RISK FACTORS FOR SEVERITY OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AT CAN THO CENTRAL GENERAL HOSPITAL

Cam Nhung Giang 1,, Thi My Thuy Cao 2
1 Bac Lieu Medical College
2 Can Tho Central General Hospital

Main Article Content

Abstract

Background: Chronic obstructive pulmonary disease remains a major health challenge for globalmedicine because of the popularity, the cost of treating large and high mortality rates. Objectives: To determine the rate and to evaluate some risk factors for the severity of acute exacerbation of Chronic Obstructive Pulmonary disease at Can Tho Central General Hospital. Materials and methods: Descriptive cross-sectional study with analytics on 90 patients in acute exacerbation of Chronic Obstructive Pulmonary Disease. Results: The rate of the severity of acute exacerbation of Chronic Obstructive Pulmonary disease at 72 hours after admission is 31.1%. Risk factors of severe disease at 72 hours after admission: Pulse≥110 times/minute (OR=2.97); SpO2<88% (OR=8.55); contraction of accessory respiratory muscles (OR=9.48); pale (OR=12.73); PaCO2>45mmHg (OR=2.83); GOLD severity of airflow limitation; comorbidities (OR=2.716). Conclusions: The rate of the severity of acute exacerbation of Chronic Obstructive Pulmonary disease at 72 hours after admission is 31.1%. Pulse≥110 times/minute, SpO2<88%, contraction of accessory respiratory muscles, pale, PaCO2>45mmHg, GOLD severity of airflow limitation, comorbidities are risk factors of severe exacerbations at 72 hours after admission.

Article Details

References

1. Trần Xuân Quỳnh, Nguyễn Văn Thành (2015), Nghiên cứu một số yếu tố tiên lượng nặng đợt cấp bệnh phổi tắc nghẽn mạn tính, Tạp chí Y Dược học Cần Thơ, 2.
2. Nguyễn Văn Thành, Cao Thị Mỹ Thúy, Võ Phạm Minh Thư và cộng sự (2012), Xây dựng mô hình hệ thống quản lý và điều trị hiệu quả COPD và Hen phế quản trong bệnh viện và cộng đồng, NXB Y học.
3. Huỳnh Văn Thừa, Trần Ngọc Dung, Đoàn Thị Kim Châu (2019), Kết quả điều trị và một số yếu tố liên quan đến kết quả điều trị ở bệnh nhân đợt cấp bệnh phổi tắc nghẽn mạn tính điều trị nội trú tại bệnh viện Đa khoa Trung tâm An Giang năm 2018-2019, Tạp chí Y Dược học Cần Thơ, tr. 21.
4. Aburto M, Esteban C, et al. (2011), COPD exacerbation Mortality Prognosis Factors in a Respiratory Care Unit, Arch Bronconeumol, 47 (2), pp. 79-84.
5. Anthonisen NR, Warren CPW, et al. (1987), Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease, Ann Int Med, 106, pp. 196–204.
6. Alexopoulos EC (2015), Frequency and risk factors of COPD exacerbations and hospitalizations: A nationwide study in Greece, Int J Chron Obstruct Pulmon Dis, 10, pp. 2665– 2674.
7. Bollmeier SG, Hartmann AP (2020), Management of chronic obstructive pulmonary disease: A review focusing on exacerbations, American Journal of Health-System Pharmacy, 77(4), pp. 259-268.
8. Global Initiative for chronic Obstructive lung Disease (GOLD), Global strategy for the diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease. Global Initiative for chronic Obstructive lung Disease (GOLD) report updated 2020.
9. Pothirat C, Pothirat T, Liwsrisakun C (2017), Risk Factors of Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease Among Patients Regularly Managed by Pulmonologists, J Med Assoc Thai 2017, 100 (2), pp. 142-148.
10. Roche N, Zureik M, Soussan D et al. (2008), Predictors of outcomes in COPD exacerbation cases presenting to the emergency department, Eur Respir J, 32, pp. 953 – 961.
11. Steer J, Gibson GJ and Bourke SC (2010), Predicting outcomes following hospitalization for acute exacerbations of COPD, QJ Med, 103, pp. 817 – 829.
12. Stiell IG, Clement CM, Aaron SD et al. (2014), Clinical Characteristics associated with adverse events in patients with exacerbation of chronic obstructive pulmonary disease: A prospective cohort study, Canadian Medical Association Journal, 186 (6), pp. 193 – 204.
13. Tam Dang Tan, Zhang S (2017), The Burden of illness related to chronic obstructive pulmonary disease Exacerbations in Québec, Canada, Canada Respiratory Journal, 2017, pp.1-10.
14. Westerik JA, Metting EI (2017), Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD, Respiratory Research, 18(1), 31.
15. WHO (2018), Global Health Estimates 2016: Deaths by Cause, Age, Sex, by Country and by region, pp. 2000-2016.