EFFICACY OF TOPICAL METRONIDAZOLE GEL IN DEMODEXASSOCIATED ACNE AMONG HIGH SCHOOL STUDENTS IN VIETNAM

Tóm tắt

Background: Demodex-associated acne is a chronic dermatological condition in which treatment often requires adjunctive therapy with metronidazole. Topical metronidazole gel has shown potential efficacy; therefore, further evaluation of its role is necessary to optimize management outcomes. Objectives: To evaluate the clinical outcomes of topical metronidazole gel in patients with Demodex-associated acne. Materials and methods: A cross-sectional descriptive study with analytical components was conducted among 34 high school students with Demodexassociated acne in Ben Tre City, Vietnam. All patients received topical metronidazole gel, and treatment outcomes were assessed at 2 and 4 weeks. Results: The mean age of the participants was 16 years, with an equal male-to-female ratio. After 2 weeks of treatment, Demodex density decreased from 1.82 ± 0.39 to 1.71 ± 0.68 (p < 0.05). Clinically, 50.0% of patients achieved a good response at 2 weeks, which increased to 82.4% at 4 weeks. A moderate response was observed in 14.7% at 2 weeks but was absent at 4 weeks. Conclusion: Topical metronidazole gel demonstrated significant efficacy in reducing Demodex density and improving clinical outcomes in acne patients. These findings highlight its role as an effective therapeutic option for Demodex-associated acne.