Cantho Journal of Medicine and Pharmacy

SUICIDAL BEHAVIOR IN ADOLESCENT PATIENT WITH BORDERLINE PERSONALITY DISORDER TRAITS: A CASE REPORT

2026-05-25T06:44:57+07:00

Borderline personality disorder (BPD) is characterized by instability in interpersonal relationships, an intense fear of abandonment, impulsivity, affective instability, and impaired social functioning. We report a case in November 2025 of a 17-year-old female patient who presented and was admitted for depressed mood after intentionally ingesting 18 paracetamol tablets with suicidal intent. The patient exhibited a depressive syndrome with a BECK score of 53. The Child Behavior Checklist - CBCL revealed clinical ranges on the withdrawn/depressed and rule-breaking behavior scales, alongside a borderline clinical range on the aggressive behavior scale. The patient was diagnosed with comorbid severe Major Depressive Disorder with suicidal behavior, Oppositional Defiant Disorder, and Borderline Personality Disorder. A multimodal treatment approach was implemented, comprising pharmacotherapy (Sertraline, Risperidone, and Topiramate) combined with psychotherapy. After 9 days of inpatient treatment, the patient showed a positive clinical response, with marked remission of behavioral symptoms and suicidal ideation.Early identification and timely intervention are crucial to alleviating patient distress and mitigating the broader socioeconomic burden attributed to this condition.

EVALUATION OF EARLY TREATMENT OUTCOMES IN PATIENTS WITH STAGE II–IVA NASOPHARYNGEAL CARCINOMA TREATED WITH CONCURRENT CHEMORADIOTHERAPY AT CAN THO ONCOLOGY HOSPITAL

2026-07-17T02:15:33+07:00

Background: Nasopharyngeal carcinoma (NPC) is a malignancy primarily characterized by representing a major burden among head and neck cancers. Although Vietnam is recorded as a country with a high incidence rate, the reality of disease detection remains limited. Statistical reports indicate that the majority of patients are only diagnosed and treated when the tumor has exceeded the localized stage, progressing to a locally or regionally advanced state. For patients in stages II–IVA, concurrent chemoradiotherapy is currently considered the standard regimen due to its capacity to optimize local disease control while significantly reducing the risk of distant metastasis. Objectives: To describe the clinical characteristics and evaluate the early treatment outcomes of concurrent chemoradiotherapy for stage II–IVA nasopharyngeal carcinoma at Can Tho Oncology Hospital. Materials and methods: A total of 30 patients diagnosed with stage II–IVA nasopharyngeal carcinoma who received concurrent chemoradiotherapy at Can Tho Oncology Hospital from 2024 to 2026 were enrolled. This was a cross-sectional descriptive study with clinical intervention, without a control group, utilizing convenience sampling. Results: Clinical characteristics upon admission were predominantly cervical lymphadenopathy (90%), tinnitus (66.7%), and nasal congestion (50%). The overall complete response (CR) rate was 83.3%; the complete response rates at the primary tumor site and cervical lymph nodes were 93.3% and 92.6%, respectively. The majority of acute treatment-related toxicities were observed at grade 2. Conclusion: Concurrent chemoradiotherapy is a highly effective and feasible treatment strategy for stage II–IVA nasopharyngeal carcinoma, demonstrated by excellent tumor and nodal control, with acute toxicities within an acceptable tolerance level.

OUTCOMES OF TOTAL KNEE ARTHROPLASTY WITH MULTIMODAL ANALGESIA

2026-06-24T02:04:24+07:00

Background: Knee osteoarthritis causes pain and reduced quality of life in older adults. When conservative medical management is no longer effective, total knee arthroplasty (TKA) is considered the definitive treatment. Postoperative pain affects functional recovery, prolongs hospital stay, increases the risk of complications, and reduces patient satisfaction. Objectives: To evaluate the outcomes of total knee arthroplasty using a multimodal analgesia protocol. Materials and methods: A case series of 32 patients with severe knee osteoarthritis who underwent total knee arthroplasty with multimodal analgesia at Can Tho University of Medicine and Pharmacy Hospital from May 2025 to December 2025. Results: Thirty-two patients were followed for 3 months postoperatively. Outcomes were assessed using the 2011 Knee Society Score (KSS 2011). The rates of very good and good objective knee scores were 93.75%, and very good and good subjective functional scores were 87.5%. Complete fulfillment of patient expectations was achieved in 78.13% of cases, and 81.25% of patients reported being very satisfied after surgery. Conclusion: Total knee arthroplasty with multimodal analgesia improves knee joint function, meets patient expectations, and enhances postoperative satisfaction.

CLINICAL AND TREATMENT STATUS OF EPILEPSY AT CAN THO PSYCHIATRIC HOSPITAL

2026-07-16T02:00:18+07:00

Background: Epilepsy is a chronic disease requiring long-term treatment. Evidence on clinical characteristics and treatment among epilepsy outpatients in psychiatric specialty hospitals remains limited. Objectives: 1. To describe clinical characteristics; 2. To describe treatment status and related issues among epilepsy outpatients at Can Tho Psychiatric Hospital in 2023. Materials and methods: A descriptive cross-sectional study included 195 outpatients at Can Tho Psychiatric Hospital from July 1 to October 30, 2023. Data were collected from medical records, face-to-face interviews, and clinical examinations and were analyzed using descriptive statistics. Results: Patients older than 20 years accounted for 51.3%, and 60.0% were male; education was generally limited to primary and lower-secondary school, and 14.4% were illiterate. Family history of epilepsy was 6.2%, and prior brain disorders were reported in 10.8%. Disease duration longer than 5 years accounted for 44.6%, and 67.2% had at least two seizures per month. Generalized tonic-clonic seizures were most common (44.1%). Continuous medication use was reported by 89.7%, while 10.3% had discontinued medication; 90.0% of them stopped abruptly. The main reasons were frustration with long-term treatment (35.0%) and believing they were cured when seizures ceased (35.0%). Among the 20 patients who had discontinued medication, 80.0% reported seizure recurrence within 6 months and 55.0% reported more severe recurrent seizures. Conclusion: Many patients continued to experience at least two seizures per month. Among those with medication discontinuation, most stopped abruptly and reported recurrence within the first 6 months.

THE VALUE OF PHIGFBP-1 IN RULING OUT PRETERM BIRTH AMONG WOMEN WITH THREATENED PRETERM LABOR AT CAN THO OBSTETRICS AND GYNECOLOGY HOSPITAL

2026-07-17T07:48:30+07:00

Background: Threatened preterm labor is a common problem in obstetric practice; however, predicting progression to actual preterm birth remains challenging. Phosphorylated insulin-like growth factor-binding protein-1 (phIGFBP-1) is a biomarker used to predict preterm birth, as it appears in cervicovaginal secretions after early separation between the chorion and decidua. Objectives: 1. To describe the clinical and paraclinical characteristics of pregnant women with threatened preterm labor; 2. To determine the value of phIGFBP-1 in ruling out preterm birth. Materials and methods: A prospective cross-sectional study was conducted on 203 pregnant women diagnosed with threatened preterm labor between 28 and less than 36 weeks of gestation. All participants underwent phIGFBP-1 testing and were followed until delivery to assess pregnancy outcomes. Results: The mean gestational age at admission was 33.27 ± 2.19 weeks. Abdominal pain was the most common reason for admission (85.2%). A closed cervix was observed in 65.5% of cases, while 63.1% had uterine contractions and 61.6% had a cervical length >25 mm. The rate of positive phIGFBP-1 tests was 37.4%. Women with a negative phIGFBP-1 test were more likely to remain undelivered within 7 days (OR=21.96, 95%CI:8.07-59.77; p<0.001) and within 14 days (OR=17.21, 95%CI: 8.31-35.63; p<0.001) compared with those with a positive test. Conclusion: The phIGFBP-1 test is a valuable tool for ruling out imminent preterm birth, particularly within 7– 14 days after testing in women presenting with threatened preterm labor.

VALUE OF SERUM CYSTATIN C IN PREDICTING ACUTE KIDNEY INJURY IN PATIENTS WITH ACUTE DECOMPENSATED HEART FAILURE

2026-08-03T02:42:53+07:00

Background: Acute kidney injury is a common complication in patients with acute decompensated heart failure and is associated with a poor prognosis. Objectives: To evaluate the value of serum cystatin C levels in predicting acute kidney injury in patients with acute decompensated heart failure. Materials and methods: A prospective cohort study was conducted on 106 patients with acute decompensated chronic heart failure admitted to the Department of Cardiology, Can Tho Central General Hospital from June 2024 to December 2025. Results: The incidence of acute kidney injury was 30.2%. Serum cystatin C levels were significantly higher in patients with acute kidney injury than in those without acute kidney injury (p < 0.05). Elevated cystatin C levels were significantly associated with the risk of acute kidney injury OR = 2.86 (1.316.23), p < 0.05. Receiver operating characteristic curve analysis demonstrated that cystatin C had predictive value for acute kidney injury, with an area under the curve of 0.655 (0.538-0.772), p = 0.011. The optimal cut-off value of cystatin C was 1.55 mg/L, with a sensitivity of 71.9% and a negative predictive value of 80.8%. Conclusion: Cystatin C is a valuable biomarker for the prediction of acute kidney injury in patients with acute decompensated heart failure.

CLINICAL, PARACLINICAL FEATURES, OUTCOMES, AND ASSOCIATED FACTORS OF DOSE-DENSE 4AC–4P ADJUVANT CHEMOTHERAPY IN HIGH-RISK BREAST CANCER

2026-06-24T02:02:49+07:00

Background: Breast cancer is a common malignant disease, with an increasing incidence rate, and it poses a significant burden on public health. Dose-dense regimens represent a breakthrough in the management of high-risk breast cancer, optimizing treatment intensity, thereby improving survival and effectively reducing recurrence. Objectives: To describe the clinical and paraclinical characteristics and evaluate factors associated with chemotherapy outcomes in patients with high-risk breast cancer treated with dose-dense 4AC–4P adjuvant chemotherapy. Materials and methods: A cross-sectional descriptive study was conducted on 78 patients diagnosed with breast cancer who received dose-dense 4AC–4P adjuvant chemotherapy at Can Tho Oncology Hospital from May 2024 to January 2026. Results: The mean age in the study was 47.79 ± 7.33 years, with the 41–50 age group accounting for the majority (47.4%). The ≤ 40-year-old group had a higher rate of family history of related diseases compared with the >40-year-old group, and the association was statistically significant (OR = 6.9; KTC 95%: 4.000–11.934; p = 0.026). Patients with a history of chronic diseases had a higher rate of vomiting compared with those without (37.5% versus 17.4%), and the association was statistically significant (OR = 2.85; 95% CI: 1.002–8.109; p = 0.045). Conclusion: A family history of breast cancer is a major risk factor in younger patients, indicating the need for genetic counseling at the time of diagnosis. Chemotherapy-related vomiting is increased in patients with concomitant chronic diseases and requires more thorough evaluation and control in this population.

