NGHIÊN CỨU ĐỘC TÍNH CẤP VÀ HOẠT TÍNH KHÁNG VIÊM CỦA CAO TOÀN PHẦN CÂY NGẢI MỌI (GLOBBA PENDULA ROXB.)

Abstract

  Background: Globba pendula Roxb. represents a highly promising medicinal plant for development, owing to growing evidence of its significant chemical constituents and biological activities. Objectives: Evaluation of the acute toxicity and anti-inflammatory activity of the total extract of Globba pendula Roxb. Materials and methods: Acute toxicity was assessed in mice based on the Behrens-Karber method. The in vitro anti-inflammatory activity was assessed through the inhibition of heat-induced albumin denaturation assay. In vivo anti-inflammatory efficacy was tested via carrageenan-induced paw edema in mice. Results: All mice in the experimental groups survived and exhibited no signs of toxicity, the LD₅₀ value of the Globba pendula total extract could not be determined at oral doses up to 11,000 mg/Kg body weight. The IC₅₀ values for the total extract and the reference drug, diclofenac, were 0.932 mg/ml and 0.0897 mg/ml, respectively. The Globba pendula extract group at a dose of 1,000 mg/Kg showed a relatively good level of inflammation reduction, especially from 24 to 72 hours. Conclusion: The total extract of Globba pendula Roxb. does not exhibit acute toxicity at an oral dose of 11,000 mg/Kg. The total extract of Globba pendula Roxb. exhibits concentration-dependent anti-inflammatory potential in vitro. At 1,000 mg/Kg, the total extract of Globba pendula Roxb. significantly suppressed paw edema induced by carrageenan.