EVALUATION ACUTE AND SUBCHRONIC ORAL TOXICITY OF PASSIFLORA EDULIS EXTRACT IN MICE
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Abstract
Background: Passiflora edulis Sims. (Passifloraceae), a popular herbal medicine in Vietnam, has been used with sedation, anti-inflammatory and antibacterial effects. However, little toxicity data is available regarding its safety. Thus, to evaluate the potential application of Passiflora edulis in health care and treatment, acute and subchronic toxicity data need to be fully studied. Objectives: Evaluation of acute and subchronic oral toxicities of total Passiflora edulis methanolic extract in mice. Materials and methods: The experiment procedures were conducted according to recent toxicity evaluation guidelines. Results: Passiflora edulis extract did not show acute toxicity with the maximum dose of 5000mg/kg. The subchronic toxicity study was studied for 28 days at oral doses of 250mg/kg and 500mg/kg. The results showed that Passiflora edulis extract at doses of 250mg/kg and 500mg/kg being used in 28 days did not have the effects on body weight, locomotor activity, hematopoietic organs, haematological parameters, hepatic and renal function of mice. Histopathological examination of vital organs showed normal architecture suggesting no morphological alterations. Conclusion: Passiflora edulis extract does not cause acute toxicity at the dose of 5000mg/kg and Passiflora edulis extract at doses of 250mg/kg and 500mg/kg being used in 28 days do not show subchronic toxicity.
Keywords
Passiflora edulis Sims, acute toxicity, subchronic toxicity, LD50
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