THE ANTIBACTERIAL EFFICACY OF NATRI HYPOCLORIT AND CALCIUM HYDROXIDE IN ENDODONTIC TREATMENT OF CHRONIC PERIAPICAL INFLAMMATION IN SINGLE-ROOT TOOTH

2026-05-12T02:01:42+07:00

Background: Enterococcus faecalis is one of the causes of chronic periapical inflammation, with a detection rate of approximately 20%-30% of primary infections and 67%-77% of secondary infections in periapical lesions. The effectiveness of sodium hypochlorite combined with calcium hydroxide in eradicating E. faecalis in endodontic practice is currently under investigation. Objectives: To evaluate the effectiveness of sodium hypochlorite and calcium hydroxide in eradicating Enterococcus faecalis in the root canals of patients with chronic periapical inflammation in single-rooted teeth. Materials and methods: A clinical intervention study without a control group, evaluating effectiveness using a before-and-after model, was conducted on 52 patients over 18 years old, diagnosed and who received endodontic treatment for chronic periapical inflammation in single-rooted teeth at Phu Nhuan General Hospital from June 2025 to February 2026. Bacterial counts were recorded at the time of access to the pulp of root canal treatment (T0) and after root canal preparation, using 3% NaOCl irrigation and Ca(OH)2 placement for 2 weeks (T1). Results: The average bacterial count recorded at time T0 was 1.6x106 ± 2.3x106 (DU/ml) and at T1 was 0.4 x106 ± 0.7x106 (DU/ml), this difference was statistically significant (p<0.05). At the 3-month follow-up, the success rate reached 90.4%. Conclusion: The combined use of 3% NaOCl irrigation and Ca(OH)2 placement showed good antibacterial efficacy against E. faecalis in the treatment of chronic periapical inflammation.

PRELIMINARY EVALUATION OF SURGICAL TREATMENT FOR ACROMIOCLAVICULAR JOINT DISLOCATION USING CORACOCLAVICULAR AND ACROMIOCLAVICULAR LIGAMENT RECONSTRUCTION

2026-05-25T07:51:00+07:00

Background: Acromioclavicular joint dislocation is a common injury following shoulder trauma; however, the optimal treatment strategy remains controversial. Traditional treatment methods may have limitations in maintaining joint stability and may not fully restore the anatomy of the coracoclavicular ligament complex. Therefore, anatomical reconstruction of the coracoclavicular and acromioclavicular ligaments using biological grafts has received increasing attention. Objectives: To evaluate the preliminary outcomes of surgical treatment for acromioclavicular joint dislocation using coracoclavicular and acromioclavicular ligament reconstruction. Materials and methods: This prospective descriptive study included 30 patients with acromioclavicular joint dislocation who underwent coracoclavicular and acromioclavicular ligament reconstruction at Can Tho Central General Hospital, Can Tho General Hospital, and Can Tho University of Medicine and Pharmacy Hospital from June 2024 to December 2025. Treatment outcomes were assessed based on clinical characteristics, operative time, complications, shoulder function according to the Constant–Murley score, and patient satisfaction at 3 months after surgery. Results: The mean age of the patients was 45.00 ± 12.10 years, with males accounting for the majority. Rockwood type V acromioclavicular joint dislocation was the most common injury pattern. The mean time from injury to surgery was 10.17 ± 8.39 days, and the mean operative time was 89.50 ± 10.62 minutes. The Constant–Murley score improved from 29.60 ± 5.88 before surgery to 77.70 ± 5.31 at 3 months postoperatively. The rate of good and excellent outcomes reached 100%. The most common complication was loss of acromioclavicular joint reduction. The rate of satisfied and very satisfied patients was 93.33%. Conclusion: Coracoclavicular and acromioclavicular ligament reconstruction is an effective treatment method for acromioclavicular joint dislocation, helping improve joint stability and shoulder function after surgery.

EVALUATION OF CLINICAL PROFILES AND SURGICAL RESULTS FOR PEDIATRIC OTITIS MEDIA WITH EFFUSION WITH ADENOID HYPERTROPHY AT CAN THO CHILDREN'S HOSPITAL AND CAN THO

2026-05-12T02:57:19+07:00

Background: A significant proportion of pediatric otorhinolaryngology cases involve adenoid hypertrophy, which commonly predisposes patients to otitis media with effusion (OME). If not managed appropriately and timely, pediatric patients may experience recurrence, hearing loss, or other significant complications. Objectives: To describe the clinical and sub-clinical characteristics and evaluate the therapeutic outcomes of 45 patients with OME and adenoid hypertrophy at Can Tho Children's Hospital and Can Tho Ear, Nose, and Throat Hospital. Materials and methods: A cross-sectional, prospective interventional study was conducted on 45 pediatric patients diagnosed with OME and adenoid hypertrophy from June 2024 to August 2025. Results: The prevalence was higher in males (57.8%) than in females (42.2%). Otoscopic findings revealed tympanic membrane retraction in 58.5% of cases and bulging in 12.2%. Preoperative tympanometry primarily showed Type B curves (81.7%). The majority of patients (62.2%) presented with Grade III adenoid hypertrophy. The success rate of endoscopic ventilation tube insertion combined with adenoidectomy reached 95.6%. Conclusion: Endoscopic ventilation tube insertion combined with adenoidectomy yields positive therapeutic outcomes.

EVALUATION OF THE TREATMENT EFFECTIVENESS OF TAO HONG SI WU TANG COMBINED WITH ELECTROACUPUNCTURE, MAGNETIC THERAPY IN PATIENTS WITH LUMBAR DISC HERNIATION

2026-07-06T07:00:17+07:00

Background: Lumbar disc herniation is a common musculoskeletal disorder and a leading cause of low back pain and sciatica. The condition limits physical function, reduces work capacity, and significantly impairs patients' quality of life. It is considered one of the leading causes of work absenteeism in Vietnam as well as worldwide. Objectives: 1) To evaluate the therapeutic efficacy of Tao Hong Si Wu Tang combined with electroacupuncture and magnetic field therapy in patients with lumbar intervertebral disc herniation; 2) To investigate several factors associated with treatment outcomes. Materials and methods: This study was conducted on 35 inpatients diagnosed with lumbar disc herniation at Can Tho Traditional Medicine Hospital. The study was designed as an uncontrolled clinical intervention study. Results: After 14 days of treatment, significant clinical improvement was observed. The mean VAS score decreased from 6.97 ± 0.30 to 4.51 ± 1.07 (p < 0.01). The Schober index increased from 11.24 ± 0.33 cm to 12.40 ± 0.68 cm, while the fingertip-tofloor distance decreased from 41.63 ± 7.26 cm to 15.89 ± 6.29 cm (p < 0.01). The proportions of patients with good and fairly good treatment outcomes reached 8.6% and 82.8%, respectively, whereas the proportion with poor outcomes decreased from 82.9% to 2.9%. Age and body mass index (BMI) were not significantly associated with treatment outcomes (p > 0.05). Conclusion: The combination of Tao Hong Si Wu Tang herbal formula, electroacupuncture, and magnetic field therapy reduced pain and improved lumbar spine range of motion in patients with lumbar disc herniation after 14 days of treatment.

EARLY OUTCOMES OF LAPAROSCOPIC RIGHT HEMICOLECTOMY WITH D3 LYMPHADENECTOMY FOR RIGHT-SIDED COLON CANCER

2026-05-12T03:24:36+07:00

Background: Laparoscopic right hemicolectomy was first performed by Jacobs in 1991. To date, this procedure is considered the gold standard for treating right-sided colon cancer, offering superior advantages over open surgery. However, surgical principles remain controversial; while Complete Mesocolic Excision (CME) with Central Vascular Ligation (CVL) is prominent in Western countries, D3 lymph node dissection based on observations of regional lymph node metastasis-has become the standard of care for colon cancer surgery in Japan. Objectives: To evaluate the early outcomes within 30 days following laparoscopic right hemicolectomy combined with D3 lymph node dissection in the treatment of right-sided colon cancer. Materials and methods: A non-controlled clinical intervention study was conducted on 41 patients with right-sided colon cancer who underwent D3 lymphadenectomy at Can Tho University of Medicine and Pharmacy Hospital from July 2024 to October 2025. Results: Male/Female ratio: 19/22. Mean age: 63 ± 12.8 years. Surgical technique: Dissection of the left border of the superior mesenteric vein (SMV) and harvest of the main lymph node group (D3) were achieved in 100% of cases. Mean operative time: 187.61 ± 52.04 minutes. Mean blood loss: 74.39 ± 31.7 ml. The average number of dissected lymph nodes: 15.73 ± 4.2. The mean number of metastatic lymph nodes was 0.83 ± 1.68. Mean postoperative hospital stay: 7.9 ± 2 days. Postoperative complications: Surgical site infection occurred in 6 patients (14.6%); none had anastomotic leakage. Conclusion: Laparoscopic right hemicolectomy with D3 lymph node dissection is a safe and feasible method for the treatment of right-sided colon cancer.

