment Elevation Myocardial Infarction. Cardiovasc Ther. 2021, 2923441, doi: 10.1155/2021/2923441.
32. Al-Koofee DA, Mubarak SM. Genetic polymorphisms. The Recent Topics in Genetic Polymorphisms. 2019, doi: 10.5772/intechopen.88063.
33. Bao MH, Xiao Y, Zhang QS, Luo HQ, Luo J et al. Meta-Analysis of miR-146a Polymorphisms Association with Coronary Artery Diseases and Ischemic Stroke. Int J Mol Sci. 2015. 16(7), 14305-17, doi: 10.3390/ijms160714305.
34. Qiao XR, Zheng T, Xie Y, Yao X, Yuan Z et al. MiR-146a rs2910164 (G/C) polymorphism is associated with the development and prognosis of acute coronary syndromes: an observational study including case control and validation cohort. J Transl Med. 2023. 21(1), 325, doi: 10.1186/s12967-023-04140-4.
35. Tongneng X. Correlation of miRNA-146a SNP and its expression with the diagnosis and prognosis of patients with acute STEMI. J Clin Cardiol. 2021. 37(11), 1002-1007, doi: 10.13201/j.issn.1001-1439.2021.11.007.
36. Shi B, Wang X, Xue T, Liu J, Wu W et al. Expression level of miR-146a correlates with the coronary lesion severity and clinical prognosis in UA patients. Research square. 2023, doi: 10.21203/rs.3.rs-3140515/v1.
37. Huang S. A Genetic Variant in Pre-miR-146a (rs2910164 C>G) Is Associated with the Decreased Risk of Acute Coronary Syndrome in a Chinese Population. Tohoku J Exp Med. 2015. 237(3), 227-33, doi: 10.1620/tjem.237.227.