Thanh bên bài viết
Số lượt xem PDF: 91
PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW OF LICORICE (Glycyrrhiza sp.) - A TRADITIONAL LOCAL HERB FOR THE FUTURE OF MEDICINE
Nội dung chính của bài viết
Tóm tắt
The genus Glycyrrhiza (Fabaceae), with over 30 species, includes plants with abundant medicinal properties that have been prevalently used for a long time in traditional medicine. Today, along with the rapid development of modern medicine, this traditional medicine still plays an important role in the research and development of many new drugs. This report emphasized the contribution of some major components of Cam thao (Licorice), one of the species with multifaceted pharmacological effects and used to produce new drugs. Numerous studies have discovered that Licorice contains important substances that affect the physiological activities of living organisms, such as liquirtin, rhamnoliquirilin, liquiritigenin, prenyllicoflavone A, glucoliquiritin apioside, 1metho-xyphaseolin, shinpterocarpine, shinflavanone, licopyranocoumarin, isoflavone, licoarylcoumarin, glycyrrhizin, and manifold components. In this review, the most recent research results within the last 5 years on the pharmacological effects of Licorice are systemized according to the role of Licorice on nervous, respiratory, digestive, immune, reproductive systems (both male and female) and metabolism. It is predicted that Licorice (Fabaceae) will certainly continue to be the subject of manifold scientific works in the future. The effects that have been interesting in the scientific community recently are: oxidation prevention, memory impairment prevention, weight loss, reproductive function improvement in obese men, and immune system function enhancement in many types of cancer. In addition, previous and ongoing studies have shown that Glycyrrhizin, an active ingredient found in Licorice, is effective against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) because of its antiviral activity. As a result, Licorice can be considered a promising future herbal medicine vital to individual and community health.
Chi tiết bài viết
Từ khóa
Cam thao, Licorice, Glycyrrhiza uralensis, Glycyrrhiza glabra, Glycyrrhiza inflata
Tài liệu tham khảo
2. Aipire A., Mahabati M., Cai S., Wei X., Yuan P., et al. (2020), “The immunostimulatory activity of polysaccharides from Glycyrrhiza uralensis”, PeerJ, 8, e8294.
3. Ayeka P. A., Bian Y., Githaiga P. M., and Zhao Y. (2017), “The immunomodulatory activities of Licorice polysaccharides (Glycyrrhiza uralensis Fisch) in CT 26 tumorbearing mice”, BMC Complementary and Alternative Medicine, 17(1), pp. 1-9.
4. Batiha G. E. S., Beshbishy A. M., El-Mleeh A., Abdel-Daim M. M., and Devkota H. P. (2020), “Traditional uses, bioactive chemical constituents, and pharmacological and toxicological activities of Glycyrrhiza glabra L.(Fabaceae)”, Biomolecules, 10(3).
5. Bisht D., Rashid M., Arya R. K. K., Kumar D., Chaudhary S. K., et al. (2021), “Revisiting Liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: potential pharmacological applications with mechanistic insight”, Phytomedicine Plus, 100206.
6. Chrzanowski J., Chrzanowska A., and Graboń W. (2021), “Glycyrrhizin: An old weapon against a novel coronavirus”, Phytotherapy Research, 35(2), pp. 629-636.
7. Ghorbanlou M., Rostamkhani S., Shokri S., Mahmazi S., Fallah R., et al. (2020), “Possible ameliorating effects of Glycyrrhiza glabra (Licorice) on the sperm parameters in rats under high fat diet”, Endocrine regulations, 54(1), pp. 22-30.
8. Hasan M. K., Ara I., Mondal M. S. A., and Kabir Y. (2021), “Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra”, Heliyon, 7(6), e07240.
9. Kim K. U., Lee S. J., and Lee I. (2020), “Development of an Improved Menopausal Symptom - Alleviating Licorice (Glycyrrhiza uralensis) by Biotransformation Using Monascus albidulus”, J. Microbiol. Biotechnol, 30:178-186.
10. Li F., Liu B., Li T., Wu Q., Xu Z., et al. (2020), “Review of constituents and biological activities of triterpene saponins from Glycyrrhizae Radix et Rhizoma and its solubilization characteristics”, Molecules, 25(17), 3904.
11. National Institute of Medicinal Materials (2020), “A number of medicinal herbs, traditional herbs and medicinal plants are used in the prevention and treatment of acute respiratory infections caused by SARS-CoV-2”.
12. Wang H., Song W., Tao W., Zhang J., Zhang X., et al. (2021), “Identification wild and cultivated licorice by multidimensional analysis”, Food Chemistry, 339, 128111.
13. Wei G., Da H., Zhang K., Zhang J., Fang J., and Yang Z. (2021), “Glycoside compounds from Glycyrrhiza uralensis and their neuroprotective activities”, Natural Product Communications, 16(2), 1934578X21992988.
14. Wu D., Wu T., Liu Q., and Yang Z. (2020), “The SARS-CoV-2 outbreak: what we know”, International Journal of Infectious Diseases, 94, pp. 44-48.
15. Yue S. J., Qin Y. F., Kang A., Tao H. J., Zhou G. S., et al. (2021), “Total flavonoids of Glycyrrhiza uralensis alleviates irinotecan-induced colitis via modification of gut microbiota and fecal metabolism”, Frontiers in immunology, 12, 1588.
16. Zhao S., Yan X., Zhao Y., Wen J., Zhao Z., and Liu H. (2018), “Dihydroisocoumarins from Radix Glycyrrhizae”, Chemistry Central Journal, 12(1), pp. 1-6.
17. Zhu J., Huang R., Yang R., Xiao Y., Yan J., et al. (2021), “Licorice extract inhibits the growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltration”, Cancer cell international, 21(1), pp. 1-18.