THE OUTCOMES OF MINIMALLY INVASIVE PLATE OSTEOSYNTHESIS IN THE TREATMENT OF MIDSHAFT CLAVICLE FRACTURE

2026-05-25T08:06:01+07:00

Background: Clavicle fractures are among the most common fractures of the upper extremity. Open reduction and internal fixation have demonstrated earlier fracture union and a lower rate of nonunion compared with conservative treatment. However, conventional open surgery with a long incision is associated with certain complications. Minimally invasive locking plate osteosynthesis (MIPO) can mitigate these complication rates due to smaller incisions, less soft-tissue disruption, and better preservation of periosteal blood supply. Objectives: To evaluate the outcomes of minimally invasive locking plate osteosynthesis under fluoroscopic guidance in the treatment of midshaft clavicle fractures. Materials and methods: A prospective cross-sectional descriptive study was conducted on 15 patients with closed midshaft clavicle fractures. All patients underwent MIPO fixation using locking plates between February 2025 and December 2025. Results: The mean age was 39.7 ± 11.3 years. The average incision length was 2.5 ± 0.5 cm. All patients achieved solid bone union at 6 months postoperatively. The mean Constant-Murley score was 86.5 ± 5.8, indicating good functional recovery. Conclusion: Minimally invasive locking plate osteosynthesis under fluoroscopic guidance is a safe and effective technique. The MIPO technique preserves the periosteal blood supply is critical for maximizing osteogenesis and ensuring optimal cosmetic outcomes.

ANTIDEPRESSANT EFFECT OF TOTAL EXTRACT FROM LOTUS PLUMULE (NELUMBINIS SEMEN) IN A METHYLPREDNISOLONE- INDUCED STRESS MODEL IN MICE

2026-07-07T02:06:00+07:00

Background: Chronic elevation of corticosterone leading to dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis may negatively affect neuroregulation and contribute to depressive-like behaviors. Nelumbinis Semen (lotus plumule) is a traditional medicinal herb widely used for its sedative and anxiolytic properties and has demonstrated neuroprotective potential in several experimental depression models. Objectives: This study aimed to establish a methylprednisolone-induced depressive-like mouse model and investigate the antidepressant effects of the total extract of Nelumbinis Semen. Materials and methods: Male Swiss albino mice (22 ± 2 g) received subcutaneous methylprednisolone (20 mg/kg/day) for 21 days to induce depressive-like behaviors. Animals were subsequently treated for 14 days with fluoxetine (10 mg/kg) or Nelumbinis Semen extract (200 mg/kg, oral administration). Behavioral assessments included the forced swimming test (FST), tail suspension test (TST), elevated plus maze (EPM), and light–dark test (L/D). Results: Prolonged methylprednisolone administration significantly increased immobility time in both FST and TST compared with the control group (p < 0.05), indicating successful induction of depressive-like behavior. Treatment with Nelumbinis Semen extract at 200 mg/kg or fluoxetine (10 mg/kg) significantly reduced immobility time in FST and TST. Additionally, antidepressant-like effects were evidenced by increased time spent in the open arms of the EPM and in the light compartment of the light–dark test compared with the disease model group. Conclusion: Chronic subcutaneous administration of methylprednisolone successfully induced depressive-like behaviors in mice. Concurrently, the antidepressant effect of Nelumbo nucifera embryo total extract at a dose of 200 mg/kg was demonstrated using this model.

APPLICATION OF IMMUNOBLOT TECHNIQUE IN ALLERGEN IDENTIFICATION IN ALLERGIC PATIENTS AT CAN THO DERMATOLOGY HOSPITAL

2026-07-05T09:58:30+07:00

Background: Immunoblotting enables precise determination of specific IgE against individual allergen components. This provides further scientific evidence for allergen avoidance, supports the assessment of allergy severity, and guides the selection of appropriate personalized treatment options for patients. Objectives: To determine the prevalence and detection levels of common allergens using immunoblotting in allergic specimens at Can Tho Dermatology Hospital. Materials and methods: A cross-sectional descriptive study with analytical components was conducted on 182 specimens from allergic patients submitted to the Laboratory Department of Can Tho Dermatology Hospital from October 2024 to September 2025. Results: The study results showed that 70.9% of specimens were positive for at least one allergen. Among the 58 detected allergens, 15 exhibited the highest prevalence. The three most common allergens were Dermatophagoides farinae (54.9%), Dermatophagoides pteronyssinus (34.6%), and house dust (30.2%). Notably, allergens with strong, very strong, and extremely strong positive reactions were predominantly cockroach (6.6%), D. farinae (4.9%), and D. pteronyssinus (4.4%). In contrast, several allergens showed the lowest positivity rate (0.5%), including wheat, flounder/Alaska pollock, squid, and cheese/hard cheese. Most positive specimens reacted to two or more allergens (86.8%), while only 13.2% were positive to a single allergen. Conclusion: In our study, the overall allergen positivity rate was 70.9%, with 15 specific allergens exhibiting the highest positivity rates. Cockroach was the most prevalent allergen, followed by the house dust mites D. farinae and D. pteronyssinus.

EFFECTIVENESS OF ACUPRESSURE MASSAGE, ELECTROACUPUNCTURE COMBINED, SHORTWAVE THERAPY AND V.PHONTE IN THE TREATMENT OF KNEE OSTEOARTHRITIS

2026-05-25T07:53:28+07:00

Background: Knee osteoarthritis causes pain and limited of movement. Current treatment mainly focuses on symptom relief but has limitations, while prolonged medication use may cause adverse effects. Combining traditional medicine modalities with physical therapy may contribute to improving treatment outcomes. Objectives: To evaluate the effectiveness of acupressure massage, electroacupuncture, and shortwave therapy combined with V.phonte in reducing pain and improving knee joint function compared with electroacupuncture and shortwave therapy combined with V.phonte. Materials and methods: A controlled clinical intervention study with before-and-after treatment comparisons was conducted in 78 patients with primary knee osteoarthritis diagnosed according to the 1991 American College of Rheumatology (ACR) criteria, with 39 patients in each group. The study was conducted at the HCMC Hospital for Rehabilitation - Professional Diseases and Phu Lam Ward Health Station, Ho Chi Minh City, from April to December 2025. Results: After 10 days of treatment, the VAS score decreased from 5.38±0.54 to 1.21±0.57 in the intervention group and from 5.31±0.47 to 2.44±0.55 in the control group (p<0.05). The Lequesne index decreased from 13.56±2.95 to 5.96±3.56 in the intervention group and from 13.56±2.77 to 8.06±2.86 in the control group (p<0.05). The intervention group showed greater improvement in knee range of motion than the control group (p<0.05). Several traditional medicine symptoms improved after treatment in both groups, although no statistically significant differences were observed between the groups (p>0.05). Conclusion: Adding acupressure massage to electroacupuncture, shortwave therapy, and V.phonte resulted in greater pain reduction and improvement in knee joint function than the same regimen without acupressure massage.

EVALUATION OF TREATMENT OUTCOMES OF LUMBAR DISC HERNIATION TREATED WITH UNILATERAL BIPORTAL ENDOSCOPIC SURGERY

2026-06-22T16:57:47+07:00

Background: Lumbar disc herniation is a common spinal disorder that significantly affects patients’ quality of life and work capacity. Unilateral biportal endoscopic (UBE) lumbar discectomy is a minimally invasive surgical technique that provides effective pain relief and functional improvement following surgery. Objectives: To evaluate the efficacy and safety of unilateral biportal endoscopic lumbar discectomy in the treatment of lumbar disc herniation. Materials and methods: This is an analytical cross-sectional study including 31 patients diagnosed with single-level lumbar disc herniation who underwent UBE lumbar discectomy at Can Tho University of Medicine and Pharmacy Hospital. Pain intensity and functional outcomes were assessed preoperatively and at the time of hospital discharge using the Visual Analogue Scale (VAS) and the modified MacNab criteria. Results: The mean VAS score significantly decreased from 7.52 (leg pain) and 4.06 (low back pain) preoperatively to 2.52 and 1.77 postoperatively, respectively. The mean operative time was 95.35 ± 24.26 minutes. The mean postoperative hospital stay was 4.52 ± 1.48 days, indicating rapid recovery and early return to normal activities. According to the modified MacNab criteria, 100% of patients achieved either “Excellent” or “Good” outcomes, accounting for 70.97% and 29.03%, respectively. No intraoperative or postoperative complications were observed. Conclusion: Unilateral biportal endoscopic lumbar discectomy is an effective and safe surgical technique for the treatment of lumbar disc herniation, providing significant pain reduction, functional improvement, shorter hospital stays, and a low complication rate.

ANTIMICROBIAL RESISTANCE PATTERNS AND TREATMENT OUTCOMES OF VENTILATOR-ASSOCIATED PNEUMONIA CAUSED BY ACINETOBACTER BAUMANNII IN PATIENTS WITH STROKE

2026-07-06T10:22:21+07:00

Background: Ventilator-associated pneumonia is a common infectious complication in patients with stroke requiring respiratory support. Multidrug-resistant Acinetobacter baumannii is an important pathogen associated with high rates of treatment failure and mortality. Objectives: To investigate the clinical characteristics, laboratory findings, antimicrobial resistance patterns, predictors of mortality, and treatment outcomes in patients with stroke and ventilator-associated pneumonia caused by Acinetobacter baumannii. Materials and methods: A prospective study was conducted in 89 patients with stroke (either previously diagnosed or newly diagnosed) who developed ventilator-associated pneumonia caused by Acinetobacter baumannii and were treated at Can Tho Central General Hospital from July 2024 to May 2026. Results: Among the 89 patients, the mean age was 67.8 years; hypertension was present in 82.0% of patients, and early-onset ventilator-associated pneumonia accounted for 75.3% of cases. Acinetobacter baumannii was resistant to most antimicrobial agents, except for colistin, with a resistance rate of 1.8%. Older age, a history of intravenous antibiotic use within the previous 90 days, renal replacement therapy, and failure to respond to empiric antibiotic therapy were identified as independent predictors of mortality. The 30-day mortality rate was 42.7%. Conclusion: Ventilator-associated pneumonia caused by Acinetobacter baumannii in patients with stroke is associated with high rates of antimicrobial resistance and mortality. Colistin remains effective against the majority of isolates. Factors related to epidemiological characteristics, prior antibiotic exposure, and response to initial empiric antibiotic therapy have a significant impact on the risk of mortality and should be identified early to optimize treatment.

