NORMATIVE DATA FOR PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY (pQCT) BONE PARAMETERS IN VIETNAMESE MEN AND WOMEN

Tóm tắt

Background: Peripheral quantitative computed tomography (pQCT) differentiates between cortical and trabecular bone mineral density (BMD), is better at fracture prediction than areal BMD.  Objectives: To develop sex- and age specific- normative reference data for pQCT derived bone parameters for Vietnamese men and women. Materials and methods: The reference range was constructed with 2152 healthy individuals (1319 women and 833 men) from the Vietnam Osteoporosis Study aged 18 years and older. Bone parameters at 4% and 66% positison of the radius and tibia was measured by pQCT (XCT 2000, Stratec Medizintechnik, Pforzheim, Germany). The reference curves for each parameter were constructed using the Generalized Additive Model for Location Scale and Shape modeling technique. The peak ages for these parameters were determined from change point analysis based on change of mean. Results: Women had a slightly higher mean age compared to men (46 vs. 43 years). As expected, men demonstrated a greater BMI than that of women (23.2 vs. 22.5 kg/m²). About 7.0% of women and 9.4% of men were categorized as obese. Overall, pQCT bone parameters were higher in men than in women. The timing of peak bone parameters varied by skeletal sites: at the radius 4% position, peak vBMD occurred earlier for women than for men (24 vs. 30 years old), whereas at the tibia 4% position, both women and men achieved peak value at an earlier age (before 18 vs. 26 years old).  Conclusion: This study provides gender- and age-specific normative reference data for pQCT bone variables in the Vietnamese population, serving as a valuable resource for interpretation, benefiting not only physicians but also the public.