THE CLINICAL, LABORATORY CHARACTERISTICS, THE VALUE OF LEUKOCYTES, PLATELETS, C REACTIVE PROTEIN IN THE PROGNOSIS OF NEONATAL SEPSIS MORTALITY
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Abstract
Background: Despite advances in diagnosis and treatment, neonatal sepsis is a severe systemic illness with the highest mortality rate in the country. Objectives: to describe the clinical and laboratory characteristics and the value of leukocytes, platelets, C reactive protein in the prognosis of neonatal sepsis mortality. Materials and methods: A cross-sectional descriptive study with analysis on 62 children aged 0-28 days with sepsis at Can Tho Children’s Hospital. Results: The score of male/female was (1.95/1), early neonatal sepsis was common with a rate of 53.2%. Common clinical symptoms are tachypnea (62.9%), chest indrawing (58.1%), fever (56.5%), jaundice (46.8%), abdominal distension (41.9%) and poor suckling (33.9%). Blood culture results showed that Gram positive bacteria accounted for a high rate of 58%, Staphylococus accounted for 54.8%. aPTT was prolonged (60.02 ± 28.72s), pH and alkaline deficiency were lower than normal with values (7.23 ± 0.15 and -12.03 ± 7.23, respectively). The values of BC, CRP did not have significant predictive significance for mortality. Decreased TC accounted for 16.1%, decreased TC increased the risk of death by 12 times (p = 0.002). TC <150x103/mm3 means pretty good in quantization with AUC: 0.731 (p = 0.028). The simultaneous combination of BC (>20x103/mm3) and TC (<150x103/mm3) yielded an increase to 0.770 (p = 0.01). Conlusion: TC <150x103/mm3, the combination of BC (>20x103/mm3) and TC (<150x103/mm3) at the time of clinical suspicion of sepsis has a fairly good significance in the prognosis of neonatal sepsis mortality.
Keywords
sepsis, neonates
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