CLINICAL AND PARACLINICAL CHARACTERISTICS AND TREATMENT OUTCOMES OF PATIENTS WITH ALIMENTARY TRACT FOREIGN BODIES AT CHO RAY HOSPITAL AND CAN THO CITY

2026-07-05T10:36:39+07:00

Background: Foreign bodies in the alimentary tract are a common emergency in Otolaryngology. Delayed diagnosis and management may lead to esophagitis, perforation, or periesophageal abscess. Objectives: To describe the clinical and paraclinical characteristics and evaluate treatment outcomes in patients with alimentary tract foreign bodies. Materials and methods: A cross-sectional descriptive study was conducted on 42 hospitalized patients treated at Cho Ray Hospital, Can Tho ENT Hospital and Can Tho Central General Hospital from May 2025 to April 2026. Data were processed and analyzed using SPSS version 20.0. Results: The mean age was 49.93 ± 18.84 years, with an equal male-to-female ratio (50%). Odynophagia was the most common symptom (71.4%). Most foreign bodies were located in the cervical esophagus (83.3%), with fish bones accounting for 57.1%. CT scans detected foreign bodies in 95% of indicated cases. Admission after 24 hours increased the risk of complications. Good treatment outcomes were achieved in 40.5% of patients. Conclusion: Delayed admission was associated with complications. Early intervention within the first 24 hours plays a crucial role in reducing complications and improving treatment outcomes.

PAIN SYMPTOMS AND ANALGESIC TREATMENT IN CANCER PATIENTS AT THE ONCOLOGY DEPARTMENT OF CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

2026-07-05T10:43:53+07:00

Background: Malignancy-associated pain causes not only physical suffering but also impacts mental health and quality of life, while potentially compromising treatment outcomes. Assessing current symptom characteristics and analgesic patterns is vital to underscore the necessity for advanced pain care for oncology patients. Objectives: To describe the pain profiles and pharmacological interventions and their associated factors among cancer patients at the Oncology Department, Can Tho University of Medicine and Pharmacy Hospital. Materials and methods: A cross-sectional descriptive study was conducted on 85 cancer patients presenting with pain symptoms and receiving analgesic treatment. Results: Pain severity was mild in 40.0%, moderate in 51.8%, and severe in 8.2% of patients. Nociceptive pain was the most prevalent type (85.9%), alongside mixed (12.9%) and neuropathic pain (1.2%). The incidence of neuropathic or mixed pain was significantly lower in patients with a normal BMI compared to underweight individuals (p = 0.008). Regarding treatment, analgesic monotherapy was utilized in 48.2% of cases. Analgesic combination rates were 42.4% for acetaminophen, 15.3% for neuropathic adjuvants, and 8.2% for NSAIDs. Notably, combination analgesia was employed significantly more often in patients with mild pain than those with moderate-to-severe pain (p < 0.001). Conclusion: Moderate pain was the most prevalent intensity, typically occurring via nociceptive or mixed pathways. The study indicates that patients with a normal BMI status had a lower prevalence of neuropathic or mixed pain mechanisms compared to the underweight group. Clinical focus must shift toward optimizing combination therapies. Early nutritional support to preserve physical status may attenuate multifactorial pain mechanisms.

EVALUATION OF THE CAPABILITY OF QURE.AI TOOL IN DETECTING CHEST X-RAY LESIONS IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA

2026-07-14T16:08:31+07:00

Background: The application of Artificial Intelligence (AI) in diagnostic imaging is increasingly widespread and has become a major trend in modern medicine. Pneumonia is a common infectious disease associated with high mortality. The use of AI in analyzing chest X-rays helps in early detection and improves diagnostic accuracy. Objectives: To evaluate the value of the Qure.ai tool in analyzing chest X-ray images in patients with community-acquired pneumonia. Materials and methods: A cross-sectional descriptive study was conducted on 311 patients with community-acquired pneumonia admitted to Can Tho Central General Hospital and Can Tho University of Medicine and Pharmacy Hospital from June 2025 to January 2026. Chest X-ray images were analyzed using the Qure.ai tool and compared with the reference standard. The kappa coefficient, sensitivity, specificity, and diagnostic values were calculated using SPSS 27.0 software. Results: The mean age of the patients was 71.3 ± 13.4 years. The level of agreement between Qure.ai and radiologists in detecting pneumonia-related lesions ranged from moderate to high. Pleural effusion lesions showed the highest level of agreement (κ = 0.708). In the subgroup of patients who underwent chest computed tomography as the gold standard, Qure.ai detected consolidation/opacity lesions with a sensitivity of 91.7%. Among the 60 cases with confirmed lesions on chest CT, the Qure.ai tool exhibited higher sensitivity compared to radiologists (98.3% versus 91.7%), though the difference was not statistically significant (p = 0.125). Conclusion: Qure.ai demonstrates significant potential as a supportive tool for detecting pneumonic lesions on chest radiographs.

THE PREVALENCE OF MACULAR OEDEMA AND RELATED FACTORS AT TYPE 2 DIABETIC PATIENTS IN CAN THO CITY

2026-06-28T17:20:10+07:00

Background: Diabetic macular edema and diabetic retinopathy are common microvascular complications in diabetic patients. Numerous studies have shown that macular edema is a major cause of vision loss and vision impairment in diabetic patients. Early detection and timely treatment of macular edema is an effective strategy for preventing vision loss in diabetic patients and improving their quality of life. Objectives: This study investigates the prevalence of diabetic macular edema and diabetic retinopathy, and some related factors in type 2 diabetic patients. Materials and methods: This prospective descriptive, cross-sectional study with analytical components was conducted on 120 diabetic patients with ocular complications in Can Tho City, from June 2025 to January 2026. All patients were screened for macular edema and diabetic retinopathy using Optical Coherence Tomography. Macular edema is defined as retinal thickening of 500 µm within two optic disc diameters from the macula. Results: Diabetic macular edema accounts for 25.8% (31 patients), while diabetic retinopathy accounts for 54.2% (65 patients). Diabetic macular edema is associated with a duration of diabetes exceeding 10 years, hypertension, blood glucose levels, and HDL levels. Conclusion: Macular edema can cause blindness. Attention should be paid to macular edema in diabetic patients with a duration of diabetes exceeding 10 years, especially those with poorly controlled blood glucose, blood pressure, and lipid disorders. To prevent macular edema and diabetic retinopathy, and to slow disease progression, good management of blood glucose, blood pressure, and cholesterol is essential.

PREVALENCE AND ASSOCIATED FACTORS OF PREECLAMPSIA IN WOMEN WITH GESTATIONAL DIABETES MELLITUS AT CAN THO OBSTETRICS AND GYNECOLOGY HOSPITAL IN 2024-2026

2026-07-07T15:45:29+07:00

Background: Preeclampsia is a serious obstetric complication and a leading cause of maternal and perinatal morbidity and mortality. Gestational diabetes mellitus is considered an important risk factor for preeclampsia. Objectives: To determine the prevalence and identify factors associated with preeclampsia among women with gestational diabetes mellitus at Can Tho Obstetrics and Gynecology Hospital from 2024 to 2026. Materials and methods: A prospective cohort study with analytical components was conducted on 400 pregnant women diagnosed with gestational diabetes mellitus who attended antenatal care at Can Tho Obstetrics and Gynecology Hospital from June 2024 to February 2026. Multivariable logistic regression analysis was performed to identify factors independently associated with preeclampsia. Results: The prevalence of preeclampsia was 18.3%. Among affected cases, 82.2% had preeclampsia without severe features and 41.1% were preterm preeclampsia. Preeclampsia was independently associated with maternal age (OR = 3.03; 95% CI: 1.76–5.22) and pre-pregnancy BMI (OR = 1.99; 95% CI: 1.44 – 2.73). Conclusion: Preeclampsia was common among women with gestational diabetes mellitus, and early identification of risk factors may help improve pregnancy management and maternal - perinatal outcomes.

A STUDY OF THE ACUTE TOXICITY AND ANTI-INFLAMMATORY EFFICACY OF THE TOTAL EXTRACT OF GLOBBA PENDULA ROXB.

2026-07-07T16:49:23+07:00

Background: Globba pendula Roxb. represents a highly promising medicinal plant for development, owing to growing evidence of its significant chemical constituents and biological activities. Objectives: Evaluation of the acute toxicity and anti-inflammatory activity of the total extract of Globba pendula Roxb. Materials and methods: Acute toxicity was assessed in mice based on the Behrens-Karber method. The in vitro anti-inflammatory activity was assessed through the inhibition of heat-induced albumin denaturation assay. In vivo anti-inflammatory efficacy was tested via carrageenan-induced paw edema in mice. Results: All mice in the experimental groups survived and exhibited no signs of toxicity, the LD50 value of the Globba pendula total extract could not be determined at oral doses up to 11,000 mg/Kg body weight. The IC50 values for the total extract and the reference drug, diclofenac, were 0.932 mg/ml and 0.0897 mg/ml, respectively. The Globba pendula extract group at a dose of 1,000 mg/Kg showed a relatively good level of inflammation reduction, especially from 24 to 72 hours. Conclusion: The total extract of Globba pendula Roxb. does not exhibit acute toxicity at an oral dose of 11,000 mg/Kg. The total extract of Globba pendula Roxb. exhibits concentration-dependent anti-inflammatory potential in vitro. At 1,000 mg/Kg, the total extract of Globba pendula Roxb. significantly suppressed paw edema induced by carrageenan.

PREVALENCE OF EPSTEIN-BARR VIRUS INFECTION AND ASSOCIATED FACTORS IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA

2026-07-07T16:52:14+07:00

Background: Nasopharyngeal Carcinoma is one of the most common head and neck cancers in Southeast Asia and Vietnam. Epstein-Barr virus is considered closely associated with the pathogenesis of the disease, particularly in non-keratinizing histological types. Objectives: To determine the prevalence of EBV infection detected by real-time PCR and its associated factors in patients with nasopharyngeal carcinoma at Can Tho Oncology Hospital. Materials and methods: A cross-sectional descriptive study with analytical components was conducted on 37 patients histopathologically diagnosed with nasopharyngeal carcinoma. EBV-DNA was performed on plasma samples using real-time PCR. Results: The prevalence of EBV-DNA was 73.0%. Male patients accounted for 75.7%, with a mean age of 53.5 ± 14.2 years. Type III was the most common histopathological type (51.4%). Most patients were diagnosed at stage III (73.0%). No statistically significant association was observed between EBV infection status and sex, age group, occupation, histopathological type, or disease stage (p > 0.05). Conclusion: EBV-DNA was detected at a high rate in patients with nasopharyngeal carcinoma. EBV infection tended to be associated with histopathological characteristics and disease stage; however, these associations did not reach statistical significance in this study.

