THE VALUE OF PHIGFBP-1 IN RULING OUT PRETERM BIRTH AMONG WOMEN WITH THREATENED PRETERM LABOR AT CAN THO OBSTETRICS AND GYNECOLOGY HOSPITAL
Main Article Content
Abstract
Background: Threatened preterm labor is a common problem in obstetric practice; however, predicting progression to actual preterm birth remains challenging. Phosphorylated insulin-like growth factor-binding protein-1 (phIGFBP-1) is a biomarker used to predict preterm birth, as it appears in cervicovaginal secretions after early separation between the chorion and decidua. Objectives: 1. To describe the clinical and paraclinical characteristics of pregnant women with threatened preterm labor; 2. To determine the value of phIGFBP-1 in ruling out preterm birth. Materials and methods: A prospective cross-sectional study was conducted on 203 pregnant women diagnosed with threatened preterm labor between 28 and less than 36 weeks of gestation. All participants underwent phIGFBP-1 testing and were followed until delivery to assess pregnancy outcomes. Results: The mean gestational age at admission was 33.27 ± 2.19 weeks. Abdominal pain was the most common reason for admission (85.2%). A closed cervix was observed in 65.5% of cases, while 63.1% had uterine contractions and 61.6% had a cervical length >25 mm. The rate of positive phIGFBP-1 tests was 37.4%. Women with a negative phIGFBP-1 test were more likely to remain undelivered within 7 days (OR=21.96, 95%CI:8.07-59.77; p<0.001) and within 14 days (OR=17.21, 95%CI: 8.31-35.63; p<0.001) compared with those with a positive test. Conclusion: The phIGFBP-1 test is a valuable tool for ruling out imminent preterm birth, particularly within 7– 14 days after testing in women presenting with threatened preterm labor.
Keywords
Threatened preterm labor, phIGFBP-1, actim partus
Article Details
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References
2. Cnota W., Jagielska A., Janowska E., Banas E., Kierach R., et al. Prediction of preterm birth using PAMG-1 test: a single centre experience-preliminary report. Ginekologia Polska. 2022.93(7), 574-577, https://doi.org/10.5603/GP.a2021.0171.
3. Gyokova E.H., Ivanova-Yoncheva Y.G., Popov Y.D., Anzaar A.A., Pradip G., et al. Determination of preterm labour with pIGFBP-1 and cervical biometrics. Folia Medica. 2022.64(2), 302-308, https://doi.org/10.3897/folmed.64.e62153.
4. Clarke E., Ford H., Brennecke S., Mol B.W., Wang R. PhIGFBP-1 to predict preterm birth in asymptomatic women: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2024.300, 262-267, https://doi.org/10.1016/j.ejogrb.2024.07.019.
5. Tripathi R., Tyagi S., Mala Y.M., Singh N., Pandey N.B., et al. Comparison of rapid bedside tests for phosphorylated insulin-like growth factor-binding protein 1 and fetal fibronectin to predict preterm birth. International Journal of Gynaecology and Obstetrics.2016.135(1), 47-50, https://doi.org/10.1016/j.ijgo.2016.03.030.
6. Bộ Y tế. Hướng dẫn chẩn đoán và điều trị các bệnh sản phụ khoa. 2015, 17-19.
7. Hoàng Phương Thảo, Phạm Hải Hà, Nguyễn Thị Huyền Linh. Giá trị của phIGFBP-1 trong dự đoán chuyển dạ đẻ non tại Bệnh viện Phụ Sản Trung ương. Tạp chí Y học Cộng đồng. 2025.66(1), 272-276, https://doi.org/10.52163/yhc.v66iCD1.2016.
8. Actim Oy. Actim Partus® - A rapid test to identify patients at risk of preterm or imminent birth. 2024. https://actimtest.com/actim-partus/.
9. Wong T.T.C., Yong X., Tung, J.S.Z., Lee B.J.Y., Chan J.M.X., Du, et al. Prediction of labour onset in women who present with symptoms of preterm labour using cervical length. BMC Pregnancy and Childbirth. 2021.21(1), 359, https://doi.org/10.1186/s12884-02103828-z.
10. Nguyễn Xuân Mỹ, Phạm Bá Nha, Nguyễn Thái Giang, Nguyễn Thị Thúy Ái, Nguyễn Xuân Thảo, và cộng sự. Nghiên cứu đặc điểm lâm sàng, cổ tử cung và xét nghiệm phIGFBP-1 ở các thai phụ dọa sinh non tại Bệnh viện Phụ sản thành phố Cần Thơ. Tạp chí Y học Việt Nam. 2025.552(3), https://doi.org/10.51298/vmj.v552i3.15098.
11. Conde-Agudelo A., Romero R. Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis. Am J Obstet Gynecol. 2016.214(1), 57-73, https://doi.org/10.1016/j.ajog.2015.06.060.