Nội dung chính của bài viết
Background: Bacteria causing respiratory infections tend to rapidly increase antibiotic resistance, prolong treatment time, increase treatment costs and increase mortality. Objectives: 1). To determine the proportion of bacterial strains isolated from sputum specimens; 2). To describe the antibiotic resistance of bacterial strains isolated from sputum specimens. Materials and methods: A cross-sectional descriptive study was carried out on 96 patients with positive sputum cultures using convenient sampling method. Results: Streptococcus pneumoniae (44.8%) was found to be the predominant pathogen isolated followed by Klebsiella pneumoniae (20.8%), Acinetobacter baumannii (13.5%) and Staphylococcus aureus (8.3%). The highest resistance was observed with piperacillin, ampicillin, erythromycin, cefaclor, azithromycin. Streptococcus pneumonia isolated were mostly resistant to azithromycin, cefaclor, and erythromycin (85.7%), while 0% resistance was observed for vancomycin, ampicillin and gentamycin. Klebsiella pneumoniae were highly resistant to ampicillin (95%), trimeth/sulfa (85%), and piperacillin (85%). Acinetobacter baumannii had a resistant rate of over 50% to most antibiotics, especially gentamycin and meropenem (84.6%). Staphylococcus aureus were completely resistant to ampicillin, clindamycin, penicillin, while vancomycin resistance was observed among 12.5% of the isolated bacteria. Conclusions: The most common pathogen was Streptococcus pneumoniae, Klebsiella pneumoniae, Acinetobacter baumannii and Staphylococcus aureus. The highest resistance was observed with piperacillin, ampicillin, erythromycin, cefaclor, and azithromycin. Streptococcus pneumoniae was highly resistant to macrolides. Klebsiella pneumoniae was highly resistant to most antibiotics of the 2nd, 3rd generation cephalosporins and beta lactams (penicillin and monobactam). Acinetobacter baumannii showed a noticeable resistance to fluoroquinolones, aminoglycosides, and 4th generation cephalosporins. Staphylococcus aureus was highly resistant to penicillin, lincosamides, fluoroquinolone, while 12.5% vancomycin resistance was observed.
Chi tiết bài viết
sputum specimen, bacteria, antibiotic, antibiotic resistance
Tài liệu tham khảo
2. Quynh D. D., Thuy L. Q., Minh P. Q., Thu N. (2020), “Microbial assessment and antibiotic resistance rates of pathogenic bacteria in trauma patients with mechanical ventilationrelated pneumonia in Viet Duc University Hospital, Vietnam Journal of Medicine and Pharmacy, 487 (1&2), pp. 134-138.
3. Van D. T. T., Truyen N. V. (2019), "Clinical and paraclinical characteristics and outcome of hospital acquired pneumoniae treatment at Intensive Care Unit", Can Tho Journal of Medicine and Pharmacy, 22-25, pp. 206-212 .
4. Goto H., Iwasaki M. (2015), “Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibacterial agents (2011)”, Jpn J Antibiot, 68(2), pp. 10524.
5. Anh L. N. (2020), Characteristics of bacteria and situation of anti-resistance on diseases in human diseases in Ca Mau General Hospital , Medical Specialist II Thesis, Can Tho University of Medicine and Pharmacy.
6. Phuc L. H., Dung T. N., Yen H. T. K. (2019), "The characteristic of bacteria caused of ventilator acquaired pneumoniae at Intensive Care and Toxic Against Unit in Can Tho Central General Hospital", Can Tho Journal of Medicine and Pharmacy, 18, pp. 1-7.
7. Dung L. T. (2017), "Community-acquired pneumonia: characteristics and in-vitro resistance of bacteria at HCMC University Medical center", Medical News, 10/2017, pp. 64-68.
8. Huyen N. N. K. (2016), Clinical, paraclinical characteristics, antibiotic resistance of bacteria isolated in Internal Medicine Department at Can Tho University of Medicine and Pharmacy Hospital in 2015 - 2016, Medical Doctoral Thesis, Can Tho University of Medicine and Pharmacy.
9. Tria S. T. C. (2016), Research on clinical and paraclinical characteristics, identify bacteria causing pneumonia and evaluate treatment results in Internal Medicine Department at Can Tho University of Medicine and Pharmacy Hospital and Respiratory Department at Can Tho Central General Hospital in 2015 - 2016, Medical Doctoral Thesis, Can Tho University of Medicine and Pharmacy.
10. Xin Y., Zhang N. (2017), “The analysis of pathogens distribution and drug resistance of bacteria in sputum samples of pneumoconiosis patients combined with lower respiratory tract infection”, Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 35(1), pp. 58-61.