PROGNOSTIC VALUE OF THE SNAP-II SCORE FOR NEONATAL MORTALITY AT CAN THO CHILDREN’S HOSPITAL

2026-07-16T09:51:19+07:00

Background: Neonatal mortality remains a major challenge in neonatal intensive care units. The SNAP-II score is widely used to assess physiological severity and predict early neonatal mortality. Although several studies have evaluated its prognostic value in Vietnam, no study has been conducted in the Mekong Delta. Objectives: To evaluate the prognostic value of the SNAP-II score for predicting neonatal mortality at the Neonatal Department of Can Tho Children's Hospital. Materials and methods: A cross-sectional analytical study was conducted on 84 neonates admitted to the Neonatal Intensive Care Unit, Can Tho Children's Hospital, from January 2025 to February 2026. SNAP-II scores were recorded within the first 24 hours after admission. Prognostic performance was assessed using receiver operating characteristic (ROC) analysis and multivariable logistic regression. Results: The mortality rate was 20.2%. SNAP-II scores were significantly higher in non-survivors than in survivors (12 versus 5 points; p=0.001). The area under the ROC curve was 0.734 (95% CI: 0.591–0.877; p=0.003). The optimal cut-off value was ≥ 9.5, with a sensitivity of 58.8% and a specificity of 79.1%. After adjustment for sex and prematurity, a SNAP-II score ≥ 9.5 was independently associated with mortality (adjusted OR=5.27; 95% CI: 1.68–16.54; p=0.004). Conclusion: The SNAP-II score is an independent predictor of neonatal mortality and can support early risk stratification in neonatal intensive care units.

CARBAPENEM-RESISTANT GRAM-NEGATIVE BACTERIA AND CEFTAZIDIME/AVIBACTAM USE AT HAI PHONG INTERNATIONAL HOSPITAL, 2022-2024

2026-05-25T06:46:24+07:00

Background: Ceftazidime/avibactam is a new-generation antibiotic used in the treatment of infections caused by carbapenem-resistant Gram-negative bacteria; however, due to its high treatment cost and reported antimicrobial resistance, monitoring and evaluation of its clinical use are necessary. Objectives: To describe the status of carbapenem-resistant Gram-negative bacteria and to analyse the appropriateness of ceftazidime/avibactam use at Hai Phong International Hospital during the period 2022–2024. Materials and methods: A retrospective descriptive study was conducted on 3,936 clinical specimens with positive cultures for Gram-negative bacteria and electronic medical record data of 14 patients with 18 courses of ceftazidime/avibactam treatment at study hospital from 1 January 2022 to 31 December 2024. Results: The most common Gram-negative pathogens were E. coli (58.16%), K. pneumoniae (11.51%) and P.aeruginosa (8.30%). E. coli exhibited a low rate of meropenem resistance, increasing from 0.34% in 2022 to 2.28% in 2024. In contrast, K. pneumoniae and P. aeruginosa showed higher meropenem resistance rates but a decreasing trend during the study period. Ceftazidime/avibactam was mainly prescribed for the treatment of respiratory, urinary tract and skin and soft tissue infections caused by multidrug-resistant Gram-negative bacteria, most commonly K. pneumoniae and P. aeruginosa. The median duration of antibiotic therapy was 10 (9–22) days. A total of 94.44% of treatment courses complied with recommendations regarding indication, dosage and administration; only one case of inappropriate dose adjustment according to renal function was recorded. Conclusion: The carbapenem resistance rates of common Gram-negative bacteria, including E. coli, K. pneumoniae and P.aeruginosa, at the hospital during 2022–2024 were relatively low but showed an increasing trend over time. Ceftazidime/avibactam was used relatively appropriately in the treatment of multidrug-resistant Gram-negative infections.

CLINICAL CHARACTERISTICS AND MANAGEMENT OUTCOMES OF PLACENTA PREVIA: A STUDY AT DONG NAI GENERAL HOSPITAL IN 2025

2026-07-15T17:04:34+07:00

Background: Placenta previa is one of the leading causes of antepartum hemorrhage in the third trimester, intrapartum bleeding, and postpartum hemorrhage. It presents a major challenge for obstetricians, as pregnant women with placenta previa often require prolonged hospitalization for close monitoring, which is associated with an increased risk of blood transfusion, preterm birth, and emergency hysterectomy, ultimately leading to elevated maternal and neonatal morbidity and mortality. Objectives: This study was conducted with two primary objectives: to describe the clinical characteristics and to evaluate the management outcomes of placenta previa at Dong Nai General Hospital. Materials and methods: A descriptive cross-sectional study was conducted on 40 pregnant women admitted and delivered with a confirmed diagnosis of placenta previa at Dong Nai General Hospital between July 2025 and December 2025. Results: Maternal age under 35 years accounted for 62.5% of the study population. Regarding obstetric history, prior cesarean delivery accounted for 40.0%, uterine curettage for 5.0%, and a history of placenta previa for 2.6%. Termination of pregnancy via cesarean section was indicated in 100% of cases, comprising emergency cesarean sections (57.5%) and elective procedures (42.5%). The rate of peripartum and postpartum blood transfusion was 15.0%. No postoperative complications, such as surgical site infection or organ injury, were recorded (0.0%). The majority of newborns were in good clinical condition, with 1-minute APGAR scores greater than or equal to 7 reaching 95.0%; however, the prevalence of low birth weight (less than 2500 g) was 32.5%. Conclusion: A history of cesarean section is a common risk factor for placenta previa, and cesarean delivery remains the preferred method for pregnancy termination, predominantly performed as an emergency procedure. While no postoperative infection or organ injury was recorded, the rates of prematurity and neonatal asphyxia remain high in this study population.

PREVALENCE OF HELICOBACTER PYLORI INFECTION AND OUTCOMES OF LAPAROSCOPIC REPAIR FOR PERFORATED PEPTIC ULCERS IN ELDERLY PATIENTS IN DONG THAP

2026-05-14T09:04:02+07:00

Background: Perforated gastric and duodenal ulcers are dangerous surgical emergencies, especially in elderly patients. However, evidence regarding the effectiveness of laparoscopic repair for perforated gastric and duodenal ulcers and the prevalence of Helicobacter pylori infection at healthcare facilities located far from major centers remains limited. Objectives: To describe the clinical and paraclinical characteristics, the prevalence of Helicobacter pylori infection, the outcomes of laparoscopic repair for perforated gastric and duodenal ulcers, and the results of Helicobacter pylori eradication treatment in elderly patients in Dong Thap. Materials and methods: A prospective descriptive study was conducted on 36 patients aged ≥ 60 years with perforated gastric and duodenal ulcers who underwent laparoscopic perforation repair with intraoperative rapid urease testing at Dong Thap General Hospital from March 2025 to December 2025. Results: The mean age was 71.3 ± 8.16 years; males accounted for 69.4%, and 75% had associated comorbidities. The median onset time was 7 hours; 58.3% presented with sudden abdominal pain, and 77.8% had abdominal rigidity. The median white blood cell count was 12,245/mm³; chest/abdominal X-ray detected subdiaphragmatic free air in 86.1% of cases, while ultrasound identified free intraperitoneal air in 77.8%. Gastric perforation accounted for 77.8% of cases. The rapid urease test was positive in 58.3% of patients, and the Helicobacter pylori eradication success rate was 85.7%. Postoperative complications occurred in 27.8% of cases, and the mortality rate was 5.6%. Associated factors included advanced age, which increased postoperative complications (p = 0.032), and the Boey score, which was associated with mortality (p = 0.025). Conclusion: Laparoscopic surgery is a safe and effective treatment for perforated gastric and duodenal ulcers in elderly patients. The high rates of Helicobacter pylori infection and successful eradication support the role of bismuth-based quadruple therapy. Age, Boey score, and ASA classification are valuable factors for prognosis and clinical management.

CLINICAL AND PARACLINICAL CHARACTERISTICS AND TREATMENT OUTCOMES IN CHILDREN AGED 6-60 MONTHS WITH ACUTE ROTAVIRUS DIARRHEA RECEIVING RACECADOTRIL AT CAN THO CHILDREN’S HOSPITAL IN 2025-2026

2026-07-19T03:22:13+07:00

Background: Acute diarrhea caused by Rotavirus is a common cause of hospitalization in young children. Racecadotril has been used as supportive treatment for acute diarrhea; however, findings across studies remain inconsistent, and data from the Can Tho region are limited. Objectives: To describe the clinical and paraclinical characteristics and to compare selected treatment outcomes between children with acute Rotavirus diarrhea who received racecadotril and those who did not. Materials and methods: A prospective observational cohort study with a comparison group was conducted on 87 children aged 6–60 months with acute Rotavirus diarrhea at Can Tho Children’s Hospital from April 2025 to January 2026. Clinical, paraclinical, and treatment outcome data were collected using a standardized study form. Rotavirus infection was confirmed by a positive ROTACHECK-1 rapid test. Data were analyzed using SPSS 18.0. The Mann–Whitney U test and independent-samples t-test were used, with statistical significance set at p<0.05. Results: Among 87 children, the 12–<24-month age group accounted for the highest proportion (67.8%). Forty-five children (51.7%) received racecadotril, while 42 children (48.3%) did not. The racecadotril group had a lower number of diarrheal episodes within 48 hours than the non-racecadotril group, with medians of 8 versus 9 episodes, respectively (p=0.046); a lower total volume of intravenous fluid, 360 mL versus 500 mL (p=0.011); and a shorter hospital stay, 5.31 ± 0.23 days versus 6.61 ± ROTA 0.23 days (p<0.001). No statistically significant differences were observed between the two groups in the number of vomiting episodes within 48 hours, duration of diarrhea, or duration of vomiting. Conclusion: Acute Rotavirus diarrhea mainly occurred in children aged 12–<24 months. Children who received racecadotril had fewer diarrheal episodes within 48 hours, lower intravenous fluid requirements, and shorter hospital stays than those who did not. Racecadotril may be con-sidered a supportive treatment option for acute Rotavirus diarrhea in children.

