ANTIBODY SCREENING AND IDENTIFICATION OF UNEXPECTED RED CELL ANTIBODIES AND RELATED FACTORS IN PATIENTS WITH CHRONIC ANEMIA WITH INDICATION BLOOD TRANSFUSIONS IN 2018-2019
Main Article Content
Abstract
Background: Antibody screening and identification of unexpected red cell antibodies are important in pre-transfusion testing in reducing the incidence of complications caused by abnormal antibodies produced by incompatible blood transfusion. Objectives: 1) Determine the rate and characteristics of unexpected red cell antibodies; 2) Investigate some factors related to the occurrence of unexpected red cell antibodies in patients with chronic anemia indicated for blood transfusion. Materials and methods: A cross-sectional study on 577 chronic anemia patients with blood transfusion indication in Bac Lieu and Can Tho in 2019-2020. Results: Irregular antibodies were detected in decreasing rate include anti-E accounting for 2.3%, anti-Mia accounting for 1.0%, anti-c accounting for 0.5% and other unexpected antibodies accounting for less than 0.5%. The Rh blood group had 2 unexpected antibodies that were recognized as anti-E and anti-c. There was a significant difference in antibody occurrence among patients with blood transfusion of 5 or more times compared with group of patients with blood transfusion from 1 to 4 times. Conclusion: There are occurrence of irregular antibodies in patients with chronic anemia receiving blood transfusion. The more blood transfusions, the higher the rate of unexpected antibodies occurring.
Keywords
Unexpected irregular antibodies, antibody screening and identification, red blood cells transfusion, chronic anemia
Article Details
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References
2. Vũ Đức Bình (2017), Nghiên cứu phát hiện kháng thể bất thường bằng bộ panel hồng cầu của Viện Huyết học - Truyền máu TW để đảm bảo truyền máu có hiệu lực, Luận án Tiến sỹ Y học, Đại học Y Hà Nội.
3. Bộ Y tế (2015), Hướng dẫn chẩn đoán và điều trị một số bệnh lý huyết học (Ban hành kèm theo Quyết định số 1494/QĐ-BYT ngày 22/4/2015 của Bộ trưởng Bộ Y tế).
4. Nguyễn Thị Tuyết Trâm, Nguyễn Duy Thăng, Trần Văn Lượng, Hà Thúc Thuận, Phan Quang Hoàng Minh, Lê Thanh Hải (2013), Khảo sát kháng thể bất thường kháng hồng cầu bằng phản ứng hòa hợp tại khoa huyết học lâm sàng bệnh viện Trung ương Huế, Y học TP. Hồ Chí Minh. Số 05/2013, tr. 58-63.
5. Phạm Quang Vinh (2013), Hệ thống nhóm máu và ứng dụng trong truyền máu, Huyết học – Truyền máu cơ bản, Tài liệu đào tạo cử nhân kỹ thuật y học, NXB Y học.
6. Healsmith, S., Savoia, H., and Kane, S. C. (2019), How clinically important are non-D Rh antibodies?, Acta Obstet Gynecol Scand. 98(7), pp. 877-884.
7. Ko, K. H., et al. (2012), Frequency of unexpected antibody and consideration during transfusion, Korean J Anesthesiol. 62(5), pp. 412-7.
8. Nance S.T. (2010), Management of alloimmnized patients, ISBT Science Series, Vol. 5, pp. 274-278.
9. Norgaard, A., Gybel-Brask, M., Rieneck, K., Christensen, BK, El-Ghina, RZ, Johansson, PI, & Dziegiel, MH (2016), Managing the bleeding emergency in a patient with red cell antibodies, ISBT Science Series, Vol. 11. pp. 44-53.
10. Pirenne, F., & Vingert, B. (2016), Mechanisms underlying red-cell alloimmunization in sickle-cell disease, ISBT Science Series. 11, pp. 292-296.
11. Thornton, Nicole (2015), Serological tools for investigating immunohaematology problems, ISBT Science Series. 10, pp. 26-30.