DEVELOPMENT AND VALIDATION OF AN HPLC METHOD FOR QUANTITATIVE DETERMINATION OF MANGIFERIN IN INSTANT TEA CONTAINING DRIED MANGO LEAF EXTRACT

2026-08-03T03:51:08+07:00

Background: Instant tea containing dried mango leaf extract is a promising product for health-support applications. Mangiferin, a characteristic bioactive compound present in mango leaves, was selected as a chemical marker for product quality control and standardization. The establishment of a fully validated quantitative analytical procedure for mangiferin is therefore a scientific necessity. Objectives: To develop and validate a quantitative method for the determination of mangiferin in instant tea containing dried mango leaf extract using a Shimadzu Prominence-i LC2030C 3D Plus high-performance liquid chromatography system coupled with a photodiode array detector (PDA), in accordance with AOAC and ICH Q2(R2) guidelines. Materials and methods: simulated instant tea samples, mango leaf extract samples, placebo samples. The analytical procedure was developed on an HPLC/PDA system under optimized chromatographic conditions. Validation was conducted across five parameters: system suitability, specificity, linearity, accuracy, and precision. Results: The selected chromatographic conditions included an InertSustain C18 column (150 mm × 4.6 mm, 5 µm) with an isocratic mobile phase consisting of acetonitrile and 0.2% phosphoric acid solution (15:85, v/v), a flow rate of 1.0 mL/min, and an injection volume of 10 µL. The method met system suitability requirements and demonstrated good specificity. The linearity range was 19.90– 79.59 µg/mL with a correlation coefficient (r²) greater than 0.999. The recovery ranged from 97.30% to 99.50%, and the precision showed an RSD of 1.1%, meeting validation acceptance criteria. The mangiferin content determined in the instant tea test sample reached 99.50% of the theoretical value (RSD = 1.1%, n = 18). Conclusion: The developed method for mangiferin quantification demonstrated adequate reliability and complies with validation requirements. The method is suitable for routine quality control testing and standardization of instant tea products containing dried mango leaf extract.

CLINICAL CHARACTERISTICS AND TREATMENT OUTCOMES OF KELOIDS AND HYPERTROPHIC SCARS WITH TRIAMCINOLONE INTRALESIONAL INJECTION AT CAN THO HOSPITAL OF DERMATO-VENEREOLOGY IN 2025

2026-07-15T06:59:47+07:00

Background: Keloids and hypertrophic scars are common pathological scars resulting from abnormal wound healing. They may cause deformity of the affected area, restrict function due to tissue contracture, and adversely affect patients’ psychological well-being and quality of life. Intralesional triamcinolone injection is a widely used treatment modality. The therapeutic response to intralesional triamcinolone is believed to be influenced by certain clinical characteristics. Objectives: Clinical characteristics of keloids, hypertrophic scars of patients treated with triamcinolone intralesional injection at Can Tho Hospital of Dermato-Venereology in 2025. Materials and methods: Crosssectional descriptive study was carried out on 93 patients with keloids, hypertrophic scars at Can Tho Hospital of Dermato-Venereology from January 2025 to October 2025. Results: The median age was 28 years (8-70); 61.3% were aged 15–35 years and 54.3% were female. Keloids accounted for 61.2% and hypertrophic scars for 38.8%. Most of the scars were spontaneous (48.4%) and had a scar area of <5 cm², accounting for 61.3%. The vascular structures observed via dermoscopy in the keloid group were significantly higher than those in the hypertrophic scar group (93.0% compared to 61.1%). The mean Vancouver Scar Scale score significantly decreased from 6.48 ± 2.10 to 2.55 ± 1.81 after 24 weeks, and most of the differences between time points were statistically significant with p<0.05. Signs observed under dermoscopy tended to improve in parallel with the clinical response, especially the marked reduction in observable blood vessels, with the rate of vascular presence decreasing from 53.8% to 8.6%. Conclusion: Most of the scars were spontaneous, scar area <5 cm². The mean Vancouver Scar Scale score decreased after 24 weeks. Dermoscopy revealed that the scar features improved in parallel with the clinical response.

DIRECT MEDICAL COSTS AND WILLINGNESS TO PAY AMONG INSURED OUTPATIENTS WITH TYPE 2 DIABETES

2026-07-29T02:19:20+07:00

Background: Type 2 diabetes imposes a substantial economic burden, while real-world evidence on outpatient direct medical costs and patients’ willingness to pay (WTP) under health insurance in Vietnam remains limited. Objectives: To describe direct medical costs per outpatient visit, estimate the maximum annual WTP for a hypothetical treatment not covered by health insurance, and identify associated factors. Materials and methods: A cross-sectional study was conducted among 240 outpatients with type 2 diabetes at HCMC Hospital for Rehabilitation - Professional Diseases, from July 2025 to January 2026. Cost data were obtained from electronic medical records and billing statements; WTP was elicited through face-to-face interviews using a hypothetical valuation scenario. Results: The mean age was 61.5 ± 12.0 years, and 54.2% were women. The mean direct medical cost per outpatient visit was VND 667,329 ± 200,502, with medication accounting for the largest component. Mean WTP was VND 6.7 ± 2.2 million per year. Higher WTP was associated with age 60–74 years (β = 0.74; p = 0.012), having two comorbidities (β = 0.42; p = 0.010), and higher income (β = 0.35; p < 0.001). Conclusion: Medication costs constituted the largest component of direct medical costs per outpatient visit. WTP was associated with age, comorbidity burden, and income. The reported WTP reflects patients’ stated ability and preference to pay under a hypothetical scenario and should not be interpreted as a societal cost-effectiveness threshold.

EVALUATION OF SHORT-TERM TREATMENT OUTCOMES AFTER OPEN REDUCTION AND INTERNAL FIXATION FOR CLOSED ACETABULAR FRACTURES

2026-07-05T10:41:17+07:00

Background: Acetabular fractures are complex intra-articular injuries of the hip, typically resulting from high-energy trauma and frequently associated with polytrauma and potentially lifethreatening conditions. Early reduction and open reduction and internal fixation (ORIF) aim to restore acetabular anatomy and hip congruency, thereby improving functional outcomes. Objectives: To describe clinical and radiographic characteristics of closed acetabular fractures and to evaluate shortterm outcomes after surgical treatment. Materials and methods: A prospective longitudinal study of 36 patients who underwent surgery at Can Tho Central General Hospital from June 2024 to March 2026. Results: The mean age was 46 ± 17.2 years. Traffic accidents were the most common mechanism of injury (69.4%); the remaining cases resulted from falls from height and domestic accidents. Hip dislocation occurred in 55.6% of cases. The most common fracture patterns were posterior wall fractures (41.7%), posterior column with posterior wall fractures (27.8%), and anterior column fractures (22.2%). Surgery was performed within 14 days after injury in 86.1% of patients. Mean operative time was 149 ± 40 minutes. According to Matta criteria, reduction was good in 80.5%, fair in 16.7%, and poor in 2.8%. At the 3-month follow-up, hip function assessed by the Merle d’Aubigné score was excellent–good in 77.8% and fair in 22.2%. Recorded complications included superficial infection (2.8%) and 3 cases of sciatic nerve injury. Conclusion: ORIF for closed acetabular fractures resulted in favorable short-term radiographic and functional outcomes. However, longer-term followup is required to evaluate sustained functional recovery and late complications.

CORRELATION BETWEEN SERUM VITAMIN B12 LEVELS AND DISEASE SEVERITY IN WOMEN WITH MELASMA AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

2026-07-29T03:41:29+07:00

Background: Melasma is a common benign hyperpigmentation disorder that significantly impacts aesthetics and quality of life, particularly in women. Certain micronutrients, including vitamin B12, are suggested to be associated with its pathogenesis and clinical severity. Objectives: To determine serum vitamin B12 levels and evaluate the correlation between vitamin B12 concentration and disease severity in women with melasma at Can Tho University of Medicine and Pharmacy Hospital. Materials and methods: A comparative analytical study was conducted from July 2025 to March 2026 on 60 subjects, consisting of 30 patients with melasma and 30 healthy controls. Serum vitamin B12 concentrations were quantified and analyzed for their correlation with melasma severity using the Melasma Area and Severity Index (MASI). Results: Serum vitamin B12 levels in the melasma group were lower than those in the control group (579.87 ± 182.09 pg/mL versus 694.80 ± 243.89 pg/mL, p = 0.043). A strong negative correlation was observed between serum vitamin B12 concentration and MASI scores (Spearman’s rs = -0.712; p < 0.001). Conclusion: Serum vitamin B12 levels are lower in women with melasma compared to healthy individuals and exhibit a significant inverse correlation with disease severity as measured by the MASI score. Further studies are required to confirm this association.

ASSESSMENT OF HEPATIC STEATOSIS BY ULTRASOUND-GUIDED ATTENUATION PARAMETER AND ATORVASTATIN TREATMENT OUTCOMES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2026-07-19T08:45:47+07:00

Background: Metabolic dysfunction-associated steatotic liver disease is common in patients with type 2 diabetes mellitus. Objectives: To assess hepatic steatosis using the ultrasoundguided attenuation parameter, related factors, and changes after three months of treatment. Materials and methods: This study at Van Hanh General Hospital from April 2025 to March 2026 included 93 patients in the baseline analysis and 70 patients in a single-arm before-and-after intervention using atorvastatin 20 mg/day plus lifestyle counseling. Results: Disease prevalence was 91.4%. After three months, the ultrasound-guided attenuation parameter decreased from 0.733 to 0.692 dB/cm/MHz and low-density lipoprotein cholesterol from 4.00 to 2.61 mmol/L; 54.3% improved by at least one steatosis grade. Conclusion: The ultrasound-guided attenuation parameter is useful for assessment and short-term monitoring.

CLINICAL AND PARACLINICAL CHARACTERISTICS OF BACTERIAL CO-INFECTION PNEUMONIA IN PATIENTS WITH PULMONARY TUBERCULOSIS BY TREATMENT STAGES AT CAN THO LUNG HOSPITAL

2026-08-06T08:59:06+07:00

Background: Bacterial pneumonia co-infection in patients undergoing pulmonary tuberculosis treatment is a major clinical challenge in diagnosis and treatment. Objectives: To describe and compare selected clinical, paraclinical, and bacteriological characteristics of bacterial co-infection pneumonia in patients with pulmonary tuberculosis according to treatment phase. Materials and methods: An analytical cross-sectional descriptive study was conducted on 125 patients with pulmonary tuberculosis under treatment who had bacterial co-infection pneumonia at Can Tho Lung Hospital from July 2024 to May 2026. Results: Among patients with bacterial co-infection pneumonia during pulmonary tuberculosis treatment, those in the intensive phase accounted for the majority, at 63.2%. Male patients accounted for 66.4%, and the mean age was 59.8 ± 17.5 years. Common symptoms included dyspnea (79.2%), chest pain (68.8%), fever (54.4%), and purulent sputum production (48.8%). Patients in the continuation phase had higher rates of hemoptysis, dyspnea, chest pain, fever, high-risk PSI classification, elevated CRP, and pleural effusion than those in the intensive phase. Streptococcus pneumoniae was the most common pathogen, accounting for 45.6%; Gram-negative bacteria accounted for 54.4%, mainly Klebsiella pneumoniae and Enterobacter cloacae. MDR accounted for 80.8%, XDR for 16.0%, and PDR for 3.2%. Conclusion: In the study sample, bacterial co-infection pneumonia among patients undergoing treatment for pulmonary tuberculosis was more common during the intensive phase. Patients in the continuation phase had higher rates of hemoptysis, dyspnea, chest pain, fever, high-risk PSI classification, elevated CRP, and pleural effusion than those in the intensive phase. The microbiological spectrum was diverse and the rate of antimicrobial resistance was high. Therefore, early sputum culture and antimicrobial susceptibility testing are necessary to guide appropriate antibiotic therapy.

RESEARCH ON THE rs501120 POLYMORPHISM IN THE CXCL12 GENE AND SOME FACTORS ASSOCIATED WITH CORONARY ARTERY LESIONS IN PATIENTS WITH CHRONIC CORONARY SYNDROME AT SEVERAL HOSPITALS IN CAN THO, 2024-2026

2026-08-06T08:14:43+07:00

Background: Coronary artery disease is the leading cause of death worldwide. In addition to traditional risk factors, genetic factors play a significant role in the mechanisms of atherosclerosis and coronary artery disease. The rs501120 polymorphism of the CXCL12 gene is considered to be associated with coronary artery damage. Objectives: To investigate the characteristics of the rs501120 polymorphism of the CXCL12 gene and to evaluate factors associated with the severity of coronary artery lesions in patients with chronic coronary syndrome. Materials and methods: A cross-sectional descriptive study was conducted on 84 patients diagnosed with chronic coronary syndrome who underwent coronary angiography at Can Tho Central General Hospital and Can Tho University of Medicine and Pharmacy Hospital between 2024 and 2026. Results: The genotype frequencies for the rs501120 polymorphism in the significant stenosis group were CC: 7.1%, CT: 23.8%, and TT: 69%; the TT genotype was identified as an independent factor associated with coronary artery lesions based on the Gensini score with p = 0.043. Smoking (p = 0.001), hypertension (p = 0.029), obesity (p = 0.019), and a family history of premature cardiovascular disease (p < 0.001) were statistically significantly associated with significant coronary artery stenosis. Conclusion: The TT genotype of the rs501120 polymorphism is independently associated with coronary artery lesions as assessed by the Gensini score.

A STUDY ON THE PREVALENCE OF VAGINITIS CAUSED BY CANDIDA SPP. AMONG WOMEN ATTENDING GYNECOLOGICAL CLINICS AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL, 2024-2025

2026-05-20T08:40:36+07:00

Background: Vaginitis caused by Candida spp. is one of the most common gynecological conditions in women. It typically presents with itching, burning sensation, and abnormal vaginal discharge, significantly affecting quality of life, with a high risk of recurrence and chronicity. If not diagnosed and treated promptly, the condition may lead to pelvic inflammatory disease, infertility, and adverse pregnancy outcomes, thereby posing a substantial burden on reproductive health. Objectives: 1. To determine the prevalence and clinical characteristics of Candida spp. associated vaginitis; 2. To describe associated factors among women attending gynecological examination at Can Tho University of Medicine and Pharmacy Hospital in 2024-2025. Materials and methods: A cross-sectional descriptive study was conducted among women attending gynecological clinics at the Can Tho University of Medicine and Pharmacy Hospital from June 2024 to June 2025. Participants were interviewed using a structured questionnaire, underwent gynecological examination, and had direct microscopic examination of vaginal discharge (wet mount). Results: Among 119 women included in the study, the prevalence of vulvovaginal candidiasis was 40.3%. The most common clinical symptoms were pruritus (68.8%), burning sensation (16.7%), dysuria (14.6%), dyspareunia (10.4%), vaginal mucosal erythema and edema (31.3%), vulvar erythema and edema (18.8%), cervicitis (8.3%), and thick, white, curd-like discharge (47.9%). Notably, 4.2% of cases were asymptomatic. Associated factors included the use of vaginal cleansing solutions 4-7 times per week (62.5%), improper perineal hygiene after urination (68.9%), wearing tight underwear (66.7%), changing sanitary pads <3 times per day during menstruation (35.4%), and working in humid environments (14.6%). Conclusion: The prevalence of vaginitis caused by Candida spp. among women was 40.3%. Further studies on treatment and community-based preventive measures are recommended.

CLINICAL AND PARACLINICAL CHARACTERISTICS AND CLASSIFICATION OF MAXILLOFACIAL INFECTIONS ORIGINATING FROM MANDIBULAR MOLARS

2026-08-04T03:17:28+07:00

Background: Maxillofacial infections originating from mandibular molars often progress rapidly and may spread extensively. Describing the clinical and paraclinical characteristics is essential for appropriate management. Objectives: To describe the clinical and paraclinical characteristics and to classify the severity of maxillofacial infections caused by mandibular molars. Materials and methods: An analytical cross-sectional study was conducted on 30 hospitalized patients diagnosed with maxillofacial infections secondary to mandibular molars from June 2025 to January 2026 at Tay Nguyen Regional General Hospital, Dak Lak. Variables included clinical features, hematological findings, microbiological results, imaging characteristics, and classification of infection severity. Results: A total of 30 patients were included, with a mean age of 50.6 ± 17.4 years, males and females were equally represented. Facial asymmetry was observed in 93.3% of cases and trismus in 46.7%, with no significant sex differences in clinical symptoms (p > 0.05). Females had a longer duration of symptoms than males (11.7 ± 5.3 vs. 8.9 ± 4.6 days, p = 0.048). The mean white blood cell count was 14.5 ± 5.1 G/L, with leukocytosis present in 86.7% of patients. Although the mean white blood cell count was higher in males than in females (15.8 ± 5.0 vs. 13.2 ± 4.9 G/L), the difference was not statistically significant (p = 0.167). Ultrasound findings most commonly showed abscess formation (53.3%), with no significant sex differences in imaging characteristics. Infection classification revealed that diffuse cellulitis accounted for 53.3% of cases, deep localized infection for 40.0%, and superficial localized infection for 6.7%. The proportion of diffuse infection was higher in males than in females (60.0% vs. 46.7%), but this difference was not statistically significant (p = 0.447). Conclusion: Maxillofacial infections caused by mandibular molars were predominantly diffuse and frequently associated with leukocytosis. No statistically significant sex-related differences were observed in infection severity or paraclinical characteristics, except for a longer duration of symptoms in females.

PREVALENCE OF SARCOPENIA AND ASSOCIATED FACTORS IN NON-DIALYSIS CHRONIC KIDNEY DISEASE PATIENTS

2026-08-03T08:21:10+07:00

Background: Sarcopenia is a prevalent complication among non-dialysis chronic kidney disease patients, tending to deteriorate with disease progression, thereby increasing mortality risk and impairing quality of life. Objectives: To determine the prevalence and factors associated with sarcopenia in non-dialysis chronic kidney disease patients. Materials and methods: A crosssectional descriptive study was conducted on 84 patients with chronic kidney disease not yet on regular dialysis at Can Tho University of Medicine and Pharmacy Hospital during the period 2024– 2026. Characteristics related to sarcopenia and chronic kidney disease were analyzed to determine the prevalence of sarcopenia and factors associated with sarcopenia in chronic kidney disease patients. Data were processed using SPSS Statistics 27, with p < 0.05 considered statistically significant. Results: The prevalence of sarcopenia was 35.7%, of which 9.5% had severe sarcopenia. The prevalence of sarcopenia across CKD stages 3a, 3b, 4, and 5 was 28.6%, 44.4%, 66.7%, and 75.0%, respectively (p < 0.001). CKD stage, BMI, and sex were independent factors associated with sarcopenia. Conclusion: The prevalence of sarcopenia was 35.7%. CKD stage, BMI, and sex were independently associated with sarcopenia after adjustment. Screening for sarcopenia should be performed in CKD patients, particularly in those with advanced stages.

RESEARCH ON THE STATUS OF HUMAN RESOURCES AND INFLUENCING FACTORS AT LONG AN GENERAL HOSPITAL IN 2025-2026

2026-08-04T05:14:14+07:00

Background: Human resources for health (HRH) is a critical determinant for success in the provision of healthcare services. As a frontline provincial hospital, Long An General Hospital faces numerous challenges in sustaining and developing its workforce to meet growing demands for medical care. Objectives: To describe the status of human resources and to analyze factors affecting the retention and development of human resources at Long An General Hospital in the 2025-2026 period. Materials and methods: A cross-sectional descriptive study using a mixed-methods approach. The quantitative component surveyed 384 staff members (selected from a total of 834 personnel) using a self-administered questionnaire, combined with secondary personnel data; the qualitative component included in-depth interviews with 12 managers and 03 focus group discussions. Results: The study recorded a staff-to-bed ratio of 0.89 staff/bed. The proportion of doctors in the professional workforce reached 17.9%, and the proportion of doctors with postgraduate degrees reached 42.3%. The survey findings and qualitative analysis identified key issues related to compensation policies, workload, the working environment, and training opportunities. Conclusion: The study provides useful initial information on the status and influencing factors of human resources at the hospital. The hospital should focus on improving compensation policies, fostering a positive working environment and developing appropriate recruitment and training plans in line with Ministry of Health regulations.

IMAGING CHARACTERISTICS AND DIAGNOSTIC VALUE OF MAGNETIC RESONANCE IMAGING IN CEREBRAL ARTERIOVENOUS MALFORMATIONS

2026-08-05T08:32:17+07:00

Background: Cerebral arteriovenous malformations are characterised by direct shunts between the arterial and venous systems through a nidus without an intervening capillary network, and may cause intracranial haemorrhage with high rates of neurological sequelae and mortality. Magnetic resonance imaging allows detection and characterisation of the nidus. Objectives: To describe the imaging characteristics and evaluate the diagnostic value of magnetic resonance imaging in cerebral arteriovenous malformations. Materials and methods: A prospective crosssectional descriptive study of 43 patients with suspected cerebral arteriovenous malformation who underwent non-contrast brain magnetic resonance imaging and digital subtraction angiography at Can Tho Central General Hospital and Can Tho Stroke International Services from June 2024 to January 2026. Results: Digital subtraction angiography confirmed cerebral arteriovenous malformation in 37 of 43 patients, of which magnetic resonance imaging detected 36. Among the 36 niduses detected on magnetic resonance imaging: supratentorial location accounted for 88.9% and eloquent-area involvement for 38.9%; nidus size < 3 cm accounted for 52.8%; exclusively superficial venous drainage accounted for 75.0%; and Spetzler-Martin grade I was the most frequent, at 38.9%. In the diagnosis of cerebral arteriovenous malformation, magnetic resonance imaging achieved a sensitivity, specificity and accuracy of 97.3%, 100% and 97.7%, respectively; accuracy in identifying draining veins and feeding arteries were 86.1% and 83.3%, respectively. Conclusion: Magnetic resonance imaging demonstrates high diagnostic value for cerebral arteriovenous malformations.

EVALUATION OF SERUM INTERLEUKIN-6 LEVEL IN SUPPORTING THE DIAGNOSIS OF SPONTANEOUS BACTERIAL PERITONITIS IN PATIENTS WITH DECOMPENSATED CIRRHOSIS

2026-07-29T02:27:03+07:00

Background: Decompensated cirrhosis is commonly complicated by spontaneous bacterial peritonitis (SBP), which increases the risk of multi-organ failure and mortality. The diagnosis of SBP currently relies primarily on an absolute ascitic fluid polymorphonuclear neutrophil count of ≥250 cells/mm³, which is considered the definitive diagnostic criterion. However, early identification of inflammatory activity in ascitic fluid remains clinically challenging, particularly in patients with atypical clinical manifestations. Serum Interleukin-6 (IL-6) is a pro-inflammatory cytokine involved in systemic inflammatory responses and may be elevated in the setting of infection. Therefore, serum IL-6 may serve as a biomarker to support the diagnosis of SBP in patients with decompensated cirrhosis. Objectives: 1) To describe serum IL-6 level in patients with decompensated cirrhosis; 2) To evaluate the predictive value of serum IL-6 for spontaneous bacterial peritonitis. Materials and methods: A crosssectional descriptive study was conducted in 35 patients diagnosed with decompensated cirrhosis at the Department of General Internal Medicine, Tay Ninh General Hospital, from 5/2025 to 2/2026. Results: The prevalence of spontaneous bacterial peritonitis (SBP) was 37.1%. The male-to-female ratio was approximately equal. The mean age of the patients was 53.9 ± 13.1 years. The median serumIL-6 level was significantly higher in the SBP group compared with the non-SBP group (181 pg/mL vs. 48.4 pg/mL; p = 0.007). SerumIL-6 concentration showed a fairly good predictive value for SBP, with an AUC of 0.78 (95% CI: 0.61–0.94). At the cut-off value of 69.4 pg/mL, IL-6 had a sensitivity of 84.6%, specificity of 68.2%, positive predictive value of 61.1%, and negative predictive value of 88.2%. Conclusion: Serum IL-6 had a fairly good supportive diagnostic value for SBP in patients with decompensated cirrhosis.

SERUM TNF-α LEVELS AND THEIR VALUE IN PREDICTING DISEASE SEVERITY IN PATIENTS WITH ACUTE PANCREATITIS AT CAN THO CENTRAL GENERAL HOSPITAL, 2025-2026

2026-08-07T07:51:08+07:00

Background: TNF-α participates in the early inflammatory response in acute pancreatitis; data on its predictive value and combined models in Can Tho remain limited. Objectives: To describe serum TNF-α and selected clinical and laboratory characteristics; develop severity prediction models combining TNF-α with APACHE II or BISAP; and assess treatment outcomes and the association with in-hospital mortality. Materials and methods: This prospective analytical observational study included 96 patients with acute pancreatitis at Can Tho Central General Hospital during 2025-2026. Serum TNF-α was measured by ELISA within 24 hours. Two logistic models combined TNF-α with APACHE II or BISAP; discrimination was assessed using ROC curves and AUCs. Results: Severe acute pancreatitis occurred in 31.2%. TNF-α was higher in severe than non-severe disease (8.59 [4.24-11.98] vs. 5.07 [4.01-6.29] pg/mL; p < 0.001). TNF-α alone had an AUC of 0.722. The TNF-α + APACHE II model had an AUC of 0.971 versus 0.961 for APACHE II alone; the TNF-α + BISAP model had an AUC of 0.907 versus 0.820 for BISAP alone. In-hospital mortality was 9.4%. TNF-α was higher among non-survivors than survivors (20.40 [10.63-25.22] vs. 5.19 [3.98-6.84] pg/mL; p < 0.001); the univariable OR was 1.269 per 1 pg/mL increase (95% CI: 1.113-1.447). Conclusion: Serum TNF-α was elevated in severe acute pancreatitis. The combined models had descriptively higher AUCs than their corresponding individual scores in this cohort, but direct statistical testing of AUC differences was not performed. Mortality findings are exploratory; external validation is required.

CLINICAL CHARACTERISTICS, SKIN PH, SKIN HYDRATION, AND ASSOCIATED FACTORS IN PATIENTS WITH SEBORRHEIC DERMATITIS AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

2026-08-05T09:36:33+07:00

Background: Seborrheic dermatitis is a chronic inflammatory skin disorder associated with sebaceous gland activity, affecting both children and adults. Objectives: To investigate clinical characteristics, skin pH, skin hydration, and associated factors in adult patients with seborrheic dermatitis treated at Can Tho University of Medicine and Pharmacy Hospital. Materials and methods: A cross-sectional descriptive study was conducted on 65 patients diagnosed with seborrheic dermatitis. Data on clinical features, skin pH values, and skin hydration levels were collected. Results: The disease was most common in the 18–29 age group (73.8%), with a male predominance (76.9%). Most patients lived in urban areas (83.1%) and were students (69.2%). Lesions were mainly localized (53.8%), well-demarcated (58.5%), and of moderate severity (72.3%). Oily skin was predominant (76.9%), and 87.7% of patients reported stress-related factors. Regarding skin physiological parameters, most patients had increased skin pH (>6.0) in 72.3% and decreased skin hydration (level 1) in 67.7%. No statistically significant associations were found between demographic and lifestyle factors and disease severity, skin pH, or skin hydration (p >0.05). However, males tended to have more severe disease, and patients experiencing stress showed a tendency toward lower skin hydration levels. Conclusion: Elevated pH and reduced hydration were associated with impaired skin barrier function and may promote microbial proliferation on the skin. No statistically significant associations were observed between demographic and lifestyle factors and disease severity, skin pH, or skin hydration.

SURGICAL OUTCOMES OF TREATMENT FOR MANDIBULAR SYMPHYSIS FRACTURES USING MINIPLATE FIXATION

2026-08-12T03:45:49+07:00

Background: Mandibular fractures of the symphyseal region are common injuries in maxillofacial trauma. Although miniplate fixation has demonstrated several advantages, further evaluation of its clinical effectiveness in real-world settings is warranted. Objectives: To evaluate the outcomes of surgical treatment for mandibular symphysis fractures using miniplate osteosynthesis. Materials and methods: Uncontrolled clinical interventional study was conducted on 35 patients with mandibular symphysis fractures treated by open reduction and internal fixation using miniplates at Vinh Long General Hospital from May 2025 to January 2026. Results: Most patients were younger than 30 years old (80.0%), with males accounting for 77.1%. Traffic accidents were the leading cause of injury (80.0%). The majority of patients had a preoperative period of 3–7 days (91.4%), and the mean operative time was 30.1 ± 6.6 minutes. Regarding fracture characteristics, most fractures occurred at the symphysis region (91.4%), involved a single fracture line (94.2%), and showed no displacement (85.7%). After 3 months of follow-up, most patients achieved good overall outcomes (94.2%). Conclusion: Open reduction and internal fixation of mandibular symphysis fractures using miniplates is a safe and effective treatment method, particularly in simple fracture cases.

PREDICTIVE VALUE OF THE CHAMPS AND ROCKALL SCORES FOR REBLEEDING IN PATIENTS WITH PEPTIC ULCER BLEEDING

2026-05-12T03:16:30+07:00

Background: Rebleeding is a serious complication that increases the need for repeat intervention, prolongs hospital stay, and adversely affects clinical outcomes in patients with upper gastrointestinal bleeding due to peptic ulcer disease. Prognostic scoring systems such as ROCKALL and CHAMPS are commonly used to support risk stratification and guide monitoring and treatment strategies. Objectives: To compare the predictive value of the CHAMPS and ROCKALL scores for rebleeding in patients with peptic ulcer bleeding. Materials and methods: An analytical crosssectional study was conducted on 95 patients with upper gastrointestinal bleeding due to peptic ulcer disease treated at Tay Ninh General Hospital from July 2025 to February 2026. Results: The median age of patients was 58.00 (49.00–67.00) years, and males accounted for 74.7%. During hospitalization, rebleeding occurred in 5 patients (5.3%). Both ROCKALL and CHAMPS scores were higher in patients with rebleeding than in those without rebleeding. ROC analysis showed a higher observed AUC for CHAMPS than for ROCKALL (0.813 vs 0.681). A CHAMPS score ≥4 yielded a sensitivity of 60.0%, specificity of 100%, and NPV of 97.8%, whereas a ROCKALL score ≥7 showed a sensitivity of 60.0% and specificity of 90.0%. Conclusion: In this single-center study, the observed AUC for CHAMPS was higher than that for ROCKALL for predicting rebleeding. However, with only five rebleeding events, these findings should be considered preliminary and hypothesis-generating and are insufficient to establish superiority or to support replacing ROCKALL in clinical practice. Prospective multicenter validation with a substantially larger number of events is required.